Association of Ideal Cardiovascular Health and Brachial–Ankle Pulse Wave Velocity: A Cross-Sectional Study in Northern China

Yan, Ning; Zhou, Yong; Wang, Youxin; Wang, Anxin; Yang, Xin; Russell, Alyce; Wu, Shouling; Wang, Wenjuan; Wang, Wei

doi:10.1016/j.jstrokecerebrovasdis.2015.08.031

Cited by 29 publications

(25 citation statements)

References 46 publications

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“…Our previous study based on the Jidong community indicated that the participants in the highest ideal CVH metrics summary score quartile had a 71% decreased prevalence of extracranial carotid artery stenosis (CAS) compared to those in the lowest summary score quartile . In addition, the ankle brachial index and brachial‐ankle pulse wave velocity were also demonstrated to be risk factors for CVH . Maintaining an ideal status of CVH risk factors with a focus on preventing the occurrence of risk factors is crucial for the prevention of CVDs …”

Section: Introductionmentioning

confidence: 99%

Ideal cardiovascular health metrics and the risk of non‐alcoholic fatty liver disease: A cross‐sectional study in northern China

Liu

Yao

Wang

et al. 2019

Liver International

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Background and purpose The components of ideal cardiovascular health (CVH) metrics have been shown to be associated with non‐alcoholic fatty liver disease (NAFLD). The present study aimed to determine the association between ideal CVH metrics and NAFLD. Methods A total of 10,511 participants (47.26% men) aged 18 to 92 years were selected from the Jidong and Kailuan communities. Ideal CVH was based on 7 ideal CVH metrics: smoking, body mass index (BMI), physical activity, diet, total cholesterol, blood pressure and fasting blood glucose. NAFLD was determined by abdominal ultrasonography. All participants underwent questionnaire assessments and clinical and laboratory examinations. Logistic regression models were used to analyse the relationship of CVH metrics and the number of ideal CVH metrics with NAFLD. Results The prevalence rates of NAFLD by CVH summary score quartiles were 64.38% (2,015/3,130), 50.16% (786/1,567), 33.28% (1,194/3,588) and 20.89% (465/2,226). Participants in the highest quartile showed a lower odds ratio (OR) than those in the lowest quartile (fully adjusted OR: 0.17, 95% CI: 0.17‐0.20, P < 0.001). Similar results were observed in subjects stratified by sex and age (45 years). The ORs were progressively decreased with an increased number of ideal CVH metrics (all P < 0.001). Conclusions NAFLD was significantly associated with both the summary score of CVH metrics and the number of ideal CVH metrics. The combined evaluation of ideal CVH may contribute to the prevention of NAFLD.

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Section: Introductionmentioning

confidence: 99%

Ideal cardiovascular health metrics and the risk of non‐alcoholic fatty liver disease: A cross‐sectional study in northern China

Liu

Yao

Wang

et al. 2019

Liver International

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“…Recent studies showed that the CVH behaviors and factors are relevant to atherosclerosis and cardiovascular events [16,17], but the relationship between CVH and CKD is less well understood. In addition, the occurrence and development of CKD take a long time, and many available data do not adequately assess the sustained effect of long-term cumulative exposure on CKD.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the exposure to cumulative cardiovascular health behaviors and factors and chronic kidney disease—The Kailuan study

Hou¹,

Li²,

Huang³

et al. 2018

PLoS ONE

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It is unclear whether ideal cardiovascular health (CVH) behaviors and factors, particularly cumulative exposure to ideal CVH (cumCVH), is associated with chronic kidney disease (CKD). The aim of the study was to examine the effect of cumCVH on CKD using the data from the Kailuan study. The study included the 27,970 (21,199 males) of the Kailuan community (China). The participants were 19 to 98 years of age. They were followed in 2008–2009, 2010–2011, and 2012–2013 by the same medical staff that did the initial physical examinations in 2006–2007. Participants were censored on the visit reporting CKD. A CVH score was created based on the seven AHA health metrics. The cumCVH score was CVH1×timev1-v2+CVH2×timev2-v3+CVH3×timev3-v4. In the fully adjusted model, compared with the lowest quintile of cumCVH, individuals in the highest quintile had a 75% lower risk of CKD (95% confidence interval (CI): 66–82%). Every additional year lived with a 1-unit increase in ideal CVH was associated with an 11% (95% CI: 9–13%) reduction in the incidence of CKD. Furthermore, when we excluded each of the six metrics from the cumCVH score in turn, the association was unaffected after the exclusion of individual risk factors. Ideal CVH is associated with a reduced incidence of CKD. Measurements of cumCVH are more likely to reflect the lifetime risk of CKD and possibly of other health outcomes.

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“…It has been demonstrated that there is a significant inverse association between arterial stiffness and further cardiovascular disease [17–19]. A decrease in PWV is considered to correlate with improved hypertension or ideal cardiovascular health [20]. Although increases in left ventricular mass index (LVMI) and left ventricular hypertrophy (LVH) has been detected in KCNJ5 -mutant carriers [21, 22], evidence evaluating the outcome of vascular status in those with KCNJ5 somatic mutations after adrenalectomy was insufficient.…”

Section: Introductionmentioning

confidence: 99%

Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy

Chang

Tsai

et al. 2017

Oncotarget

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The aim of this study was to show the effect of KCNJ5 mutational status on arterial stiffness in aldosterone-producing adenomas after adrenalectomy. Between February 2008 and January 2010, we prospectively enrolled 108 aldosterone-producing adenoma patients undergoing adrenalectomy. We conducted repeated measurements of pulse wave velocity at baseline, 6 months, and 12 months after adrenalectomy, grouped by KCNJ5 mutational status. Prognostic factors of arterial stiffness and risk for hypertension at 12 months after adrenalectomy were analyzed after propensity score matching in a 1:1 ratio. After matching for age, sex and body mass index, 88 patients were divided equally into KCNJ5-mutant and non-mutant groups. KCNJ5 mutational status was not an independent variable in either the generalized estimating equation model (p = 0.147) or the percentage change of brachial-ankle pulse wave velocity (p = 0.106). The generalized additive model smoothing plot showed that aldosterone-producing adenoma patients who carried the KCNJ5 mutation and were aged between 37 and 60 may have a hypertension recovery advantage. According to our observations during a 12-month follow-up after adrenalectomy, KCNJ5 mutational status was not associated with improvement in arterial stiffness.

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Association of Ideal Cardiovascular Health and Brachial–Ankle Pulse Wave Velocity: A Cross-Sectional Study in Northern China

Cited by 29 publications

References 46 publications

Ideal cardiovascular health metrics and the risk of non‐alcoholic fatty liver disease: A cross‐sectional study in northern China

Ideal cardiovascular health metrics and the risk of non‐alcoholic fatty liver disease: A cross‐sectional study in northern China

Relationship between the exposure to cumulative cardiovascular health behaviors and factors and chronic kidney disease—The Kailuan study

Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy

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