Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type

Abstract

Polymorphisms in the HOX transcript antisense intergenic RNA (HOTAIR) have been recently associated with susceptibility to different cancers. Here, a meta-analysis was performed to derive a more precise estimation of the involvement of HOTAIR polymorphisms in cancer development. Data from cases (n = 7,772) and controls (n = 9,075) were extracted from eligible studies (n = 10) identified in a comprehensive literature search conducted in PubMed, Embase, and the Web of Science databases through January 20, 2016. Overall, association between polymorphism rs920778 and increased cancer risk was significant in allele contrast (odds ratio (OR) = 1.239, 95% confidence interval (CI) = 1.032 - 1.487) and recessive models (OR = 1.614, 95% CI = 1.082 - 2.406). In subgroup analysis based on ethnicity, a significant association between polymorphism rs920778 and cancer susceptibility was observed in Asians under all models, but was most compelling under recessive (OR = 2.128, 95% CI = 1.417 - 3.197) and homozygous models (OR = 2.764, 95% CI = 2.221 - 3.440). Subgroup analysis by cancer type revealed a significant association between polymorphism rs4759314 and susceptibility to gastric cancer in allele contrast (OR = 1.262, 95% CI = 1.073 - 1.486), dominant (OR = 1.280, 95% CI = 1.060 - 1.547), and heterozygous models (OR = 1.288, 95% CI = 1.057 - 1.570). In conclusion, the results indicated that HOTAIR polymorphism rs920778 was more generally associated with cancer risk, particularly in Asians, while rs4759314 was a risk factor for gastric cancer.

Quantitative assessment of lncRNA HOTAIR polymorphisms and cancer risk in Chinese population: a meta-analysis based on 26,810 subjects

“…However, the results remain contradictory and inconclusive, especially in different geographical location and ethnicity groups. In 2016, three similar meta-analyses involving eight articles explored the association of HOTAIR polymorphisms with several kinds of cancers among worldwide population [ 34 – 36 ]. However, none of them drew a conclusion for Chinese population.…”

HOTAIR lncRNA SNPs rs920778 and rs1899663 are associated with smoking, male gender, and squamous cell carcinoma in a Chinese lung cancer population

“…Genetic polymorphism rs4759314 from the AA genotype to the GG genotype is significantly associated with susceptibility to gastric cancer [19]. The TT genotype at the rs1899663 site increases the risk of breast cancer compared with the GG homozygotes in the Chinese population [20]. Therefore, these four sites are closely associated with the onset, progression, and poor prognosis of various cancers [21][22][23][24].…”

Influence of HOTAIR rs920778 and rs12826786 Genetic Variants on Prostate Cancer Risk and Progression-Free Survival

“…These observations are likely to reflect tumor-specific carcinogenic processes that are not shared among these tumor types, and also due to ethnic differences among studies. In fact, a recent meta-analysis showed that HOTAIR SNP rs920778 was associated with gastric cancer and esophageal squamous cell carcinoma, but not with breast cancer, in Asians but not in Caucasians [38]. Nonetheless, limitations in the sample size of our and others' studies must not be ruled out, warranting further studies in larger cohorts to validate these findings.…”