Association of inappropriate left ventricular mass with systolic and diastolic dysfunctionThe HyperGEN study

DESIMONE, G; Kitzman, DalaneW; Palmieri, Vittorio; LIU, J; Oberman, Albert; Hopkins, Paul N.; Bella, Jonathan N.; Rao, D.V.; Arnett, Donna K.; Devereux, R B

doi:10.1016/s0895-7061(04)00818-0

Cited by 45 publications

(52 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…21,22 Chinali et al 9 have demonstrated that inappropriate LVM is associated with low LVEF, long isovolumic relaxation time and prolonged E-deceleration time in 359 hypertensive patients. Our study also demonstrated that concentric and eccentric LVH, LVEFo50% and mwFSo14% were significantly associated with increased observed/predicted LVM, consistent with previous findings.…”

Section: Discussionmentioning

confidence: 99%

“…Our study also demonstrated that concentric and eccentric LVH, LVEFo50% and mwFSo14% were significantly associated with increased observed/predicted LVM, consistent with previous findings. 21,22 Inappropriate LVM is associated with clusters of markers of cardiovascular risk. 21,22 Recently, an adverse impact of inappropriate LVM on cardiovascular outcomes has been observed in hypertensive patients.…”

Section: Discussionmentioning

confidence: 99%

“…21,22 Inappropriate LVM is associated with clusters of markers of cardiovascular risk. 21,22 Recently, an adverse impact of inappropriate LVM on cardiovascular outcomes has been observed in hypertensive patients. 10,11 For instance, de Simone et al 10 studied the impact of inappropriate LVM on cardiovascular prognosis in 294 hypertensive patients and found that inappropriate LVM predicted poor cardiovascular prognosis independently of age and systolic blood pressure.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The ratio of observed to predicted left ventricular mass is independently associated with increased cardiovascular events in patients with chronic kidney disease

et al. 2012

View full text Add to dashboard Cite

A condition involving the growth of the myocardium that exceeds hemodynamic needs has been reported and called as inappropriate left ventricular mass (LVM). The appropriateness of LVM can be estimated by the ratio of observed LVM to predicted LVM. The excessive growth of LVM is frequently noted in patients with chronic kidney disease (CKD). This study is designed to assess whether the ratio of observed to predicted LVM is a useful prognostic indicator of cardiovascular events in patients with moderate to advanced CKD. We consecutively enrolled 485 patients with CKD stages 3-5 from our Outpatient Department of Internal Medicine. Inappropriate LVM was defined as observed LVM more than 28% greater than the predicted value. The relative risk of cardiovascular events was analyzed by Cox-regression methods. There was a significant trend for a stepwise increase in the observed/predicted LVM ratio (Po0.001) and the prevalence of inappropriate LVM (P ¼ 0.003) corresponding to advances in CKD stages. In the multivariate analysis, old age, a history of coronary artery disease, congestive heart failure, atrial fibrillation, wide pulse pressure, decreased serum albumin and hemoglobin levels, left atrial diameter 44.7 cm and increased observed/predicted LVM were independently associated with increased cardiovascular events. Our findings show that increased observed/predicted LVM is independently associated with adverse cardiovascular outcomes in patients with CKD stages 3-5.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The ratio of observed to predicted left ventricular mass is independently associated with increased cardiovascular events in patients with chronic kidney disease

et al. 2012

View full text Add to dashboard Cite

show abstract

“…18-25 However, these relationships have largely been demonstrated in cross-sectional studies [18][19][20][21][22][23][24] and are at odds with on-treatment decreases in systolic LV chamber function associated with LVH regression. 16 Inverse LVM inappr ϪLV systolic chamber function relations 18-24 may, therefore, reflect compensatory increases in LVM as a consequence of systolic dysfunction or associated confounding effects.…”

Section: Abstract-althoughmentioning

confidence: 99%

Relationship Between On-Treatment Decreases in Inappropriate Versus Absolute or Indexed Left Ventricular Mass and Increases in Ejection Fraction in Hypertension

Woodiwiss

Libhaber

et al. 2012

Hypertension

View full text Add to dashboard Cite

Abstract-Although) LVMI decreased with treatment, treatment failed to increase EF in either group (1.2Ϯ10.8% and 2.7Ϯ10.7%, respectively). In contrast, in patients with inappropriate LV hypertrophy (LVM inappr Ͼ150%; nϭ33) LVM inappr decreased (Ϫ32Ϯ27%; PϽ0.0001) and EF increased (5.0Ϯ10.3%; PϽ0.05) after treatment, whereas in patients with an LVM inappr Յ150% (nϭ135), neither LVM inappr (Ϫ0.5Ϯ23%) nor EF (0.9Ϯ10.3%) changed with therapy. With adjustments for circumferential LV wall stress and other confounders, whereas on-treatment decreases in LVM or LVMI were weakly related to an attenuated EF (partial rϭ0.17; PϽ0.05), on-treatment decreases in LVM inappr were strongly related to increases in EF even after further adjustments for LVM or LVMI (partial rϭϪ0.63 [CI, Ϫ0.71 to Ϫ0.52]; PϽ0.0001). In conclusion, decreases in LVM inappr are strongly related to on-treatment increases in EF beyond changes in LVM and LVMI. LV hypertrophy can, therefore, be viewed as a compensatory change that preserves EF, but when in excess of that predicted by stroke work, it can be viewed as a pathophysiological process accounting for a reduced EF. 1-7 and the development of a reduced ejection fraction (EF) 8 independent of myocardial infarction. LV mass (LVM) may, therefore, determine the progression to heart failure with a reduced rather than a preserved EF. 9,10 However, in keeping with the classic tenet that LVH is a compensatory response to LV load, an increased LVM 11-13 or on-treatment decreases in LVM 14 have been associated with an unchanged EF. Moreover, LVH may even be associated with an enhanced EF for that predicted by wall stress, 15 and on-treatment decreases in LVM have been related to reductions rather than increases in indices of systolic LV chamber function. 16 There is, therefore, considerable uncertainty as to whether LVH contributes to decreases in systolic chamber function.One possibility that may explain discrepancies in the ability to show consistent relations between LVM or LVM index (LVMI) and a reduced systolic LV chamber function [11][12][13][14][15][16] is that absolute LVM and LVMI may incorporate a component of LVH considered compensatory in nature, whereas there may also be a component of LVH that contributes to decompensation. In this regard, LVM in excess of that predicted by workload (ie, stroke workϭblood pressure [BP]ϫstroke volume), termed "inappropriate LVM" (LVM inappr ), 17 is inversely associated with systolic LV chamber function.18-25 However, these relationships have largely been demonstrated in cross-sectional studies [18][19][20][21][22][23][24] and are at odds with on-treatment decreases in systolic LV chamber function associated with LVH regression. 16 Inverse LVM inappr ϪLV systolic chamber function relations 18-24 may, therefore, reflect compensatory increases in LVM as a consequence of systolic dysfunction or associated confounding effects. Although one previous study has reported that on-treatment regression but not persistence of LVM inappr is associated with an improved EF, 25 wh...

show abstract

“…[3][4][5] iVMI has also been reported to be associated with diastolic dysfunction, which can be demonstrated using various transmitral blood flow parameters. [6] The objective of this study was to evaluate the frequency of iLVM and factors associated with iLVM in HT patients with MetS.…”

Section: Introductionmentioning

confidence: 99%

Left Ventricular Mass Appropriateness in Hypertensive Patients with Metabolic Syndrome

Srojidinova¹

2016

Int J Biomed

View full text Add to dashboard Cite

The objective of this study was to evaluate the frequency of inappropriate left ventricular (LV) mass (iLVM) and factors associated with iLVM in hypertensive patients with metabolic syndrome (MetS). The study included 178 male patients (mean age 45.9±10.5 yrs) with hypertension (HT) and MetS. iLVM in HT patients with MetS was associated with LV diastolic dysfunction and an intensity of vascular remodeling process. Hyperinsulinemia contributes to LVM appropriateness, which aggravates the cardiovascular remodeling with development of the significant LV diastolic dysfunction and endothelium dysfunction. (Int J Biomed. 2016;6(3):170-173.).

show abstract

Association of inappropriate left ventricular mass with systolic and diastolic dysfunctionThe HyperGEN study

Cited by 45 publications

References 0 publications

The ratio of observed to predicted left ventricular mass is independently associated with increased cardiovascular events in patients with chronic kidney disease

The ratio of observed to predicted left ventricular mass is independently associated with increased cardiovascular events in patients with chronic kidney disease

Relationship Between On-Treatment Decreases in Inappropriate Versus Absolute or Indexed Left Ventricular Mass and Increases in Ejection Fraction in Hypertension

Left Ventricular Mass Appropriateness in Hypertensive Patients with Metabolic Syndrome

Contact Info

Product

Resources

About