Association of IL-10 -1082A&gt;G, -819C&gt;T, and -592C&gt;A polymorphisms with susceptibility to chronic and aggressive periodontitis: a systematic review and meta-analysis

Mashhadiabbas, Fatemeh; Dastgheib, Seyed Alireza; Hashemzehi, Ahmad; Bahrololoomi, Zahra; Asadian, Fatemeh; Neámatzadeh, Hossein; Zare-Shehneh, Masoud; Daliri, Karim

doi:10.1007/s00011-021-01448-z

Cited by 10 publications

(6 citation statements)

References 51 publications

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“…This is consistent with the outcomes of our previous study on peri-implantitis [39]. In contrast, Mashhadiabbas et al [25] reported no significant association between risks of chronic and aggressive periodontitis with IL-10 ─ 819 C/T SNP. Differences between our outcomes and the previous studies might be attributed to racial differences [24,25].…”

Section: Discussionsupporting

confidence: 92%

“…The relationship between several SNPs and periodontitis has been questionable and more clinical data are needed to draw a reliable conclusion in this regard [22,23]. Furthermore, it is proved that the association between gene polymorphisms and periodontitis differs based on race [24,25]. However, there is relatively little evidence available on the Iranian population.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of interleukin 10, interleukin 1-beta, and tumor necrosis factor-alpha gene polymorphisms in patients with periodontitis and healthy controls

Saremi

Shafizadeh

Ghaffari

et al. 2022

Egypt J Med Hum Genet

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Background Chronic periodontitis (CP) is a prevalent infectious disease caused by an interplay between pathogens and immune responses. Gene polymorphisms are among the factors that affect susceptibility to CP. This study aimed to assess the association between CP and single nucleotide polymorphisms (SNPs) of interleukin-10 (IL-10), interleukin 1ß (IL-1ß), and tumor necrosis factor-α (TNF-α) genes. Methods A total of 87 patients with CP and 89 healthy controls were included in this study. Venous blood samples were obtained, and DNA was extracted and purified. Segments containing the relevant genes were amplified by polymerase chain reaction (PCR). Electrophoresis was performed after restriction fragment length polymorphism (RFLP) to determine genotype and allele frequencies. Results The CP group showed significantly different allele and genotype frequencies for three out of five SNPs: IL-10 ─ 592 C/A, IL-10 ─ 819 C/T, and IL-1ß + 3954 C/T (p < 0.05). Additionally, the frequency of the TNF-α ─ 857 AA genotype was significantly lower in patients compared with controls (p = 0.034); however, no significant differences were found in allele frequencies (p > 0.05). Logistic regression analysis revealed that carriers of IL-10 ─ 592 A allele and IL-1ß + 3954 T allele are at higher risk of CP (p < 0.001). Allele and genotype frequencies for TNF-α ─ 308 G/A did not differ significantly between patients and controls (p > 0.05). Conclusions This study showed specific genotypes of IL-10 ─ 592 C/A, IL-10 ─ 819 C/T, IL-1ß + 3954 C/T, and TNF-α ─ 857 G/A SNPs may be associated with an increased risk of CP development.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Evaluation of interleukin 10, interleukin 1-beta, and tumor necrosis factor-alpha gene polymorphisms in patients with periodontitis and healthy controls

Saremi

Shafizadeh

Ghaffari

et al. 2022

Egypt J Med Hum Genet

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“…The upregulation of TGF-β results in collagen production and reduces collagen-destroying MMP-1 production, which will be beneficial to protect against periodontitis ( 172 ). IL-10 polymorphism is of high clinical relevance and a valuable marker to recognize patients who are at higher risk for periodontitis ( 173 ). On the other hand, regulatory T cells play an important role in modulating the immunity in periodontitis patients by defending against inflammation and autoimmunity ( 174 ).…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis on Multiple Cytokine Gene Polymorphisms in the Pathogenesis of Periodontitis

Liu

2022

Front. Immunol.

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AimPeriodontitis is an inflammatory disease that destroys both soft and hard periodontal tissues. However, a complex periodontal cytokine network remains unclear. This systematic review explored multiple cytokine gene polymorphisms in the pathogenesis of periodontitis.Material and MethodsA systematic search was performed using the databases from previous publications, which indicated the association between cytokine polymorphisms and periodontitis pathogenesis. Meta-analysis was conducted using fixed or randomized models to calculate the significance of multiple cytokine polymorphisms. A total of 147 articles were analyzed with polymorphisms in 12 interleukins [Th1 (IL-2, IFN-γ, and TNF-α), Th2 (IL-4 and IL-13), Th17 (IL-1α, IL-1β, IL-6, and IL-17), and Treg cytokines (IL-10 and TGF-β)]. Doi plot was used to probe the occurrence of publication bias.ResultsThe polymorphisms of IL-2 and TNF-α of Th1 cytokine family may be associated with the pathogenesis or the prevention of periodontitis risk, while the polymorphism of IFN-γ is not related to periodontitis risk. The polymorphisms for IL-4 and IL-13 of Th2 cytokine family are not found to be associated with the pathogenesis of periodontitis. For the polymorphisms of the members of Th17 cytokine family, different IL-1α polymorphisms may have inverse actions in the pathogenesis of periodontitis. IL-1β is a noteworthy cytokine biomarker in periodontitis development and progression. IL-6 may have a protective function in the inflammatory responses of periodontitis, and IL-17 has a weak relationship the inflammatory responses. The polymorphisms for the members of Treg cell cytokines may have a protective function against periodontitis risk. LFK indexes show the major asymmetry due to publication bias.ConclusionIL-1β is a notable cytokine biomarker in periodontitis risk. Treg cytokines favor an anti-inflammatory and protective environment. Further data are needed to confirm the present conclusion due to publication bias.

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“…IL-10 is known to play a substantial role in inflammation and immune processes [24]. IL-10 has been reported to inhibit the production of proinflammatory cytokines tumor necrosis factor alpha (TNFα), interleukin 1α and β (IL1α and β), interleukin IL-6 (IL-6), and interleukin-8 (IL-8), while stimulating B-cell proliferations, differentiation, and production [25][26][27][28][29]. IL-10 is an immunomodulatory cytokine encoded by the IL-10 gene on chromosome 1q31-32, containing five exons separated by four introns, and its receptor is located on chromosome 11 [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Correlation between rs1800871, rs1800872 and rs1800896 Polymorphisms at IL-10 Gene and Lung Cancer Risk

Vakili,

Shirinzadeh-Dastgiri,

Ershadi

et al. 2024

Asian Pac J Cancer Prev

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Background: The tumorigenesis of lung cancer is complicated, and genetic factor may have the role in the malignant transformation of lung cells. IL-10 gene polymorphisms have been evaluated for their potential roles in lung cancer. However, those studies results are controversial. To clarify the effects of IL-10 rs1800871, rs1800872 and rs1800896 polymorphisms on the risk of lung cancer, a meta-analysis was performed with eligible individual studies. Methods: Eligible publications were gathered by retrieving PubMed, Web of Science, Embase, Wan Fang, and CNKI up to September 01, 2023. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of such association. Results: A total of 23 studies, including 5950 patients with lung cancer and 8046 healthy controls, were identified in this meta-analysis. Overall, there was no a significant association between the rs1800871, rs1800872 and rs1800896 polymorphisms at IL-10 gene and susceptibility to lung cancer globally when all studies in the pooled into this meta-analysis. Stratified analysis by ethnicity showed that rs1800872 polymorphism was associated with lung cancer among Asians and Caucasians. However, no significant association was identified between the rs1800871 and rs1800896 and risk of lung cancer. Conclusions: Pooled data showed that IL-10 rs1800871, rs1800872 and rs1800896 polymorphisms were not associated with lung cancer globally. Future well-designed large case-control studies with different ethnicities are recommended.

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Association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with susceptibility to chronic and aggressive periodontitis: a systematic review and meta-analysis

Cited by 10 publications

References 51 publications

Evaluation of interleukin 10, interleukin 1-beta, and tumor necrosis factor-alpha gene polymorphisms in patients with periodontitis and healthy controls

Evaluation of interleukin 10, interleukin 1-beta, and tumor necrosis factor-alpha gene polymorphisms in patients with periodontitis and healthy controls

A Systematic Review and Meta-Analysis on Multiple Cytokine Gene Polymorphisms in the Pathogenesis of Periodontitis

Correlation between rs1800871, rs1800872 and rs1800896 Polymorphisms at IL-10 Gene and Lung Cancer Risk

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