Association of IL-18 polymorphisms with rheumatoid arthritis: a meta-analysis

Ll, Li; Xf, Deng; Jp, Li; Ning, Ning; Xl, Hou; Jl, Chen

doi:10.4238/gmr.15017389

Cited by 10 publications

(9 citation statements)

References 33 publications

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“…These polymorphisms may be associated with increased IL16 and IL18 synthesis in some patients and enhanced inflammatory response. Previous studies have shown that these polymorphisms may be associated with increased risk of inflammatory diseases [14]. The aim of this study was to examine the association between IL16 and IL18 gene polymorphisms and GDM.…”

Section: Introductionmentioning

confidence: 99%

IL16 and IL18 gene polymorphisms in women with gestational diabetes

Tarnowski

Wieczorek²,

Dziedziejko

et al. 2017

Ginekol Pol

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Objectives: Gestational diabetes mellitus is a carbohydrate intolerance that occurs during pregnancy. Various inflammatory mediators are considered to be risk factors leading to GDM development. Among them are pro-inflammatory cytokines, such as IL16 and IL18. The aim of this study was to examine the association between IL16 and IL18 polymorphisms and GDM. Material and methods:This study included 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT). All samples were genotyped in duplicate using allelic discrimination assays with TaqMan® probes.Results: We observed that there was a decreased frequency of IL16 rs4778889 CC genotype carriers among women with GDM (CC vs. CT + TT: OR = 0.14; 95% CI = 0.02-1.15; p = 0.034). However, there was no significant difference in the distribution of alleles (C vs. T: OR = 0.81; 95% CI = 0.54-1.21; p = 0.30). There was a decreased frequency of the IL18 rs187238 G allele among GDM women (G vs. C: OR = 0.71; 95% CI = 0.53-0.96; p = 0.027). We also observed a decreased frequency of the IL18 rs1946518 T allele among women with GDM; however, this difference had only borderline statistical significance. We observed an association between IL18 rs187238, rs1946518 and BMI in pregnant women. Conclusions:The results of this study suggest that IL18 rs187238 and rs1946518 polymorphisms may be associated with an increased risk of GDM as well as with BMI in pregnant women.

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Section: Introductionmentioning

confidence: 99%

IL16 and IL18 gene polymorphisms in women with gestational diabetes

Tarnowski

Wieczorek²,

Dziedziejko

et al. 2017

Ginekol Pol

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“…In RA, articular inflammation seems to be caused by the expression of inflammatory cytokines and chemokines that determine the activation and proliferation of the synovial lining, and by inflammatory cell recruitment and B cell activation with autoantibody production (Samson et al, 2012). The IL-1 family of cytokines (IL-1a, IL-1b, IL-18, and IL-33) are highly expressed in RA (Bessis et al, 2000;Li et al, 2016). Furthermore, IFN-b, TGFb, IL-4, and IL-13 increase the expression of IL-1Ra while diminishing the production of IL-1 (Chizzolini et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Identification of significant pathway cross-talk in rheumatoid arthritis by the Monte Carlo cross-validation method

Song

Zhang

et al. 2017

Genet. Mol. Res.

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We attempted to identify significant pathway cross-talk in rheumatoid arthritis (RA) by the Monte Carlo cross-validation (MCCV) method. We therefore obtained and preprocessed the gene expression profile of RA. MCCV involves identifying differentially expressed genes (DEGs), identifying differential pathways (DPs), calculating the discriminating score (DS) of the pathway cross-talk, and random forest (RF) classification. We carried out 50 bootstrap iterations of MCCV to identify the key instances of pathway cross-talk involved in RA. We identified a total of 17 significant DEGs and 15 significant DPs by comparing RA samples and normal controls. We found the most significant difference between RA and the normal controls in the eIF4 and p70S6K signaling regulation pathway. Furthermore, we identified 10 instances of pathway cross-talk with the best classification performance for RA and normal controls, using the RF classification model. All of the top 10 pathway pairs involved cross-talk with eIF4 and p70S6K signaling regulation, and the other 10 pathways were immune-related. By MCCV, we identified one critical DP and 10 significant instances of pathway cross-talk in RA. We propose that the eIF4 and p70S6K signaling regulation pathway and the other significant instances of pathway cross-talk play key roles in the occurrence and development of RA, and are potential predictive and prognostic markers for RA.

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“…Also, monocytes and macrophages in patients with rheumatic diseases, especially SLE, have increased expression of inflammasome components and/or enhanced inflammasome activation , suggesting the existence of an intrinsic alteration in the intracellular inflammasome pathways. Of note, some polymorphisms of inflammasome‐related genes have been shown to be associated with susceptibility, severity, and/or treatment response in rheumatic diseases, including SLE and RA . Improvement in disease activity was observed in murine models of SLE, RA, crystal‐induced arthropathies, and Sjögren's syndrome (SS) when inflammasome activation was targeted genetically or chemically (see details below).…”

Section: Introductionmentioning

confidence: 99%

“…Cytokine polymorphisms have not been definitive either. Polymorphisms of IL‐1β may be associated with the development of RA in certain ethnic populations , and IL‐18 polymorphisms may also increase the risk of RA . Overall, the relationship between RA and the inflammasome may reflect the inflammatory activity in the joint itself, rather than a true genetic etiology of the disease.…”

Section: Introductionmentioning

confidence: 99%

Advances in Disease Mechanisms and Translational Technologies: Clinicopathologic Significance of Inflammasome Activation in Autoimmune Diseases

Kahlenberg

Kang

2020

Arthritis & Rheumatology

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Autoimmune diseases are characterized by dysregulated immune tolerance to self and inflammatory damage to tissues and organs. The development of inflammation involves multiple innate and adaptive immune pathways. Inflammasomes are multimeric cytosolic protein complexes that form to mediate host immune responses upon recognizing pathogen‐ or damage‐associated molecular patterns via pattern‐recognition receptors (PRRs). The accelerating pace of inflammasome research has demonstrated important roles for inflammasome activation in many pathologic conditions, including infectious, metabolic, autoinflammatory, and autoimmune diseases. The inflammasome generally comprises a PRR, procaspase 1, and an adaptor molecule connecting the PRR and procaspase 1. Upon inflammasome activation, procaspase 1 becomes active caspase 1 that converts pro–interleukin‐1β (proIL‐1β) and proIL‐18 into mature and active IL‐1β and IL‐18, respectively. The cytokines IL‐1β and IL‐18 have multipotent effects on immune and nonimmune cells and induce and promote systemic and local inflammatory responses. Human studies have shown increased levels of these cytokines, altered activation of inflammasome‐related molecules, and/or the presence of inflammasome activators in rheumatic diseases, including systemic lupus erythematosus, rheumatoid arthritis, crystal‐induced arthropathies, and Sjögren's syndrome. Such changes are found in the primary target organs, such as the kidneys, joints, and salivary glands, as well as in the cardiovascular system. In animal models of rheumatic diseases, inflammation and tissue damage improve upon genetic or pharmacologic targeting of the inflammasome, supporting its pathogenic role. Herein, we review the clinicopathologic significance and therapeutic targeting of inflammasome activation in rheumatic diseases and related conditions based on recent findings.

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Association of IL-18 polymorphisms with rheumatoid arthritis: a meta-analysis

Cited by 10 publications

References 33 publications

IL16 and IL18 gene polymorphisms in women with gestational diabetes

IL16 and IL18 gene polymorphisms in women with gestational diabetes

Identification of significant pathway cross-talk in rheumatoid arthritis by the Monte Carlo cross-validation method

Advances in Disease Mechanisms and Translational Technologies: Clinicopathologic Significance of Inflammasome Activation in Autoimmune Diseases

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