Association of IL-6 -174G&gt;C and -572G&gt;C Polymorphisms with Susceptibility to Cervical Cancer and Ovarian Cancer

Hashemzehi, Ahmad; Karimi-Zarchi, Mojgan; Parsaeian, Seyedeh Fatemeh; Asadian, Fatemeh; Golestanpour, Hossein; Setayesh, Sepideh; Shaker, Seyed Amir; Zare-Shehneh, Masoud; Neámatzadeh, Hossein

doi:10.31557/apjcp.2021.22.9.2867

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…Warli et al detected that higher level of Il-6 correlated with metastases in lymph nodes in bladder cancer [ 53 ]. On the other hand, Hashemzehi et al observed an association of Il-6 -174G>C polymorphism with the risk of ovarian and also cervical cancer [ 54 ]. In 2020, Ahmed et al published a study about the association of TGF-ß1 rs 1880242 and Il-6 SNPs in the inflammatory process in ovarian cancer recurrence.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer

Bizoń,

Awiżeń-Panufnik,

Sawicki

2023

JPM

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The lack of specific symptoms in ovarian cancer delays onset of the diagnostic process. Hence, most cases are recognized in late stages of the disease. The aim of this study was to confirm the role of Il-6 compared to other markers in diagnosis and survival in ovarian cancer. The database was collected from 13 January 2021 to 15 February 2023. In total, 101 patients with pelvic tumors with a mean age of 57.86 ± 16.39 participated in the study. In every case, CA125, HE4, CEA, CA19-9, Il-6, C-reactive protein and procalcitonin measurements were taken. Patients with ovarian borderline tumor and metastatic ovarian tumors were excluded from further analysis. Statistically significant correlations were found between diagnosis of ovarian cancer and levels of CA125, HE4, CRP, PCT and Il-6. Comparison of Il-6 with other markers revealed that longer overall survival correlated with lower values of Il-6. In the case of a higher concentration of Il-6, OS and PFS were shorter. Sensitivity and specificity of Il-6 in diagnosis of ovarian cancer were 46.8% and 77.8%, respectively, while for CA125, CRP and PCT were 76.6% and 63%; 68% and 57.5%; 36% and 77%, respectively. More investigations are needed to identify the most specific and sensitive marker for ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer

Bizoń,

Awiżeń-Panufnik,

Sawicki

2023

JPM

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“…In 168 Brazilian patients, rs1800795 (G) allele frequency was higher in gastric cancer than in patients with chronic gastritis (Gatti et al, 2007). A recent study illustrated that that the IL-6 -174G>C polymorphism was associated with ovarian cancer and cervical cancer risk (Hashemzehi et al, 2021).…”

Section: Interleukin-6 Gene Polymorphism (Rs1800795)mentioning

confidence: 99%

Interleukins (IL-1A and IL-6) and the risk of Endometrial Carcinoma

Ramadan

Hemida

Mehanna

et al. 2022

Records of Pharmaceutical and Biomedical Sciences

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Endometrial carcinoma (EC) is a cancer that develops in the uterine or womb lining (Endometrium). It is the outcome of cells that have the capacity to move to other parts of the body growing abnormally. Hereditary causes account for 2-10% of all EC cases. Endometrial carcinoma develops as natural endometrial cell development is disrupted, new cells form unnecessarily, and old or weakened cells do not die when they should. The buildup of extra cells sometimes results in the formation of a mass of tissue known as a growth or tumor. This abnormal cancer cells have a number of genetic abnormalities that allow them to proliferate uncontrollably. Interleukins (ILs) are a subset of a larger group of cellular messenger molecules called cytokines, which are modulators of cellular behavior. Interleukins have role in therapeutics as well as diagnosis and prognosis as biomarker in various conditions. Additionally, it has been proposed that genetic polymorphisms in functionally important genes may be risk factors for the development of a number of malignancies, including endometrial cancer. This review pays attention to understand the risk of EC, and the importance of the effect of gene polymorphism (IL-6 rs1800795, and IL-1A rs1800587) on it. Also, their involvement in the etiology, pathogenesis, and outcome of the disease are explained, aiming to provide new insights into the pathogenesis of EC and the possibility to develop novel therapeutic approaches through targeting these genes.

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“… 8 Elevated levels of IL‐6 have been found in tumor tissues 9 , 10 , 11 and several single‐nucleotide polymorphisms (SNPs) in the IL‐6 gene have been implicated with increased risk of cervical cancer. 6 , 12 , 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

“…8 Elevated levels of IL-6 have been found in tumor tissues [9][10][11] and several singlenucleotide polymorphisms (SNPs) in the IL-6 gene have been implicated with increased risk of cervical cancer. 6,[12][13][14] Two promoter polymorphisms, rs1800795 (−174G/C) and rs1800797 (−597A/G), the IL-6 gene have been associated with a wide variety of malignancies, 15,16 including cervical cancer. 14,17,18 These two SNPs are located in the 5′ flanking region (7p15.3) of the IL-6 gene promoter.…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms of the interleukin‐6 (IL‐6) gene contribute to cervical cancer susceptibility in Bangladeshi women: A case‐control study

Shaswati

Oeishy

Mumu

et al. 2023

Health Science Reports

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Background and Aims Cervical cancer is characterized by abnormal cell growth in the lining of cervix and it is the second major cause of cancer‐related deaths among females in Bangladesh. Interleukin‐6 ( IL‐6 ) is a multifunctional cytokine that has been heavily linked with cervical cancer. Our aim was to investigate the association of two promoter single‐nucleotide polymorphisms (SNPs) of IL‐6 (rs1800795 and rs1800797) with the susceptibility of cervical cancer in Bangladeshi women. Methods DNA was extracted from venous blood samples from cervical cancer patients ( n = 126) and healthy controls ( n = 120). Polymerase chain reaction‐restriction fragment length polymorphism was used for genotyping of the selected SNPs. Logistic regression was performed to calculate the odds ratio (OR) with 95% confidence interval (CI) and p values. Results We found a significant association between rs1800795 and rs1800797 polymorphisms and cervical cancer. For, rs1800795 (G > C) the GC heterozygous genotype (OR = 2.80, 95% CI = 1.55–5.07, p = 0.0007) and CC mutant homozygous genotype (OR = 3.5, 95% CI = 1.29–9.51, p = 0.014) conferred an increased risk of cervical cancer. In case of rs1800797 (G > A) polymorphism, the AG heterozygous genotype (OR = 6.94, 95% CI = 3.76–12.81, p < 0.0001) and AA mutant homozygous genotype (OR = 3.88, 95% CI = 1.12–13.51, p = 0.0332) also exhibited an elevated risk of cervical cancer. Use of contraceptives was found as risk factor and patients who smoke were carriers of both the risk alleles and thus had an increased risk of cervical cancer. Conclusion Our findings suggest that polymorphism of rs1800795 and rs1800797 of the IL‐6 gene play a significant role in cervical cancer susceptibility in Bangladeshi women.

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Association of IL-6 -174G>C and -572G>C Polymorphisms with Susceptibility to Cervical Cancer and Ovarian Cancer

Cited by 8 publications

References 26 publications

Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer

Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer

Interleukins (IL-1A and IL-6) and the risk of Endometrial Carcinoma

Polymorphisms of the interleukin‐6 (IL‐6) gene contribute to cervical cancer susceptibility in Bangladeshi women: A case‐control study

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