2008
DOI: 10.1002/ijc.23539
|View full text |Cite
|
Sign up to set email alerts
|

Association of Helicobacter pylori infection with chronic atrophic gastritis: Meta‐analyses according to type of disease definition

Abstract: Helicobacter pylori is a major risk factor for chronic atrophic gastritis (CAG). A large variety of definitions of CAG have been used in epidemiologic studies in the past. The aim of this work was to systematically review and summarize estimates of the association between H. pylori infection and CAG according to the various definitions of CAG. Articles on the association between H. pylori infection and CAG published until July 2007 were identified. Separate meta‐analyses were carried out for studies defining C… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

5
37
0
2

Year Published

2009
2009
2022
2022

Publication Types

Select...
7
2

Relationship

3
6

Authors

Journals

citations
Cited by 56 publications
(44 citation statements)
references
References 99 publications
5
37
0
2
Order By: Relevance
“…The much higher incidence rates of CAG that were observed in H. pylori positive individuals compared to H. pylori negative individuals and the according rate ratios observed in the meta-analysis are consistent with findings from a number of cross-sectional studies which disclosed a strong association between H. pylori infection and CAG [5]. Similarly, the H. pylori specific virulence factor cagA has consistently been shown to be associated with an increased risk of CAG in cross-sectional studies.…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…The much higher incidence rates of CAG that were observed in H. pylori positive individuals compared to H. pylori negative individuals and the according rate ratios observed in the meta-analysis are consistent with findings from a number of cross-sectional studies which disclosed a strong association between H. pylori infection and CAG [5]. Similarly, the H. pylori specific virulence factor cagA has consistently been shown to be associated with an increased risk of CAG in cross-sectional studies.…”
Section: Discussionsupporting
confidence: 88%
“…However, the majority of epidemiological studies on CAG and its risk factors have been cross-sectional [4]. Infection with the gastric bacterium Helicobacter pylori was shown to be strongly associated with CAG in a recently published meta-analysis that relied on cross-sectional data [5]. However, to prove the causal role of H. pylori infection and other risk factors in the development of CAG, analysis of follow-up data is necessary.…”
Section: Introductionmentioning
confidence: 99%
“…The remaining 9,684 participants were characterized with respect to sociodemographic characteristics, lifestyle factors, family and own medical history, H. pylori infection, and CAG. The presence of CAG cases was determined by the following serology-based definition which has been commonly used in previous studies (21): pepsinogen I <70 ng/mL and pepsinogen I/II <3.…”
Section: Discussionmentioning
confidence: 99%
“…Since H. pylori eradication decreases the incidence of gastroduodenal ulcer and prevents its recurrence, CAG and gastric cancer have become the focus of great interest in terms of the feasibility of disease reversal or chemoprevention following eradication of the bacterium. A metaanalysis of studies on the association between H. pylori infection and CAG that were published until July 2007 was carried out by Weck and Brenner [7], with separate meta-analyses of studies defining CAG based on gastroscopy with biopsy, serum pepsinogen I (PG I) only, the PG I/pepsinogen II (PG II) ratio only, or a combination of the PG I and PG I/PG II ratios. The number of analyzed studies (n) and the summary odds ratios (ORs) (95% confidence intervals) were as follows: gastroscopy with biopsy: n=34, OR=6.4 (4.0-10.1); PG I only: n=13, OR=0.9 (0.7-1.2); PG I/PG II ratio: n=8, OR=7.2 (3.1-16.8); combination of PG I and PG I/PG II: n=20, OR=5.7 (4.4-7.5).…”
Section: Fig 1 Gastric Diseases Associated With Helicobacter Pylorimentioning
confidence: 99%