Association of <i>PBEF</i> gene polymorphisms with acute lung injury, sepsis, and pneumonia in a northeastern Chinese population

Liu, Yaxin; Shao, Yong; Yu, Bu Chin; Sun, Liyan; Lv, Fuzhen

doi:10.1515/cclm-2012-0238

Cited by 8 publications

(7 citation statements)

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“…Among them, visfatin is an adipocytokine with insulin-like activity [8], and elevated plasma visfatin has been reported in patients with metabolic syndrome, especially in obese and T2DM patients [9][10][11][12]. Greater visfatin expression has been also found in cardiovascular diseases [13], inflammatory disorder [14] and a prognosis of cancer [15]. The circulating visfatin level is strongly related to T2DM and is found to be positively associated with IR [12,16]; it increases with progressive b-cell deterioration [11].…”

Section: Introductionmentioning

confidence: 99%

High-visfatin levels in women with polycystic ovary syndrome: evidence from a meta-analysis

Sun¹,

Wei³

et al. 2015

Gynecological Endocrinology

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Section: Introductionmentioning

confidence: 99%

High-visfatin levels in women with polycystic ovary syndrome: evidence from a meta-analysis

Sun¹,

Wei³

et al. 2015

Gynecological Endocrinology

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“…Another case–control study found that the IL-6 -572 polymorphism was associated with ALI [22]. Several studies have suggested that pre-B-cell colonyenhancing factor (PBEF) gene polymorphisms were associated with susceptibility and prognosis of ALI [23,24]. The plasminogen activator inhibitor-1 (PAI-1) 4G allele was associated with worse outcome in ALI/ARDS [25].…”

Section: Discussionmentioning

confidence: 99%

“…First, a sepsis without ALI group was used for comparison to exclude the possibility of a false association with sepsis. Second, to minimize racial admixture, we focused on central Han Chinese patients, which could be regarded as one single homogenous population [23,24]. Third, to reduce the heterogeneous etiologies for ALI, the present study only included patients whose primary etiology for ALI was sepsis.…”

Section: Discussionmentioning

confidence: 99%

Haplotype analysis of ApoAI gene and sepsis-associated acute lung injury

Hao

2014

Lipids Health Dis

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BackgroundApolipoprotein A1 (ApoA1) is the major apoprotein constituent of high density lipoprotein (HDL) which exerts innate protective effects in systemic inflammation. However, its role in the acute lung injury (ALI) has not been well studied. In the present study we investigated the association between polymorphisms of ApoA1 gene and ALI in a Chinese population.MethodsThree polymorphisms of the ApoA1 gene (rs11216153, rs2070665, and rs632153) were genotyped by TaqMan method in 290 patients with sepsis-associated ALI, 285 patients sepsis alone and 330 age- and sex-matched healthy controls.ResultsWe found rs11216153 polymorphism of ApoA1 was associated with ALI, the GG genotype and G allele was common in the ALI patients (76.9%, 88.1%, respectively) than both in the control subjects (55.8%, 75.8%, respectively) and in the sepsis alone patients (58.2%, 78.4%, respectively). Haplotype consisting of these three SNPs strengthened the association with ALI susceptibility. The frequency of haplotype GTG in the ALI samples was significantly higher than that in the healthy control group (OR = 2.261, 95% CI: 1.735 ~ 2.946, P <0.001) and the sepsis alone group (OR = 1.789, 95% CI: 1.373 ~ 2.331.P < 0.001). Carriers of the haplotype TTG had a lower risk for ALI compared with healthy control group (OR = 0.422, 95% CI: 0.310 ~ 0.574, P < 0.001) and sepsis alone group (OR = 0.491, 95% CI: 0.356 ~ 0.676, P <0.001).ConclusionsThese results indicated that genetic variants in the ApoA1 gene might be associated with susceptibility to sepsis-associated ALI in Han Chinese population.

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“…The −1001G variant allele was associated with increased susceptibility to acute lung injury and ARDS in African American and Caucasian populations. The −1001G variant was also associated with a higher ICU mortality rate in septic patients in a Caucasian population [6], [13]–[15]. Despite the previous identification of several available biomarkers, their available data are inconsistent and clinical relevance has not yet been established.…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Single Nucleotide Polymorphisms Associated with Acute Respiratory Distress Syndrome by Exome-Seq

et al. 2014

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Acute respiratory distress syndrome (ARDS) is a lung condition characterized by impaired gas exchange with systemic release of inflammatory mediators, causing pulmonary inflammation, vascular leak and hypoxemia. Existing biomarkers have limited effectiveness as diagnostic and therapeutic targets. To identify disease-associating variants in ARDS patients, whole-exome sequencing was performed on 96 ARDS patients, detecting 1,382,399 SNPs. By comparing these exome data to those of the 1000 Genomes Project, we identified a number of single nucleotide polymorphisms (SNP) which are potentially associated with ARDS. 50,190SNPs were found in all case subgroups and controls, of which89 SNPs were associated with susceptibility. We validated three SNPs (rs78142040, rs9605146 and rs3848719) in additional ARDS patients to substantiate their associations with susceptibility, severity and outcome of ARDS. rs78142040 (C>T) occurs within a histone mark (intron 6) of the Arylsulfatase D gene. rs9605146 (G>A) causes a deleterious coding change (proline to leucine) in the XK, Kell blood group complex subunit-related family, member 3 gene. rs3848719 (G>A) is a synonymous SNP in the Zinc-Finger/Leucine-Zipper Co-Transducer NIF1 gene. rs78142040, rs9605146, and rs3848719 are associated significantly with susceptibility to ARDS. rs3848719 is associated with APACHE II score quartile. rs78142040 is associated with 60-day mortality in the overall ARDS patient population. Exome-seq is a powerful tool to identify potential new biomarkers for ARDS. We selectively validated three SNPs which have not been previously associated with ARDS and represent potential new genetic biomarkers for ARDS. Additional validation in larger patient populations and further exploration of underlying molecular mechanisms are warranted.

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Association of PBEF gene polymorphisms with acute lung injury, sepsis, and pneumonia in a northeastern Chinese population

Abstract: This study suggested that -1543T allele might be a protective factor for ALI and sepsis, but it apparently had no connection with pneumonia in northeastern Chinese Han patients.

Cited by 8 publications

References 0 publications

High-visfatin levels in women with polycystic ovary syndrome: evidence from a meta-analysis

High-visfatin levels in women with polycystic ovary syndrome: evidence from a meta-analysis

Haplotype analysis of ApoAI gene and sepsis-associated acute lung injury

Identification of Novel Single Nucleotide Polymorphisms Associated with Acute Respiratory Distress Syndrome by Exome-Seq

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