Association of <i>MTHFR</i> C677T gene polymorphism with metabolic syndrome in a Chinese population: a case–control study

Wang, Jin; Xu, Lijuan; Xia, Hongmiao; Liu, Ying; Tang, Shiqi

doi:10.1177/0300060518768969

Cited by 18 publications

(18 citation statements)

References 34 publications

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“…The association between the CC genotype of MTHFR and WHR in the present study could be explained by an unequal distribution of overweight and obese subjects or the size sample; however, we did not observe significant differences in frequencies of the MTHFR genotypes between the subjects with normal and excessive body weight, which is in line with other studies. 32,35 Furthermore, because of contradictory results of other studies 35,36 concerning a relationship between MTHFR genotypes and anthropometric measurements, further analysis are still necessary to clarify the role of the MTHFR rs1801133 polymorphism in overweight and obesity.…”

Section: Discussionmentioning

confidence: 99%

Associations of plasma betaine, plasma choline, choline intake, and MTHFR polymorphism (rs1801133) with anthropometric parameters of healthy adults are sex‐dependent

Młodzik-Czyżewska

Malinowska

Szwengiel

et al. 2022

J Human Nutrition Diet

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Background Choline and its metabolites apppear to have relationships with body mass index (BMI), body fat, and body weight, but the research results have proved inconsistent. We thus investigated the associations of plasma levels of trimethylamine N‐oxide (TMAO), choline, and betaine with anthropometric measurements, including modulatory effects of genetics and diet. Methods The study was performed on a group of 421 adults, aged 20–40 years, who had been recruited in Poland. Plasma concentrations of choline, betaine, and TMAO were determined using reverse‐phase ultra‐high‐performance liquid chromatography electrospray ionisation mass spectrometry. The following polymorphisms were genotyped using TaqMan probes: rs180113 (MTHFR), rs70991108 (DHFR), rs2236225 (MTHFD1), and rs7946 and rs12325817 (PEMT). We employed multivariate linear regression to examine the associations between anthropometric measurements, one‐carbon metabolism metabolites, and genotypes. Results Higher plasma choline was associated with higher BMI (β = 0.17; p < 0.01), body weight (β = 0.11; p < 0.05), body fat mass (FM) (β = 0.10; p < 0.05), and waist circumference (WC) (β = 0.14; p < 0.01), whereas higher choline intake was associated with lower body FM (β = −0.14; p < 0.01) and lower WC (β = −0.12; p < 0.01). After stratification by sex, plasma betaine was found to be associated with lower BMI (β = −0.20; p < 0.05) and body weight (β = −0.16; p < 0.05) in men only, whereas choline intake was associated with lower body FM (β = −0.19; p < 0.05) and waist‐to‐hip ratio (WHR) (β = −0.19; p < 0.05) and MTHFR CC genotype was associated with WHR (β = 0.15; p < 0.05) in women only. Conclusions Higher plasma betaine and higher dietary choline are associated with lower FM and body weight, whereas higher plasma choline is positively associated with body weight status and adiposity. Moreover, these associations appear to be sex‐specific.

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Section: Discussionmentioning

confidence: 99%

Associations of plasma betaine, plasma choline, choline intake, and MTHFR polymorphism (rs1801133) with anthropometric parameters of healthy adults are sex‐dependent

Młodzik-Czyżewska

Malinowska

Szwengiel

et al. 2022

J Human Nutrition Diet

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“…To our knowledge, the finding that carrier females of the MTHFR 677T allele have a minor risk of elevated waist circumference has not been reported in healthy people, but Wang et al analyzed this parameter between patients with metabolic syndrome from China and they found a trend towards a protector effect against elevated waist circumference in the patients with the TT genotype [OR=0.60 (0.27–1.32); p=0.204] (31), which is in accordance with our observations. On the other hand, the analysis of means of anthropometric measurements showed that waist circumference was increased in individuals with TT genotype.…”

Section: Discussionmentioning

confidence: 99%

Association of the MTHFR 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico

Leal-Ugarte

Peralta-Leal

Meza-Espinoza

et al. 2019

Journal of Medical Biochemistry

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Summary Background Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship of the MTHFR 677C>T polymorphism with obesity and biochemical variables in young individuals of Mexico. Methods A total of 316 young individuals were included in the study, 172 with normal weight (NW) and 144 with over weight/obesity. Body mass index (BMI) was classified as NW, overweight, and obesity. Also, waist circumference was measured. Moreover, glucose, total cholesterol, and triglycerides were determined. Genotyping for MTHFR 677C>T polymorphism was performed by the PCR-RFLP method. Results There was no difference in the distribution of the MTHFR 677C>T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW. However, an analysis stratified by gender showed a significant protector effect of the TT genotype against obesity in males and elevated waist circumference in females. Also, overweight/obese individuals with TT genotype had less risk of high cholesterol or triglycerides than overweight/obese subjects with the other genotypes. Conclusions These results suggest that the MTHFR 677T polymorphism might not be a risk factor for being overweight/obesity. Rather, on the basis of our results, this variant could be a protector effect. However, further large-scale population-based studies are still necessary to clarify the role of the MTHFR 677C>T polymorphism in overweight, obesity, and lipid profile level.

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“…34 It has been proposed that the dyslipidaemia caused by the MTHFR C667T gene polymorphism is one of the major factors in the progression of ischaemic stroke. 35 A previous study demonstrated that the MTHFR C677T polymorphism, in conjunction with traditional risk factors such as LDL-C, HDL-C and smoking, was a risk factor for atherosclerosis. 36 The C667T polymorphism in the MTHFR gene influences carotid atherosclerosis pathogenesis by destroying endothelial cells and promoting smooth muscle cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…34 It has been proposed that the dyslipidaemia caused by the MTHFR C667T gene polymorphism is one of the major factors in the progression of ischaemic stroke. 35…”

Section: Discussionmentioning

confidence: 99%

Association of the methylenetetrahydrofolate reductase (MTHFR) gene variant C677T with serum homocysteine levels and the severity of ischaemic stroke: a case–control study in the southwest of China

Huang

et al. 2022

J Int Med Res

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Objective To determine whether the methylenetetrahydrofolate reductase ( MTHFR) C677T gene polymorphism is linked to the risk of ischaemic stroke and circulating homocysteine (Hcy) levels in a Chinese population. Methods This case–control study recruited angiogram-diagnosed patients with ischaemic stroke and healthy control subjects. The plasma Hcy concentrations were measured and the MTHFR C677T gene polymorphism was genotyped. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity of the ischaemic stroke. Results This study recruited 198 patients with ischaemic stroke and 168 controls. The TT genotype conferred a higher risk for ischaemic stroke than the CC genotype (odds ratio of 3.563; 95% confidence interval [CI] 1.412, 4.350). The T allele was the predisposing allele for ischaemic stroke. Hcy had an area under the receiver operating characteristic (ROC) curve of 0.624 (95% CI 0.530, 0.758). The ROC for Hcy demonstrated its usefulness in predicting ischaemic stroke. Hcy levels were not associated with ischaemic stroke severity as measured by the NIHSS. Conclusion The MTHFR C677T gene polymorphism affects circulating Hcy levels. The MTHFR C677T gene polymorphism and hyperhomocysteinaemia may play important roles in predicting the risk of ischaemic stroke.

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Association of MTHFR C677T gene polymorphism with metabolic syndrome in a Chinese population: a case–control study

Cited by 18 publications

References 34 publications

Associations of plasma betaine, plasma choline, choline intake, and MTHFR polymorphism (rs1801133) with anthropometric parameters of healthy adults are sex‐dependent

Associations of plasma betaine, plasma choline, choline intake, and MTHFR polymorphism (rs1801133) with anthropometric parameters of healthy adults are sex‐dependent

Association of the MTHFR 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico

Association of the methylenetetrahydrofolate reductase (MTHFR) gene variant C677T with serum homocysteine levels and the severity of ischaemic stroke: a case–control study in the southwest of China

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