Association of IL28B single nucleotide polymorphism rs8099917 with response to treatment in genotype 3 HCV-infected patients from India

Chinnaswamy, Sreedhar

doi:10.7869/tg.187

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…Similar result for minor allele frequency was also reported for Indian populations in a study conducted earlier using one SNP only in a healthy control group (0.238 for rs12979860 T allele) from southern region of India, the state of Andhra Pradesh [27] and pooled samples CHC cases (0.17 for rs8099917 G allele) [7]. We have derived haplotypes from both SNPs in healthy control and CHC cases by LD plot to determine population divergence to assess whether alleles at flanking loci on the same chromosomes tend to be inherited together or are there any associated ancestral recombination events.…”

Section: Discussionsupporting

confidence: 87%

IFNL4 haplotype, linkage disequilibrium and their influence on virological response to hepatitis C virus infection in Indian population

et al. 2019

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Type III interferon (IFNs) encoded by IFN lambda (IFNL) genes induce antiviral activity. The IFNL clusters include IFNL1/IL29, IFNL2/IL28A, IFNL3/IL28B and IFNL4 genes. The single nucleotide polymorphisms (SNPs, rs12979860 and rs8099917) associated with virological responses against hepatitis C virus (HCV) infections are recently mapped to IFNL4 gene. The IFNL gene polymorphisms also plays role in immune clearance, inflammation and risk of developing hepatocellular carcinoma. There is significant genetic heterogeneity of IFNL4 polymorphisms among ethnic populations that need to be regionally studied for viral infection, treatment response and relapse. The IFNL4 risk allele, genotype and haplotype frequencies across north Indian cohort were determined among chronic hepatitis C (CHC) cases (n = 141) and healthy controls (n = 111) by allele specific real-time PCR. Odds ratio was calculated for HCV exposure and treatment response using dominant and minor allele/genotype as reference. Non-random associations of these two SNP loci were evaluated by linkage disequilibrium plot. The minor allele (T) frequency of rs12979860C/T is 0.241 and 0.229; and minor allele (G) frequency for SNP rs8099917T/G is 0.174 and 0.171 among CHC cases and healthy control respectively. Coefficient of linkage disequilibrium (D 0 ) of these two SNPs is very high (D 0 = 0.98, r 2 [ 0.6) in CHC group than in healthy control (D 0 = 0.76, r 2 = 0.39) which indicate that both SNPs are strongly linked in CHC population than healthy control. Favorable association of IFNL4 haplotype (C-T), genotype (CC for rs12979860 and TT for rs8099917) with anti HCV therapy were found significant (p = 0.009, 0.021 and 0.001) for SVR. Favorable genotypes are also found to be predominant across the Indian study population.

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Section: Discussionsupporting

confidence: 87%

IFNL4 haplotype, linkage disequilibrium and their influence on virological response to hepatitis C virus infection in Indian population

et al. 2019

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“…Furthermore there are certain genetic variations especially the one near the IL-28B gene have been associated with response to HCV therapy with peg-Interferon and ribavirin. Though these IL-28B gene polymorphisms may have a lesser role to play in the era of DAAs certain studies [22,23] have shown that such gene polymorphisms are associated with virolological response rates in both genotype 1 and genotype 3.…”

Section: Genotypementioning

confidence: 99%

Management of Hepatitis C in the Indian Context: An Update

Bhattacharya¹,

Roy²

2015

J Liver

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“…[ 4 8 10 11 12 13 27 ] Such studies are of paramount importance for better diagnosis, prognosis and management of disease. [ 28 29 30 ]…”

Section: Discussionmentioning

confidence: 99%

Distribution of cytokine gene single nucleotide polymorphisms among a multi-ethnic Iranian population

et al. 2015

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Background:Cytokine gene single nucleotide polymorphisms (SNPs) are widely used to study susceptibility to complex diseases and as a tool for anthropological studies.Materials and Methods:To investigate cytokine SNPs in an Iranian multi-ethnic population, we have investigated 10 interleukin (IL) SNPs (IL-1β (C-511T, T-31C), IL-2 (G-384T), IL-4 (C-590T), IL-6 (G-174C), IL-8 (T-251A), IL-10 (G-1082A, C-819T, C-592A) and tumor necrosis factor-alpha (TNF-α) (G-308A) in 415 Iranian subjects comprising of 6 different ethnicities. Allelic and genotypic frequencies as well as Hardy-Weinberg equilibrium (HWE) were calculated by PyPop software. Population genetic indices including observed heterozygosity (Ho), expected heterozygosity (He), fixation index (FIS), the effective number of alleles (Ne) and polymorphism information content (PIC) were derived using Popgene 32 software. Multidimensional scaling (MDS) was constructed using Reynold's genetic distance obtained from the frequencies of cytokine gene polymorphism.Results:Genotypic distributions were consistent with the HWE assumptions, except for 3 loci (IL-4-590, IL-8-251 and IL-10-819) in Fars and 4 loci (IL-4-590, IL-6-174, IL-10-1082 and TNF-α-308) in Turks. Pairwise assessment of allelic frequencies, detected differences at the IL-4-590 locus in Gilakis versus Kurds (P = 0.028) and Lurs (P = 0.022). Mazanis and Gilakis displayed the highest (Ho= 0.50 ± 0.24) and lowest (Ho= 0.34 ± 0.16) mean observed heterozygosity, respectively.Conclusions:MDS analysis of our study population, in comparison with others, revealed that Iranian ethnicities except Kurds and Mazanis were tightly located within a single cluster with closest genetic affinity to Europeans.

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Association of IL28B single nucleotide polymorphism rs8099917 with response to treatment in genotype 3 HCV-infected patients from India

Abstract: Background and aim:IL28B gene polymorphisms have been associated with treatment-response (sustained virological response, SVR) in genotype 1 hepatitis C virus (HCV)-infected patients,

Cited by 6 publications

References 38 publications

IFNL4 haplotype, linkage disequilibrium and their influence on virological response to hepatitis C virus infection in Indian population

IFNL4 haplotype, linkage disequilibrium and their influence on virological response to hepatitis C virus infection in Indian population

Management of Hepatitis C in the Indian Context: An Update

Distribution of cytokine gene single nucleotide polymorphisms among a multi-ethnic Iranian population

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