Association of IL-6 promoter polymorphism hotspots (− 174G/C and − 572G/C) with cardiovascular disease risk factors

Tabrez, Shams; Jabir, Nasimudeen R.; Zughaibi, Torki A.; Suhail, Mohd

doi:10.1007/s11033-021-07048-8

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…Indeed, the frequency of Allele G is, for example, 98% among Africans and 42% among Europeans. However, if we estimate the frequency of the G allele exclusively among the Caucasians of the hospitalized and non-hospitalized subgroups, the frequencies, 28% and 25%, respectively, are very similar, showing no statistical significance (as shown in Supplementary Table S1 [ 18 , 19 , 20 ]). The same could be observed among the other ancestry-related phenotypes (Blacks and Browns).…”

Section: Discussionmentioning

confidence: 98%

“…The first suggests that European ancestry is a risk factor for hospitalization and COVID-19 severity. The second putative implication is that the lower frequency of the G allele among those hospitalized could be a consequence of the fact that the G allele is less frequent among Europeans than among non-Europeans [ 18 ]. Indeed, the frequency of Allele G is, for example, 98% among Africans and 42% among Europeans.…”

Section: Discussionmentioning

confidence: 99%

“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/v15051197/s1, Supplementary Table S1. Minor Allele Frequencies of studied SNP in different ethnic worldwide populations were obtained from the ENSEMBL database [18][19][20] and in Non-Hospitalized and Hospitalized patients subgroups, according to their ethnic classification. Informed Consent Statement: All participants were informed about the study objectives and signed an informed consent form.…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…The following supporting information can be downloaded at: , Supplementary Table S1. Minor Allele Frequencies of studied SNP in different ethnic worldwide populations were obtained from the ENSEMBL database [ 18 , 19 , 20 ] and in Non-Hospitalized and Hospitalized patients subgroups, according to their ethnic classification.…”

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confidence: 99%

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Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

Rodrigues

Silva

Santos

et al. 2023

Viruses

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Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an important regulator of the cytokine storm. Hence, the evaluation of the influence of polymorphisms in key genes of the IL-6 pathway, namely IL6, IL6R, and IL6ST, may provide valuable prognostic/predictive markers for COVID-19. The present cross-sectional study genotyped three SNPs (rs1800795, rs2228145, and rs7730934) at IL6. IL6R and IL6ST genes, respectively, in 227 COVID-19 patients (132 hospitalized and 95 non-hospitalized). Genotype frequencies were compared between these groups. As a control group, published data on gene and genotype frequencies were gathered from published studies before the pandemic started. Our major results point to an association of the IL6 C allele with COVID-19 severity. Moreover, IL-6 plasmatic levels were higher among IL6 CC genotype carriers. Additionally, the frequency of symptoms was higher at IL6 CC and IL6R CC genotypes. In conclusion, the data suggest an important role of IL6 C allele and IL6R CC genotype on COVID-19 severity, in agreement with indirect evidence from the literature about the association of these genotypes with mortality rates, pneumonia, and heightening of protein plasmatic levels pro-inflammatory driven effects.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Supplementary Materialsmentioning

confidence: 99%

mentioning

confidence: 99%

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Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

Rodrigues

Silva

Santos

et al. 2023

Viruses

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“…They are associated with IL-6 concentrations, aging musculoskeletal function, chronic illnesses, immunological regulation, and depression. [5][6][7][8][9][10][11][12] Some studies suggests that these SNPs may also be linked to longevity in the elderly. [13] Therefore, we selected these 3 SNPs to investigate the significance of the 3 IL-6 variants in the risk of frailty in the elderly population.…”

Section: Introductionmentioning

confidence: 99%

Association of single nucleotide polymorphisms of IL-6 gene with frailty in the Chinese Bai nationality

Li,

Yang,

Meng

et al. 2023

Medicine

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To investigate the impact of 3 single nucleotide polymorphisms (SNPs) in the interleukin-6 (IL-6) gene and their interaction on susceptibility to frailty in the elderly in rural areas of China Bai nationality. Taking the Bai people in Dali, China as the research object, and according to the frailty phenotype scale, there were 2 groups: frail and non-frail. Basic information about the study participants was gathered using a questionnaire. Clinical biochemical indices were also evaluated and the Sanger method was used to identify the sequences of the IL-6 gene loci at rs1524107, rs1800796, and rs10499563. SHEsis online software was used to analyze the linkage disequilibrium of IL-6 gene sites and the relationship between haploids and frailty. The MDR software was used to analyze the 3 sites and their interactions. Among 231 rural Bai elderly people, 63 (27.3%) were frail and 168 (72.7%) were non-frail. The SNPs of rs1524107, rs1800796, and rs10499563 in the IL-6 gene were not associated with the occurrence of frailty, nor were they associated with clinical indicators such as grip strength and gait speed. After adjusting for age and gender, there was no significant difference in the distribution of the 3 genetic models composed of the 3 SNPs between frail and non-frail populations (all P > .05). The 3 haplotypes were not associated with the occurrence of frailty, and the interaction between the 3 loci was not associated with the susceptibility to frailty. The SNP of rs1524107, rs1800796, and rs10499563 sites of IL-6 gene may not be related to frailty susceptibility in Dali Bai people. Differences in frailty mechanisms among other populations at the gene level, which are of enormous significance for the prevention and treatment of frailty, require further research with larger samples and more gene loci.

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Estimating Anticancer Effects of Yohimbine in DMBA‐Induced Oral Carcinogenesis Hamster Model: Utilizing Biochemical and Immunohistochemical Techniques

Jabir,

Tabrez,

Altwaijry

et al. 2024

Cell Biochemistry & Function

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Yohimbine is a potent bioactive indole alkaloid, isolated from a variety of biological sources and has long been used as a natural stimulant and aphrodisiac, particularly to treat erectile dysfunction. However, some literature also points toward its anticancer effect in different experimental models. The current study aimed to address a clinical concern on the therapeutic utilization of yohimbine as a repurposed drug. We employed 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced hamster buccal pouch carcinogenesis model juxtaposed with biochemical investigation of several detoxification and antioxidant markers, such as Cyt p450, Cyt b5, thiobarbituric acid reactive substance (TBARS), glutathione (GSH), glutathione reductase (GR), glutathione S transferase (GST), DT‐diaphorase, vitamin C, vitamin E, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). The immunohistochemical assessment of cyclooxygenase‐2 (COX‐2), interleukin‐6 (IL‐6), proliferating cell nuclear antigen (PCNA), and cyclin D1 expression were also performed to observe the effect of yohimbine on these markers. The hamsters treated with DMBA presented the growth of tumors in the buccal pouches, accompanied by significant changes in the liver and buccal mucosa levels of Phase I & II detoxification enzymes and lipid peroxidation (LPO). A significant rise in the range of 2‐ to 3.5‐fold was observed in Cyt p450, Cyt b5, and LPO in DMBA‐treated animals. However, oral administration of yohimbine significantly restored the LPO, antioxidant, and detoxifying enzyme activities. Additionally, the levels of COX‐2, IL‐6, PCNA, and cyclin D1 were also found to be downregulated by yohimbine treatment. In conclusion, yohimbine improved the biochemical and immunohistochemical markers of DMBA‐induced oral cancer and reverted to near normal values via ameliorating the underlying inflammation and oxidative stress conditions. Our study highlighted the potential of yohimbine as anticancer agent, especially against oral cancer and suggested its possible use as repurposed drug.

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Association of IL-6 promoter polymorphism hotspots (− 174G/C and − 572G/C) with cardiovascular disease risk factors

Cited by 6 publications

References 35 publications

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

Association of single nucleotide polymorphisms of IL-6 gene with frailty in the Chinese Bai nationality

Estimating Anticancer Effects of Yohimbine in DMBA‐Induced Oral Carcinogenesis Hamster Model: Utilizing Biochemical and Immunohistochemical Techniques

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