2014
DOI: 10.1093/bja/aeu192
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Association of increased postoperative opioid administration with non-small-cell lung cancer recurrence: a retrospective analysis

Abstract: This retrospective analysis suggests an association between increased doses of opioids during the initial 96 h postoperative period with a higher recurrence rate of NSCLC within 5 yr.

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Cited by 86 publications
(72 citation statements)
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“…This is consistent with a previous study that opioid use during surgery in lung cancer is not associated with recurrence-free survival [7]. Furthermore, our study was characterized by the use of multivariate regression analysis to calculate all opioid use for a total of 7 days up to POD 0–6, which is a relatively long period of opioid use compared to previous studies [7, 8]. …”
Section: Discussionsupporting
confidence: 89%
See 2 more Smart Citations
“…This is consistent with a previous study that opioid use during surgery in lung cancer is not associated with recurrence-free survival [7]. Furthermore, our study was characterized by the use of multivariate regression analysis to calculate all opioid use for a total of 7 days up to POD 0–6, which is a relatively long period of opioid use compared to previous studies [7, 8]. …”
Section: Discussionsupporting
confidence: 89%
“…Based on these assumptions, a previous study by Maher et al [8] reported that a group of 99 recurrent patients who underwent VATS lung cancer surgery had greater postoperative opioid use than the non-recurrent group. Interestingly, this study also found an association between total opioid use and lung cancer recurrence with a hazard ratio of 1.003 (95% CI 1.000–1.006, P = 0.04), similar to that seen in our study [8].…”
Section: Discussionmentioning
confidence: 99%
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“…Other potential complications related to high dose opioids include an increased risk of deep vein thrombosis, gastrointestinal, infectious, and urinary complications [19]. Furthermore, studies have shown that high dose opioids can increase the risk of recurrence of certain types of cancer which has been attributed to the immunosuppressive effects of opioids [20,21]. Concerningly, high dose opioids have been linked with opioid overdose death in acute and chronic pain.…”
Section: Discussionmentioning
confidence: 99%
“…Intraoperative opioid use is associated with decreased overall survival (OS) in stage I but not stage II-III NSCLC patients [73]. There has been an association between increased doses of opioids during the initial 96 hours postoperative period with a higher recurrence rate of NSCLC within 5 years which could be related to suppression of natural killer cells by opioid analgesics [74]. However, a study from single institution recently revealed that opioids were found to have no negative influence on survival time [75].…”
Section: Opioidsmentioning
confidence: 99%