Association of<i>Helicobacter pylori</i>infection with systemic inflammation in preeclampsia

Üstün, Yusuf; Üstün, Yaprak Engin; Ozkaplan, Esra; Otlu, Barış; Tekerekoğlu, Mehmet Sait

doi:10.3109/14767050903121456

Cited by 36 publications

(4 citation statements)

References 23 publications

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“…This epidemiologic association has subsequently been confirmed by several studies ( 11 , 13 ) (Table 1 ), and a correlation between persistent and virulent infections (VacA/CagA seropositive patients) for HP and PE complicated by fetal intrauterine growth restriction (IUGR) has also been shown ( 13 ).…”

Section: Epidemiologic Association Between Helicobacter Pylmentioning

confidence: 63%

Insights into the Role of Helicobacter pylori Infection in Preeclampsia: From the Bench to the Bedside

et al. 2014

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Preeclampsia (PE) is defined as a hypertensive and coagulative disorder affecting about 2–8% of all pregnancies and is one of the main causes of maternal and fetal morbidity and mortality. Despite the great amount of studies run in this field, little is known about the precise pathogenic mechanisms behind PE. While endothelial and trophoblast dysfunctions, exaggerated inflammatory response, and hypercoagulative state have been shown to play a key role in the occurrence of PE, the primary trigger is still unknown. One of the hypotheses is that some infectious agents may represent a trigger for PE onset. Consistently, higher seroprevalence of Helicobacter pylori (HP) infection, a Gram-negative bacterium with a specific tropism for human gastric mucosa, has been shown in women with PE. Even tighter association has been found between PE and infection with cytotoxin-associated gene-A (CagA)-positive strains of HP. Recent in vitro studies have shown that anti-CagA antibodies cross-react with human trophoblast cells and determine a functional impairment in terms of cell invasiveness, thus, providing the first pathogenic model of HP infection-mediated placental damage. Since in the early process of implantation and placental development, trophoblast invasion of maternal decidua is a crucial step, the proposed autoimmune mechanism induced by HP infection, negatively interfering with the fetal side of the early developing placenta, may represent a mechanism explaining the higher seropositivity for HP infection among PE women. However, the contribution of HP infection to the pathogenesis of PE or to the worsening of its clinical presentation need to be further investigated as well as the possible impact of pre-pregnancy screening and eradication of HP infection on the incidence of the syndrome.

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Section: Epidemiologic Association Between Helicobacter Pylmentioning

confidence: 63%

Insights into the Role of Helicobacter pylori Infection in Preeclampsia: From the Bench to the Bedside

et al. 2014

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“…For instance, the link between preeclampsia and periodontitis has been widely reported [137,138], as well as acute infections such as urinary tract infections [139]. Chronic maternal infections, such as cytomegalovirus [140], Chlamydia pneumoniae [141], and Helicobacter pylori [142,143], have also been demonstrated to play a role in preeclampsia.…”

Section: Preeclampsiamentioning

confidence: 99%

Maternal HPV Infection: Effects on Pregnancy Outcome

Condrat

Filip

Gherghe

et al. 2021

Viruses

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The human papilloma virus (HPV) infection, caused by a ubiquitous virus typically transmitted through the direct contact of infected organs, either through the skin or mucosa, is the most common sexually transmitted infection, placing young women at a high risk of contracting it. Although the vast majority of cases spontaneously clear within 1–2 years, persistent HPV infection remains a serious concern, as it has repeatedly been linked to the development of multiple malignancies, including cervical, anogenital, and oropharyngeal cancers. Additionally, more recent data suggest a harmful effect of HPV infection on pregnancy. As the maternal hormonal environment and immune system undergo significant changes during pregnancy, the persistence of HPV is arguably favored. Various studies have reported an increased risk of adverse pregnancy outcomes among HPV-positive women, with the clinical impact encompassing a range of conditions, including preterm birth, miscarriage, pregnancy-induced hypertensive disorders (PIHD), intrauterine growth restriction (IUGR), low birth weight, the premature rupture of membranes (PROM), and fetal death. Therefore, understanding the mechanisms employed by HPV that negatively impact pregnancy and assessing potential approaches to counteract them would be of interest in the quest to optimize pregnancy outcomes and improve child survival and health.

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“…Nowadays it is well established that the exposure to biological agents, e.g., Chlamydia pneumoniae, Helicobacter pylori, Cytomegalovirus, Human Immunodeficiency Virus, can be associated with PE, due to the consequent inflammatory response and the enhancement of uteroplacental acute atherosis [41][42][43][44]. However, although subjects experiencing occupational biological risks are normally provided with specific training on adequate job procedures, and on the employment of personal protective equipment to avoid/reduce the probability of exposure, to understand the relationship between such risk factors and the HDP onset remains a critical maternal health issue.…”

Section: Biological Risk Factorsmentioning

confidence: 99%

Occupational Risk Factors and Hypertensive Disorders in Pregnancy: A Systematic Review

Spadarella

Leso

Fontana

et al. 2021

IJERPH

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Hypertensive disorders in pregnancy (HDP), including gestational hypertension (GH) and preeclampsia (PE), characterize a major cause of maternal and prenatal morbidity and mortality. In this systematic review, we tested the hypothesis that occupational factors would impact the risk for HDP in pregnant workers. MEDLINE, Scopus, and Web of Knowledge databases were searched for studies published between database inception and 1 April 2021. All observational studies enrolling > 10 pregnant workers and published in English were included. Un-experimental, non-occupational human studies were excluded. Evidence was synthesized according to the risk for HDP development in employed women, eventually exposed to chemical, physical, biological and organizational risk factors. The evidence quality was assessed through the Newcastle–Ottawa scale. Out of 745 records identified, 27 were eligible. No definite conclusions could be extrapolated for the majority of the examined risk factors, while more homogenous data supported positive associations between job-strain and HDP risk. Limitations due to the lack of suitable characterizations of workplace exposure (i.e., doses, length, co-exposures) and possible interplay with personal issues should be deeply addressed. This may be helpful to better assess occupational risks for pregnant women and plan adequate measures of control to protect their health and that of their children.

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Association ofHelicobacter pyloriinfection with systemic inflammation in preeclampsia

Abstract: We demonstrated high levels of serum CRP and TNF-alpha in preeclamptic women who were seropositive to Helicobacter pylori in comparison with those in seronegative subjects.

Cited by 36 publications

References 23 publications

Insights into the Role of Helicobacter pylori Infection in Preeclampsia: From the Bench to the Bedside

Insights into the Role of Helicobacter pylori Infection in Preeclampsia: From the Bench to the Bedside

Maternal HPV Infection: Effects on Pregnancy Outcome

Occupational Risk Factors and Hypertensive Disorders in Pregnancy: A Systematic Review

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