Association of ICAM-1 K469E polymorphism with neurocysticercosis

Singh, Amrita; Singh, Satyendra Kumar; Paliwal, Vimal Kumar; Gupta, Rakesh K.; Prasad, Kashi Nath

doi:10.1016/j.jneuroim.2014.07.018

Cited by 18 publications

(8 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent studies have shown that TLR-4 and ICAM-1 gene polymorphisms are found to be associated with symptomatic NCC [26,27]. Additionally, MMP-9 polymorphism was associated with symptoms in NCC patients having calcified cysts [28].…”

Section: Peripheral Immune Response and Cytokinesmentioning

confidence: 99%

Immunopathogenesis of Neurocysticercosis: Role of Cytokines

Singh¹

2015

Immunome Res

View full text Add to dashboard Cite

Neurocysticercosis (NCC) is caused by the larva of Taenia solium, when it is lodged in the central nervous system (CNS). NCC is identified as the major cause of community acquired epilepsy, especially in the developing countries. It is also increasingly being reported in the developed world due to human migration from the disease endemic countries. However, some individuals with similar NCC lesions may remain asymptomatic and the reason for this asymptomatic status largely remains unknown. However, studies from our center suggest that cytokines play important role in disease pathogenesis. In the present review, we have discussed the role of different cytokines in the pathogenesis of NCC in human.

show abstract

Section: Peripheral Immune Response and Cytokinesmentioning

confidence: 99%

Immunopathogenesis of Neurocysticercosis: Role of Cytokines

Singh¹

2015

Immunome Res

View full text Add to dashboard Cite

show abstract

“…[ 16 ] ICAM-1 K469E polymorphism has been reported that it might be associated with susceptibility to many diseases, such as ischemic stroke (IS), Crohn's disease (CD), coronary heart disease (CHD), and neurocysticercosis (NCC). [ 17 – 20 ] The multidrug resistance (MDR) and expression of P-glycoprotein are the causes of chemotherapy failure. By understanding the mechanism of these causes, they may have clinical significance in overcoming disease caused by drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Correlations of ICAM-1 gene polymorphisms with susceptibility and multidrug resistance in colorectal cancer in a Chinese population

Liu

Xin

2017

Medicine

View full text Add to dashboard Cite

Background:Colorectal cancer (CRC) is a malignant gastrointestinal tumor with a high mortality rate, including both colon and rectal cancer. In order to provide clinical guidance for the treatment of CRC, this study is conducted to investigate the correlations of intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms with susceptibility and multidrug resistance (MDR) of colorectal cancer (CRC).Methods:A total of 195 patients with CRC were selected as the observation group and 188 healthy people enrolled as the control group. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was used to test ICAM-1 A13848G and K469E polymorphisms. The expressions of MDR-associated protein topoisomerase II (Topo II) and P-glycoprotein (P-gp) in CRC tissues were detected by immunohistochemistry. The analysis on association of clinical indexes of CRC patients with ICAM-1 gene polymorphisms was performed.Results:The frequencies of KK genotype and K allele of K469E in the observation group were significantly higher than that in the control group. KE + EE genotype and E allele might be protective factors for CRC. The distribution of genotypes, K469E KK and KE+EE, was highly correlated with histologic grade of tumor differentiation. Compared with adjacent normal tissues, positive rates of Topo II and P-gp expression were significantly increased in CRC tissues. Topo II expression in CRC patients was positively associated with lymph node metastasis and depth of tumor invasion, whereas P-gp expression was only associated with depth of tumor invasion. Higher positive rates of Topo II and P-gp expression were observed in ICAM-1 K469E KK genotype carriers, indicating that ICAM-1 K469E KK genotype might be related to MDR in CRC.Conclusion:These findings in the current study suggested that ICAM-1 K469E polymorphism is highly correlated with susceptibility and MDR in CRC.

show abstract

“…No estudo de Singh (2014) observou-se um maior nível de circulação de ICAM-1 em pacientes com neurocisticercose sintomáticos do que o de indivíduos assintomáticos e controles saudáveis. A diferença entre casos assintomáticos e controle foi pouca e notou-se que houve um aumento de ICAM-1 mesmo em pacientes considerados saudáveis.…”

Section: Discussionunclassified

Análise Da Concentração De Sicam-1 Em Crianças E Adolescentes Com Processo Inflamatório Com Desvio Nuclear À Esquerda

Peliser¹,

Merisio²

2015

Arq. Ciênc. Saúde Unipar

View full text Add to dashboard Cite

PELISER, N. C.; MERISIO, P. R. Análise da concentração de SICAM-1 em crianças e adolescentes com processo inflamatório com desvio nuclear à esquerda. Arq. Cienc. Saúde UNIPAR, Umuarama, v. 19, n. 2, p, 89-93, maio/ago. 2015 RESUMO: Os neutrófilos são fagócitos e atuam no processo de defesa do organismo iniciando a cascata inflamatória quando ativados. Este processo envolve vários fatores, entre eles a liberação de bastonetes e o aumento na concentração de sICAM-1. Verificou-se o estado de ativação do endotélio em 37 pacientes de 0 a 18 anos sem doenças crônicas, de modo a investigar um possível aumento de sICAM-1 com o aumento de bastonetes. Os bastonetes foram analisados por meio de verificação de prontuário. A determinação das concentrações séricas de sICAM-1 foi realizada por meio da técnica imunoenzimática (ELISA) direto. Foi possível notar que não há correlação entre o aumento de bastonete e o aumento da molécula sICAM-1 (r=0,28). Dividindo-se os pacientes em dois grupos, um que possui sICAM-1 alterado e outro que possui sICAM-1 normal, observou-se mediante os dados que estes possuem diferença notável de bastonetes (p=0,047), onde a média de bastonetes é maior no grupo sICAM-1 alterado. A presença de sICAM-1 aumentada, normalmente, está ligada a casos inflamatórios, mas a mudança na sua expressão pode sofrer influência de outros fatores, tais como o uso de anti-inflamatórios esteroidais e tabagismo. Uma possível explicação para não ter ocorrido o aumento de sICAM-1 nos pacientes estudados, é de que estes estejam utilizando medicamentos do tipo anti-inflamatórios esteroidais. Segundo a literatura, a sICAM-1 parece ser um bom marcador para lesão endotelial em pacientes com doenças cardiovasculares, sugere-se então um estudo mais aprofundado para estes casos. PALAVRAS-CHAVES: Neutrófilos. Endotélio. ELISA. ANALYSIS OF sICAM-1 CONCENTRATION IN CHILDREN AND TEENS WITH INFLAMMATORY PROCESS WITH NUCLEAR SHIFT TO THE LEFT ABSTRACTS:Neutrophils are phagocytes and act in the body's defense process initiating the inflammatory cascade when activated. This process involves several factors, including the release of band cells and the increase in the concentration of sICAM-1. The activation state of the endothelium in 37 patients from 0 to 18 years old with no chronic diseases was checked, in order to investigate a possible increase of sICAM-1 with increased band cells. The band cells were analyzed through an investigation of medical records. Determination of sI-CAM-1 serum concentrations was performed by direct enzyme immunoassay (ELISA). No correlation between the increase in band cells and increase the sICAM-1 molecule (r = 0.28) could be observed. By dividing the patients into two groups, one with changed sICAM-1 and the other presenting standard sICAM-1, it could be observed by the data they have notable difference in band cells (p = 0.047), where the average number of band cells is greater in the group with altered sICAM-1. The presence of increased sICAM-1 is typically linked to inflammatory cases, but the chang...

show abstract

Association of ICAM-1 K469E polymorphism with neurocysticercosis

Cited by 18 publications

References 33 publications

Immunopathogenesis of Neurocysticercosis: Role of Cytokines

Immunopathogenesis of Neurocysticercosis: Role of Cytokines

Correlations of ICAM-1 gene polymorphisms with susceptibility and multidrug resistance in colorectal cancer in a Chinese population

Análise Da Concentração De Sicam-1 Em Crianças E Adolescentes Com Processo Inflamatório Com Desvio Nuclear À Esquerda

Contact Info

Product

Resources

About