Association of IL‐32 rs28372698 polymorphism with active chronic HBV infection

Abstract

Interleukin-32 (IL-32), a multiple proinflammatory cytokine, plays a vital role in immune-related diseases and infectious diseases. The promoter region of IL-32, which showed functional polymorphism, could regulate IL-32 expression. Although IL-32 rs28372698 polymorphism has been related to a lot of inflammatory diseases, the association of IL-32 rs28372698 polymorphism with a hepatic flare of chronic HBV infection has not been reported. In the present study, IL-32 rs28372698 polymorphism was genotyped in 104 chronic HBV carriers and 151 active chronic hepatitis B (CHB) patients. The frequency of IL-32 T/T genotype in patients with active CHB was significantly higher than that in chronic HBV carriers. Furthermore, the frequency of the T allele at IL-32 rs28372698 in active CHB patients was also higher than that in chronic HBV carriers. The serum level of IL-32 in active CHB patients was higher than that in chronic HBV carriers. Our results imply that IL-32 T/T polymorphism might be associated with a hepatic flare of chronic HBV infection.

A Paradoxical Effect of Interleukin-32 Isoforms on Cancer

“…Recently, several studies have demonstrated the impact of IL-32 polymorphisms on cancer progression. Moreover, IL-32 SNPs were studied and reviewed with their association to disease outcome (90)(91)(92)(93)(94)(95), and by 2021, one review performed a meta-analysis to evaluate the SNPs in malignancy (96). Up to now, three polymorphisms of IL-32 were found to be associated with the progression of several cancers that are rs28372698, rs12934561, and rs2015620 (Table 1).…”