Association of increased risk of cardiovascular diseases with higher levels of perfluoroalkylated substances in the serum of adults

Feng, Xinghui; Long, Guangfeng; Zeng, Guowei; Zhang, Qi; Song, Binqian; K, Wu

doi:10.1007/s11356-022-22021-z

Cited by 23 publications

(7 citation statements)

References 71 publications

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“…71 Our prior investigations have already indicated that PFOS disrupts the directed differentiation of hESCs into skin, 74 corroborating the notion that PFOS is likely to contribute to poor wound healing, a disease associated with the skin. Moreover, previous research has linked PFOS exposure to eye diseases 72 and cardiovascular diseases, 73 consistent with the organ-specific diseases identified as recurrent corneal erosions and hypoplastic heart in our GSEA analysis.…”

Section: Discussionsupporting

confidence: 90%

Assessment and Comparison of Early Developmental Toxicity of Six Per- and Polyfluoroalkyl Substances with Human Embryonic Stem Cell Models

Zhao,

Yin,

Yang

et al. 2024

Environ. Sci. Technol.

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Per-and polyfluoroalkyl substances (PFAS) are extensively utilized in varieties of products and tend to accumulate in the human body including umbilical cord blood and embryos/ fetuses. In this study, we conducted an assessment and comparison of the potential early developmental toxicity of perfluorooctanoic acid (PFOA), undecafluorohexanoic acid (PFHxA), heptafluorobutyric acid, perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate, and perfluorobutyric acid at noncytotoxic concentrations relevant to human exposure using models based on human embryonic stem cells in both three-dimensional embryoid body (EB) and monolayer differentiation configurations. All six compounds influenced the determination of cell fate by disrupting the expression of associated markers in both models and, in some instances, even led to alterations in the formation of cystic EBs. The expression of cilia-related gene IFT122 was significantly inhibited. Additionally, PFOS and PFOA inhibited ciliogenesis, while PFOA specifically reduced the cilia length. Transcriptome analysis revealed that PFOS altered 1054 genes and disrupted crucial signaling pathways such as WNT and TGF-β, which play integral roles in cilia transduction and are critical for early embryonic development. These results provide precise and comprehensive insights into the potential adverse health effects of these six PFAS compounds directly concerning early human embryonic development.

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Section: Discussionsupporting

confidence: 90%

Assessment and Comparison of Early Developmental Toxicity of Six Per- and Polyfluoroalkyl Substances with Human Embryonic Stem Cell Models

Zhao,

Yin,

Yang

et al. 2024

Environ. Sci. Technol.

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“…It is believed that PFAS exposure causes immune suppression, particularly in relation to reduced vaccine response and increased risk of certain infectious diseases or symptoms [ 47 ]. PFAS exposure is also associated with increased risk of cardiovascular diseases [ 48 ], This may be due to the effects of PFAS on blood lipid levels [ 49 ], blood pressure [ 50 ], and atherosclerosis [ 51 ], leading to abnormal functioning of the cardiovascular system. Studies have proposed an association between PFAS exposure and fatty degeneration [ 52 ], as well as a significant positive correlation with liver fibrosis [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Association of per- and polyfluoroalkyl substances with constipation: The National Health and Nutrition Examination Survey (2005–2010)

Zhao,

Pu,

Zheng

et al. 2024

PLoS ONE

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Background The impact of per- and polyfluoroalkyl substances (PFAS) on constipation, as mediated through gastrointestinal absorption and perturbations to the intestinal microecology, remains poorly understood. Objective This study seeks to explain the relationship between PFAS and constipation. Methods A total of 2945 adults from the National Health and Nutrition Examination Survey (NHANES) 2005–2010 were included in this study. Constipation was defined using the Bristol Stool Form Scale (BSFS) based on stool consistency. The relationship between PFAS and constipation was evaluated using weighted logistic regression and restricted cubic spline (RCS) analysis, while adjusting for confounding variables. Results The weighted median concentration of total PFAS (ΣPFAS) was significantly lower in individuals with constipation (19.01 μg/L) compared to those without constipation (23.30 μg/L) (p < 0.0001). Subgroup analysis revealed that the cumulative effect of PFAS was more pronounced in the elderly, men, individuals with obesity, high school education or equivalent, and high-income individuals (p < 0.05). After adjusting for confounding factors, multivariable analysis demonstrated an inverse association between PFOA [OR (95% CI), 0.666(0.486,0.914)] and PFHxS [OR (95% CI), 0.699(0.482,1.015)], and constipation. None of the personal and lifestyle factors showed a significant correlation with this negative association, as confirmed by subgroup analysis and interaction testing (p for interaction > 0.05). The RCS analysis demonstrated a linear inverse relationship between PFAS levels and constipation. Conclusion The findings of this study provide evidence of a significant inverse correlation between serum concentrations of PFAS, particularly PFOA and PFHxS, and constipation.

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“…Thus, if the relationships observed in the present study are causal, the somewhat paradoxical increase in HDL associated with PFAS levels may not have any protective impact on future CVD since PFAS increase the levels of HDL particles not being protective for CVD. So far, mixed results have been reported in the literature regarding PFAS levels and CVD in population-based studies [34][35][36][37][38][39][40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Associations of perfluoroalkyl substances (PFAS) with lipid and lipoprotein profiles

Haug

Dunder

Lind

et al. 2023

J Expo Sci Environ Epidemiol

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Background Perfluoroalkyl substances (PFAS) are man-made chemicals with unique properties that are widely distributed in humans and the environment. Recent studies suggest that PFAS are involved in cholesterol metabolism, however, the mechanisms underlying the associations are poorly understood. Objective We aimed to evaluate associations of plasma PFAS with detailed lipid and lipoprotein subfractions in an adult population of men and women. Methods We measured concentrations of cholesterol and triglycerides in lipoprotein subfractions, apolipoprotein subclasses, as well as fatty acid and different phospholipid measures, using serum proton nuclear magnetic resonance (1H-NMR), and four plasma PFAS using liquid chromatography-mass spectrometry (UHPLC-MS/MS). Measurements were available for 493 participants (all aged 50 years, 50% female). Multivariable linear regression was used to estimate the association of four PFAS with 43 different 1H-NMR measures, with adjustment for body mass index (BMI), smoking, education, and physical activity. Results We found that perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorodecanoic acid (PFDA), but not perfluorohexanesulfonate (PFHxS), concentrations were consistently positively associated with concentrations of cholesterol in lipoprotein subfractions, apolipoproteins, as well as composite fatty acid- and phospholipid profiles. The most consistent associations were found for the relationship of PFAS with total cholesterol in intermediate-density lipoprotein (IDL), across all low-density lipoprotein (LDL) subfractions and small high-density lipoprotein (HDL). Moreover, we found weak to null evidence for an association of any of the measured 13 triglyceride lipoprotein subfractions with PFAS. Conclusions Our results suggest that plasma PFAS concentrations are associated with cholesterol in small HDL, IDL and all LDL subfractions, as well as apolipoproteins and composite fatty acid and phospholipid profiles but to a lesser extent with triglycerides in lipoproteins. Our findings draw attention to the need for more detailed measurements of lipids across various lipoprotein subfractions and subclasses in assessing the role of PFAS in lipid metabolism. Impact By performing an in-depth characterization of circulating cholesterol and triglycerides in lipoprotein subfractions, apolipoprotein, fatty acid, and phospholipid concentrations, this study has expanded upon the limited literature available on the associations of plasma PFAS concentrations beyond clinical routine laboratory testing for lipids.

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Association of increased risk of cardiovascular diseases with higher levels of perfluoroalkylated substances in the serum of adults

Cited by 23 publications

References 71 publications

Assessment and Comparison of Early Developmental Toxicity of Six Per- and Polyfluoroalkyl Substances with Human Embryonic Stem Cell Models

Assessment and Comparison of Early Developmental Toxicity of Six Per- and Polyfluoroalkyl Substances with Human Embryonic Stem Cell Models

Association of per- and polyfluoroalkyl substances with constipation: The National Health and Nutrition Examination Survey (2005–2010)

Associations of perfluoroalkyl substances (PFAS) with lipid and lipoprotein profiles

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