Association of IL-10, IL-18, and IL-33 genetic polymorphisms with recurrent pregnancy loss risk in Iranian women

Soheilyfar, Sorour; Nikyar, Tahereh; Maroufi, Nazila Fathi; Chamkhorami, Fariba Mohebi; Amini, Zahra; Ahmadi, Maryam; Azimian, Saba Haj; Isazadeh, Alireza; Taefehshokr, Sina; Taefehshokr, Nima

doi:10.1080/09513590.2018.1528220

Cited by 31 publications

(11 citation statements)

References 30 publications

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“…It has been reported that there was a significant correlation between IL‐18 (rs1946518) polymorphism and RPL in which the CC genotype can be a RPL risk factor among a subpopulation of Iranian cases. Moreover, they also observed the GA genotype of IL‐33 (rs1929992) polymorphism as a RPL risk factor among Iranian subjects (Soheilyfar et al, ). IL‐17 (OMIM: 603149) is produced by Th‐17 cells following IL‐23 induction.…”

Section: T‐helper Cytokinesmentioning

confidence: 95%

Genetics of recurrent pregnancy loss among Iranian population

Moghbeli

2019

Molec Gen & Gen Med

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Background Recurrent pregnancy loss (RPL) is one of the most common reproductive disorders which is defined as the occurrence of recurrent miscarriage before 24 weeks of gestation and is observed among 1%–5% of women. Methods Various factors are associated with RPL such as immunological disorders, maternal age, obesity, alcohol, chromosomal abnormality, endocrine disorders, and uterine abnormalities. About half of the RPL cases are related with chromosomal abnormalities. Therefore, RPL genetic tests are mainly limited to karyotyping. However, there is a significant proportion of RPL cases without any chromosomal abnormalities that can be related to the single‐gene aberrations. Therefore, it is required to prepare a diagnostic panel of genetic markers besides karyotyping. Results In the present review, we have summarized all the significant reported genes until now which are associated with RPL among Iranian women. We categorized all the reported genes based on their cellular and molecular functions in order to determine the molecular bases of RPL in this population. Conclusion This review paves the way of introducing a population‐based diagnostic panel of genetic markers for the first time among Iranian RPL cases. Moreover, this review clarifies the genetic and molecular bases of RPL in this population.

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Section: T‐helper Cytokinesmentioning

confidence: 95%

Genetics of recurrent pregnancy loss among Iranian population

Moghbeli

2019

Molec Gen & Gen Med

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“…Infertility is defined by the world health organization as a disorder of reproductive system that is one of the important problems in 10–15% of couple worldwide, which male infertility factors are responsible for 20–30% of all human infertility cases [ 1 , 2 ]. One of the common cause of the male infertility is defects in quality and quantity of sperm, which can occur by effects of genetic variants and environmental factors [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population

et al. 2022

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Background Male infertility is a heterogeneous disease which can occur due to spermatogenesis defects. The idiopathic azoospermia and oligospermia are the common cause of male infertility with unknown underlying molecular mechanisms. The aim of this study was to investigate association of idiopathic azoospermia and oligospermia with single-nucleotide polymorphisms of CATSPER1, SPATA16 and TEX11 genes in Iranian-Azeri men. Methods In this case–control study, we recruited 100 infertile men (case group) and 100 fertile men (control group) from Azeri population in north western provinces, Iran, population. The genomic DNA was extracted using a proteinase K method from peripheral blood leukocytes. The genotypes analysis was conducted using tetra-primer amplification refractory mutation system-polymerase chain reaction method. The obtained data were analyzed by statistical software. Results We found a significant difference in the frequencies of heterozygote AB and mutant homozygote BB genotypes in the CATSPER1 (rs2845570) gene polymorphism between patients and healthy controls (p < 0.05). Moreover, we observed a significant difference in the frequencies of heterozygote BA genotype in the SPATA16 (rs1515442) gene polymorphism between patients and healthy controls (p < 0.05). However, no significant difference was found in genotypes distribution of case and control groups in the TEX11 (rs143246552) gene polymorphism. Conclusion Our finding showed that the CATSPER1 (rs2845570) and SPATA16 (rs1515442) genes polymorphism may play an important role in idiopathic azoospermia and oligospermia in Iranian Azeri population. However, more extensive studies with larger sample sizes from different ethnic origins are essential for access more accurate results.

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“…Male infertility factors include a high proportion of all infertility cases that may be observed along with female infertility factors or alone (1,2). Male infertility is a complex problem that can occur due to environmental and genetic/epigenetic factors (3,4). Idiopathic male infertility includes approximately 40% of all male infertility cases that may be associated with genetic and genomic factors (5,6).…”

Section: Introductionmentioning

confidence: 99%

AURKC Gene Polymorphism (rs58264281) Associated with Idiopathic Male Infertility Risk in Northeast of Iran: A Case-Control Study

et al. 2021

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Background: Infertility is a major public health and social problem in human reproduction that is known as a multifactorial complex disorder. Genetic background and mutations and single nucleotide polymorphisms (SNPs) on the genes involved in sperm development are the important causes of male infertility. Objectives: In this study, we evaluated the association of AURKC gene polymorphism (rs58264281) and idiopathic male infertility in the Iranian Azeri population. Methods: This study was performed among 100 men with idiopathic infertility (case group) and 100 healthy men with successful fertility (control group) from East Azerbaijan, Iran. Genomic DNA extraction was carried out from peripheral blood samples by the proteinase K method. Genotype analysis was conducted by the tetra-primer amplification refractory mutation system-polymerase chain reaction (Tetra-ARMS PCR). SPSS version 21 was used for the analysis of the obtained data. Results: We observed that the CA and AA genotypes were significantly increased in patients with infertility as compared to healthy controls. Our results demonstrated that the mutant allele of AURKC gene polymorphism (rs58264281) was a significant risk factor in male infertility. Conclusions: We suggested a significant correlation between the AURKC gene rs58264281 polymorphism and male infertility in the Iranian Azeri population. However, further studies are required among other ethnicities, races, and geographic areas with larger sample sizes.

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Association of IL-10, IL-18, and IL-33 genetic polymorphisms with recurrent pregnancy loss risk in Iranian women

Cited by 31 publications

References 30 publications

Genetics of recurrent pregnancy loss among Iranian population

Genetics of recurrent pregnancy loss among Iranian population

Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population

AURKC Gene Polymorphism (rs58264281) Associated with Idiopathic Male Infertility Risk in Northeast of Iran: A Case-Control Study

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