Association of<i>Helicobacter pylori</i>Gastric Infection with the Suppressed Thomsen-Friedenreich Antigen Natural Humoral Response

Kurtenkov, Oleg; Wadström, Torkel; Klaamas, Kersti; Vorobjova, Tamara; Uibo, Raivo

doi:10.3109/00365529509093248

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…This has also been considered for natural ABO(H)-blood-group isohemagglutinins (Wiener, 1951). We have shown (Kurtenkov et al, 1995) that the low TFA antibody level is associated with Helicobacter pylori gastric infection, considered to be an important factor in gastric carcinogenesis (Parsonnet, 1993). H. pylon infection is linked to the Lewis-blood-group phenotype (Boren et al, 1993), which is often altered in patients with gastric cancer (Torrado et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

The lower level of natural anti‐thomsen‐friedenreich antigen (TFA) agglutinins in sera of patients with gastric cancer related to ABO(H) blood‐group phenotype

Kurtenkov¹,

Klaamas²,

Miljukhina³

1995

Intl Journal of Cancer

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The TFA is a tumor-associated, blood-group-related glycosidic precursor structure [Gal(beta 1-3)GalNAc]. Its expression in carcinomas is accompanied by a decrease of natural TFA antibodies in serum. The relationship between the ABO(H)-blood-group phenotype and natural anti-TFA immune response in patients with gastric cancer was studied. The level of TFA agglutinins in the sera of patients with gastric cancer and of healthy controls was examined by the hemagglutination of neuraminidase-treated blood-group-O donor erythrocytes. Individuals were classified as weak or strong TFA responders. They were also classified by ABO(H)-blood-group status, age, cancer stage, tumor morphology and level of isohemagglutinins. The proportion of weak TFA responders (WR) in cancer patients was 33, 50, 50 and 20% (for O, A, B and AB blood groups respectively), as compared with 11.7, 14.5, 13.9 and 26.1% for blood-group-related controls. The difference between cancer patients and controls was significant for all blood groups except group AB. Further analysis showed age-dependence in blood-group-O and -B controls, with a high level of WR in the older group. Blood-group-A cancer patients had the greatest and uniform suppression of the level of TFA agglutinins, irrespective of age, cancer stage or tumor morphology, and lower levels of anti-B isohemagglutinins.

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Section: Discussionmentioning

confidence: 99%

The lower level of natural anti‐thomsen‐friedenreich antigen (TFA) agglutinins in sera of patients with gastric cancer related to ABO(H) blood‐group phenotype

Kurtenkov¹,

Klaamas²,

Miljukhina³

1995

Intl Journal of Cancer

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IgG immune response toHelicobacter pylori antigens in patients with gastric cancer as defined by ELISA and immunoblotting

Klaamas¹,

Held

Wadström

et al. 1996

Int. J. Cancer

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Helicobocter pylori infection is considered to be a risk factor for gastric cancer. A high prevalence of H. pylori infection and high gastric-cancer incidence are characteristic of the Estonian population. To evaluate the relationship between these 2 events, we studied the seroprevalence of H. pylori in gastric cancer patients (n = 182) and in healthy blood donors (n = 306).A relative anti-H. pylori IgG antibody activity, as detected by ELSA and immunoblot patterns, was correlated with age, stage of the disease arid tumor morphology. A significantly higher H. pylori seroprevalence was found in patients in the early stages of tumor development compared with both advanced cancer patients and controls. No significant difference in H. pylori seroprevalence between patients with the intestinal and diffuse types of tumor growth was observed. A decline in the recognition of putatively cross-reacting (33-66 kDa) antigens was noted in the cancer group. The response to vacuolating toxinrelated 85-kDa and CagA 120-kDa protein antigens was not altered and was observed more often in the younger group of cancer patients.

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Association ofHelicobacter pyloriGastric Infection with the Suppressed Thomsen-Friedenreich Antigen Natural Humoral Response

Abstract: The data suggest that the TFA natural immune response, which is known to participate in tumor-host relationships, is also involved in H. pylori-host interactions, probably as a natural factor of resistance against H. pylori infection.

Cited by 2 publications

References 23 publications

The lower level of natural anti‐thomsen‐friedenreich antigen (TFA) agglutinins in sera of patients with gastric cancer related to ABO(H) blood‐group phenotype

The lower level of natural anti‐thomsen‐friedenreich antigen (TFA) agglutinins in sera of patients with gastric cancer related to ABO(H) blood‐group phenotype

IgG immune response toHelicobacter pylori antigens in patients with gastric cancer as defined by ELISA and immunoblotting

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