Association of <i>SDF1β</i> (G801A) and <i>GNB3</i> (C825T) polymorphisms with the incidence and severity of coronary artery disease

Eba, Ale; Raza, ST; Abbas, Mohammad; Rizvi, Saliha; Rajput, Muneshwar; Mahdi, Farzana

doi:10.1080/09674845.2018.1527802

Cited by 4 publications

(6 citation statements)

References 13 publications

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“…We performed meta-analysis from the five newest different studies analyzing SDF-1 3'A gene polymorphism in diverse ethnic background, Iranian, Chinese, Indian, and Italian population. The pooled OR from these five case-control studies suggested that the presence of SDF-1 3'A gene polymorphism as a genetic risk factor for CAD [14], [15], [16], [17], [18]. The present finding was in contrast to a former meta-analysis by Wu et al which elaborated association between rs1801157/SDF-1 gene polymorphism and CHD [19].…”

Section: Discussioncontrasting

confidence: 99%

“…The study results yielded five studies to be analyzed (Table 1) which can be included in the study [14], [15], [16], [17], [18]. All five articles were observational case-control studies.…”

Section: Resultsmentioning

confidence: 99%

“…Although all studies defined CAD cases based on coronary angiography findings, in three studies patients was diagnosed with MI and later confirmed by the invasive study to have CAD, whereas in studies by Eba et al and Zhang et al, there was no clear explanation about the occurrent of MI in CAD groups [14], [18]. At the end, all those subjects shared a common underlying pathogenic process, atherosclerosis, and the SDF-1 gene polymorphism, therefore strongly correlated with CAD [14], [15], [16], [18]. SDF-1 is a chemokine that regulating neutrophil migration to the atherosclerosis lesion [22], [23].…”

Section: Discussionmentioning

confidence: 97%

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The Stromal Cell-derived Factor-1/CXCL12 3’A-gene Polymorphism is Related to the Increased Risk of Coronary Artery Disease: A Systematic Review and Meta-analysis

Prabawa

Lestari

Muliarta

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Single-nucleotide polymorphism in the stromal cell-derived factor-1 (SDF-1)/CXCL12 gene had been associated with an increased risk of coronary artery disease (CAD). However, several published studies have shown inconsistent results. AIM: A meta-analysis was assessed to evaluate the association between SDF-1 3’A-gene polymorphism and CAD in the literature. METHODS: A systematic review was conducted in accordance with PRISMA guidelines and adhering to the Cochrane Handbook for Systematic Reviews. The literature search strategy was carried out on April 3, 2019, from PubMed, EBSCO, Google Scholar, and DOAJ during 2013–2018 period using various keywords related to SDF-1, CXCL12, polymorphism, and CAD. Original data from the group, case-control study, English full-text, and DNA polymorphism assessment using polymerase chain reaction were enrolled. Gene polymorphism in A-base nucleotide among patients with CAD and healthy subjects were evaluated. All data were analyzed using Review Manager 5.3 (Cochrane, Denmark) for meta-analysis. RESULTS: Five eligible studies extracted for data analysis (2013–2018) based on the assessment of 2-independent reviewers. Several studies have been excluded due to irrelevant criteria evaluated. A significant result was found between SDF-1 3’A gene polymorphism with the increased risk of CAD in the overall effect evaluation using a fixed-effects model (odds ratio [OR]: 2.02; 95% confidence interval 1.54-2.65; I2: 34%; p<0.001) on the forest plot. CONCLUSION: Our meta-analysis suggests that gene polymorphism in A-base nucleotide of SDF-1/CXCL-12 was associated with the susceptibility of CAD. However, a bigger-scale and well-design of case-control study should be conducted to clarify these conclusions.

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Section: Discussioncontrasting

confidence: 99%

“…The study results yielded five studies to be analyzed (Table 1) which can be included in the study [14], [15], [16], [17], [18]. All five articles were observational case-control studies.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

The Stromal Cell-derived Factor-1/CXCL12 3’A-gene Polymorphism is Related to the Increased Risk of Coronary Artery Disease: A Systematic Review and Meta-analysis

Prabawa

Lestari

Muliarta

et al. 2020

Open Access Maced J Med Sci

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“…Beyond the role of GNB3 pathogenic variants in the etiology of CSNB1H, [8] Siffert and colleagues [78], described the c.825C>T (rs5443) polymorphism in exon 10 of the gene as linked to the expression of a shortened splice variant, Gβ 3 s, whose translated protein is characterized by the deletion of 41 amino acids, responsible of enhanced G-proteins signal transduction [78]. The c.825C>T polymorphism is associated with an increased risk of hypertension [78][79][80][81], obesity [59,82], diabetes [83], metabolic syndrome component [84,85], depression [86,87], seasonal variations in mood and behaviors [88], functional dyspepsia [89,90], stroke [91,92], arrhythmia [93], coronary artery disease [94,95], and other cardiovascular phenotypes [96][97][98][99]. In addition, duplication and overexpression of GNB3 gene is responsible for a syndromic form of childhood obesity [59,100].…”

Section: G Protein Subunit Beta 3 (Gnb3 Gβ 3 )mentioning

confidence: 99%

The Emerging Role of Gβ Subunits in Human Genetic Diseases

Malerba

Nittis

Merla

2019

Cells

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Environmental stimuli are perceived and transduced inside the cell through the activation of signaling pathways. One common type of cell signaling transduction network is initiated by G-proteins. G-proteins are activated by G-protein-coupled receptors (GPCRs) and transmit signals from hormones, neurotransmitters, and other signaling factors, thus controlling a number of biological processes that include synaptic transmission, visual photoreception, hormone and growth factors release, regulation of cell contraction and migration, as well as cell growth and differentiation. G-proteins mainly act as heterotrimeric complexes, composed of alpha, beta, and gamma subunits. In the last few years, whole exome sequencing and biochemical studies have shown causality of disease-causing variants in genes encoding G-proteins and human genetic diseases. This review focuses on the G-protein β subunits and their emerging role in the etiology of genetically inherited rare diseases in humans.

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“…The present communication aims to continue this process with a summary of those papers published during 2019 that report the practical advances in biomedical science, classified by mostly discipline and technique. One that falls between disciplines in that of Eba and colleagues, who found differences in the frequencies of single nucleotide polymorphisms (SNPs) in SDF-1β (coding for stromal cell derived growth factor, also known as chemokine CXCL-12) and in GNB3 (coding for a component of an intracellular second messenger pathway) in 155 patients with coronary artery disease compared to 185 healthy controls, although neither SNPs were linked to the severity of the disease as defined by number of atherosclerotic arteries [1].…”

Section: Introductionmentioning

confidence: 99%

British Journal of Biomedical Science in 2019. What have we learned?

Blann

2019

British Journal of Biomedical Science

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In 2019 the British Journal of Biomedical Science published 40 articles in the various disciplines that comprise biomedical science. These were one review, 22 original articles and 17 'In Brief' short reports. Of those citing original data, the majority were in cellular pathology (14 papers), clinical chemistry (9 papers), and microbiology (6 papers: 4 in bacteriology and 2 in virology). There were 3 papers in haematology and 2 in andrology, whilst 5 papers crossed traditional discipline boundaries (such as the molecular genetics of IL6, liver function tests, and hepatocellular carcinoma). Over two-thirds of papers used techniques in molecular genetics. The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists.

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Association of SDF1β (G801A) and GNB3 (C825T) polymorphisms with the incidence and severity of coronary artery disease

Cited by 4 publications

References 13 publications

The Stromal Cell-derived Factor-1/CXCL12 3’A-gene Polymorphism is Related to the Increased Risk of Coronary Artery Disease: A Systematic Review and Meta-analysis

The Stromal Cell-derived Factor-1/CXCL12 3’A-gene Polymorphism is Related to the Increased Risk of Coronary Artery Disease: A Systematic Review and Meta-analysis

The Emerging Role of Gβ Subunits in Human Genetic Diseases

British Journal of Biomedical Science in 2019. What have we learned?

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