Association of<i>NFKBIA</i>polymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations

Gao, Jingfang; Pfeifer, Daniella; He, Lili; Qiao, Fang; Zhang, Zhiyong; Arbman, Gunnar; Wang, Zhenlei; Jia, Cun-Rong; Carstensen, John; Sun, Xiaoying

doi:10.1080/00365520600880856

Cited by 47 publications

(35 citation statements)

References 14 publications

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“…The Chinese (Gao et al 2007) and Australian Jewish (Curran et al 2002) populations were the most distinct with respect to the NF-jBIA 3 0 UTR polymorphism. The frequency of the A allele was considerably lower than in other populations, and it is slightly different among the other populations, including the Turkish population studied here (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Identification of NF-κB1 and NF-κBIΑ Polymorphisms Using PCR–RFLP Assay in a Turkish Population

2009

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A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was used in a Turkish population to determine the frequency of polymorphisms of the nuclear factor-kappa (NF-kappaB1) and NF-kappaBIA genes, which have been shown to be related to several inflammatory diseases and cancer pathogenesis. Total genomic DNA was isolated from peripheral blood samples taken from 565 healthy volunteers living in Aydin Province. The genomic regions in question were amplified by PCR, and the polymorphisms in these regions were detected by a PCR-RFLP assay. The frequencies were 10.3% for the NF-kappaB1 -94ins/delATTG del/del genotype, 49.1% for del/ins, and 40.6% for ins/ins. The genotype frequencies of the NF-kappaBIA 3'UTR A --> G genotypes were A/A 19.2%, A/G 42.3%, and G/G 38.5%. Distribution of genotype frequencies was tested by Hardy-Weinberg; the NF-kappaB1 gene was in Hardy-Weinberg equilibrium (chi(2) = 3.402, P > 0.05), the NF-kappaBIA gene was not (chi(2) = 8.293, P < 0.05).

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Section: Discussionmentioning

confidence: 99%

Identification of NF-κB1 and NF-κBIΑ Polymorphisms Using PCR–RFLP Assay in a Turkish Population

2009

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“…Certain variant of NF-κBIα such as NF-κBIα with AG genotype may be associated with an increased risk of developing colorectal cancer. [26] How NF-κB interacts with other proteins to regulate gene expressions in carcinogenesis is an important aspect of cancer research.…”

Section: Introductionmentioning

confidence: 99%

Oncogene Functions of FHL2 Are Independent from NF-κBIα in Gastrointestinal Cancer

Qiao

Wang

Pang

et al. 2008

Pathol. Oncol. Res.

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Four and a half of LIM-only protein 2 (FHL2) is an adaptor protein that can interact with many transcription factors and thus plays a variety of biological functions. Previous studies by our group have demonstrated that suppression of FHL2 was capable of inducing tumor cell differentiation, and inhibiting the growth of experimental gastric and colon cancers. Therefore, FHL2 appears to function as an oncogene. In order to further explore the mechanisms of how FHL2 is involved in tumorigenesis, we attempted to test whether FHL2 has any direct association with nuclear factor (NF-kappaB), the most important transcription factor involved in apoptosis, inflammation, and carcinogenesis. Using an Yeast Two Hybrid (Y2H) screening system, we have shown that FHL2 may have an interaction with NF-kappaBIalpha, the coding gene for IkappaBalpha which is the most potent endogenous inhibitor for NF-kappaB activation. However, subsequent studies using co-immunoprecipitation and co-localization failed to confirm the Y2H finding. Down-regulation of FHL2 by FHL2-siRNA down-regulated the expression of NF-kappaB p65. We therefore concluded that under the physiological condition, FHL2 may activate NF-kappaB pathway, even though such an activation may not be mediated by a direct binding of FHL2 to NF-kappaB inhibitor protein IkappaB.

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“…The risk decreased gradually with the carriage of one or two risk alleles, since 33.3% of the 75 patients with AG genotype and 18.5% of the 27 patients with the AA genotype had extensive disease compared to 55.3% of those with the GG genotype, despite all patients having a similar age at onset and a similar disease duration (GG 10.9 years, GA 11.3 years, AA 8.9 years). This may be of potential interest, since in a recent study from Sweden, the GG genotype was associated with poorer survival (hazard ratio 3.10) of sporadic colorectal cancer patients, independent of gender, age, tumor location, Dukes' stage, and differentiation [37]. Furthermore, carriage of the NFKB1-94delATTG allele significantly increased the risk (OR 3.81-7.73) for unselected and sporadic colorectal cancer in Swedish patients [38].…”

Section: Discussionmentioning

confidence: 88%

The 3′UTR NFKBIA Variant Is Associated with Extensive Colitis in Hungarian IBD Patients

et al. 2008

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Association ofNFKBIApolymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations

Abstract: Chinese individuals >or=50 years of age carrying the AG genotype of NFKBIA may be at an increased risk of developing CRC, and the GG genotype of NFKBIA may be considered as a prognostic factor for Swedish CRC patients.

Cited by 47 publications

References 14 publications

Identification of NF-κB1 and NF-κBIΑ Polymorphisms Using PCR–RFLP Assay in a Turkish Population

Identification of NF-κB1 and NF-κBIΑ Polymorphisms Using PCR–RFLP Assay in a Turkish Population

Oncogene Functions of FHL2 Are Independent from NF-κBIα in Gastrointestinal Cancer

The 3′UTR NFKBIA Variant Is Associated with Extensive Colitis in Hungarian IBD Patients

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