Association ofMatrix Metalloproteinase-1Promoter Polymorphisms With Asthma Risk

Abstract

Background/Aim: Matrix metalloproteinase-1 (MMP-1) expression has been documented as an influential contributor to the intricate milieu of allergic airway inflammation, tissue remodeling, and the exacerbation of asthma's severity. However, the genetic role underlying MMP-1 in the context of asthma has remained enigmatic, with its full implications yet to be unveiled. Considering this, our research was designed to investigate the association of MMP-1 -1607 rs1799750 and the propensity for asthma severity. Patients and Methods: As a case-control investigation, our study enrolled 198 individuals diagnosed with asthma and age-and sex-matched 453 non-asthmatic controls. The genotypes of MMP-1 rs1799750 were determined utilizing the polymerase chain reactionrestriction fragment length polymorphism methodology. Results: The frequency distributions of 2G/2G, 1G/2G and 1G/1G genotypes at MMP-1 rs1799750 were 49, 42.9, and 8.1%, respectively, among the patients with asthma. This pattern was not different from that of controls (43.7, 46.8, and 9.5%, respectively) (p for trend=0.4486). The allelic frequency pertaining to the variant 1G allele within the asthma group was 29.5%, with a non-significant disparity compared to the 32.9% in the control group (p=0.2596). Noticeably, there was a positive association between MMP-1 rs1799750 2G/1G and 1G/1G genotypes with asthma severity (p=0.0060). Conclusion: Our research indicated that the presence of MMP-1 rs1799750 1G allele might not be the sole arbiter of an individual's susceptibility to asthma, yet its potential to function as a discerning prognostic marker for the severity of asthma emerged as a noteworthy finding deserving attention and further exploration.Asthma, an extensively prevalent chronic obstructive ailment characterized by intricate airway remodeling, commands global attention due to its substantial impact. The global burden of asthma is staggering, affecting approximately 300 million individuals worldwide, with its prevalence exhibiting an ongoing escalation (1, 2). At its core, asthma manifests with persistent airway inflammation, bronchial hyperresponsiveness (BHR), and variable airway obstruction. The hallmark of clinical presentation lies in the structural modifications occurring within the airways, collectively 365

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