Association of IL-6 and TGF-β Gene Polymorphisms with the Risk of Thoracolumbar Osteoporotic Vertebral Compression Fractures

Abstract

Purpose Osteoporotic vertebral compression fracture (OVCF) is a common disease in the elderly, and genetic factors play a key role in its occurrence. The present study was conducted to investigate the association between interleukin-6 ( IL-6 ) and the transforming growth factor ( TGF-β ) gene polymorphisms and the occurrence of thoracolumbar OVCF. Patients and Methods This case–control study recruited 146 patients with OVCF and 144 osteoporosis patients as the control group. Genotypes of the IL-6 rs1800796 and TGF-β rs1982073 were analyzed by sequencing. Genotype distribution and allelic frequencies were investigated by the χ 2 test. Odds ratios (OR) and 95% confidence intervals (CI) evaluated the relationship of IL-6 or TGF-β polymorphism and OVCF susceptibility. Results Allele G and genotype GG of IL-6 rs1800796 was more frequent in patients with OVCF (40.07% vs.28.47%; 19.18% vs.7.64%) compared with controls. GG genotype (OR=3.394, 95% CI=1.560–7.385, P < 0.001) and G allele (OR=1.680, 95% CI=1.187–2.376, P < 0.001) of IL-6 rs1800796 was significantly associated with increased risk of OVCF. What is more, CT and TT genotypes (41.78 vs.51.39; 19.86 vs.26.39) and allele T (40.75 vs 52.08) of TGF-β rs1982073 were less frequent in OVCFs, more common in controls and protective against OVCF risk (OR=0.436, 95% CI=0.228–0.835, P = 0.012; OR=0.615, 95% CI=0.443–0.855, P = 0.004). Conclusion Our results suggest that the G allele and GG genotype of IL-6 rs1800796 may contribute to increased susceptibility to OVCF in elderly Chinese. In contrast, CT and TT genotypes and the T allele of TGF-β rs1982073 may contribute to lower susceptibility of OVCF.

Role of SNPs of IL6 gene in the incidence and progression of COVID19 patients in Wasit province

“…Additional IL-6 SNPs were not investigated in this research [7], [8]. We suggest doing research on IL-6 genetic variants and COVID-19 pathogenesis in populations of various ethnicities so that these results may be verified [1], [7], [14]- [17], [21].…”

“…HBV has been linked to the genetic variant rs1800796. The role of rs13306435 in HCC has been confirmed by meta-analysis (HCC) [1], [7], [21]. SNPs rs13306435 (-395T > A), rs2069860 (-623A > T), and rs2069830 (-612A > T) were shown to have a substantial correlation with cervical cancer susceptibility in the Lithuanian population in a separate research that evaluated two IL-6 genetic polymorphisms (rs13306435 and rs2069830) [6], [15], [16].…”

“…The TT genotype is connected with poor IL-6 production and an attenuated immune response to chronic HCV infection. High blood IL-6 levels and SVR in HCV and HIV co-infected patients are related with the AA genotype of rs13306435174 A/T rs2069830 395 A/T [6], [14], [21]. There was no association found between the IL-6 rs13306435 (-572 A > T) polymorphism in an Egyptian population with either HCV infection or HCC.…”

Analysis of Gene Single Nucleotide Polymorphisms in COVID-19 Disease Highlighting the Susceptibility and the Severity towards the Infection

“…Though little is known regarding IL-6 polymorphisms and the pathogenesis of idiopathic pulmonary fibrosis in SARS-CoV-2 infections, data tend to confirm that the IL-6 174 is associated with elevated inflammatory patterns in the outcome of SARS-CoV-2 pneumonia. This event could be explained by the direct impact on CD4 and CD8 T cell fate exerted by IL-6 174 [ 35 , 36 , 37 , 38 , 39 , 40 , 41 ].…”

“…IL-6 R may control and modulate the pleiotropic activities of IL-6 through the membrane-bound and soluble forms, known as classic and trans-signaling, respectively. Of note, IL-6 R is primarily expressed by microglia in the central nervous system (CNS), which allowed scientists to hypothesize that alterations of the D358A variant in the ratio of transmembrane to soluble IL-6R may lead to genetic changes detectable in neurodegenerative diseases [ 12 , 13 , 14 , 15 , 16 , 17 , 36 , 37 , 38 , 43 , 44 , 45 ].…”