Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum α 2 -HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count

Molvarec, Attila; Prohászka, Zoltán; Nagy, Béla; Kopper, László; Szalay, J; Füst, G.; Karádi, István; Rigó, János

doi:10.1016/j.jri.2006.07.002

Cited by 52 publications

(49 citation statements)

References 35 publications

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“…On the contrary, there was no relationship between serum Hsp70 levels and markers of inflammation in any of the patients groups. These observations on the relationship between hepatopathy and increased sHsp70 levels are in concordance with our previous results (Molvarec et al 2007;Madách et al, submitted) and with the group of Febbraio (Febbraio et al 2002). In these studies, serum sHsp70 levels were found to strongly correlate with laboratory markers of tissue injury in HELLP syndrome and after strong exercise, but not with inflammatory markers.…”

Section: Discussionsupporting

confidence: 92%

“…It has been recognised that Hsp70 are present in the peripheral circulation of healthy individuals (Pockley et al 1998;Dhingra et al 2006), and their levels increase after intensive exercise (Febbraio et al 2002;Fehrenbach et al 2005). Elevation of serum Hsp70 was reported in patients with soft tissue trauma (Pittet et al 2002;Flohe et al 2007), with peripheral and renal vascular disease (Wright et al 2000), after acute myocardial infarction (AMI; Dybdahl et al 2005;Satoh et al 2006), or coronary artery bypass grafting (Dybdahl et al 2002), preeclampsia (Molvarec et al 2006) and haemolytic anemia elevated liver enzymes low platelet count (HELLP) syndrome (Molvarec et al 2007). Genth-Zotz et al (2004) found elevated serum Hsp70 levels in CHF patients and a correlation between the Hsp70 and disease severity and cachexia, but not with survival.…”

Section: Introductionmentioning

confidence: 99%

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Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Gombos

Förhécz

Pozsonyi

et al. 2008

Cell Stress and Chaperones

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Background Circulating heat shock protein 70 (Hsp70) is present in the circulation of healthy individuals and in patients with various disorders, including chronic heart failure (CHF). However, the source and routes of release of Hsp70 is only partially characterised in clinical samples. Aims The purpose of this study was to study the clinical and biological correlates of Hsp70 in a CHF population and, for the first time, to investigate the association of HspA1B (also known as Hsp70-2) +1267 alleles with serum Hsp70 levels. Methods A total of 167 patients (123 men, 44 women) with <45% left ventricular ejection fraction (LVEF) were enrolled; serum Hsp70 level was determined by enzymelinked immunosorbent assay and HspA1B +1267 polymorphism by polymerase chain reaction-restriction fragment length polymorphism.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Gombos

Förhécz

Pozsonyi

et al. 2008

Cell Stress and Chaperones

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“…Several genetic, behavioural and environmental factors need to interact to produce the complete picture of this pregnancyspecific disorder. Our research group reported various genetic and soluble factors that were associated with the severity or complications of preeclampsia (Molvarec et al 2007, Molvarec et al 2008, Molvarec et al 2009b, Rosta et al 2009). …”

Section: Discussionmentioning

confidence: 87%

Increased circulating interleukin-17 levels in preeclampsia

Molvarec

Czegle

Szijártó³

et al. 2015

Journal of Reproductive Immunology

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Increasing evidence suggests that an exaggerated maternal systemic inflammatory response, as well as an angiogenic imbalance plays a central role in the pathogenesis of preeclampsia. In this study, we determined circulating levels of interleukin-17 (IL-17) along with those of angiogenic factors in healthy non-pregnant and pregnant women and preeclamptic patients, and examined whether serum IL-17 levels of preeclamptic patients were related to their clinical features and angiogenic factor concentrations. Fifty-nine preeclamptic patients, 60healthy pregnant women and 56 healthy non-pregnant women were involved in this casecontrol study. Serum levels of IL-17A were measured by high sensitivity ELISA. Serum total soluble fms-like tyrosine kinase-1 (sFlt-1) and biologically active placental growth factor (PlGF) levels were determined by electrochemiluminescence immunoassay. For statistical analyses, non-parametric methods were applied. Serum IL-17 levels were significantly higher in preeclamptic patients than in healthy non-pregnant and pregnant women. We did not find any relationship between serum IL-17 concentrations of preeclamptic patients and their clinical features and serum sFlt-1 and PlGF levels or sFlt-1/PlGF ratios. However, elevated serum IL-17 level and sFlt-1/PlGF ratio was found to be additive for the risk of preeclampsia, as shown by the substantially higher odds ratios of their combination than of either alone. In conclusion, serum IL-17 levels are increased in preeclampsia, which might contribute to the development of the excessive systemic inflammatory response characteristic of the maternal syndrome of the disease. In addition, elevated serum IL-17 level and sFlt-1/PlGF ratio had an additive (joint) effect in the risk of preeclampsia.

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“…When HSPs are released into the extracellular compartment, they are able to deliver a partial maturation signal to dendritic cells, which may play a crucial role in pathogenesis of asthma and activate the NF-kappaB pathway, and can also stimulate pro-inflammatory cytokines production in vitro (Asea et al 2000;Basu et al 2000). This suggests that HSP70 may modulate and exert immune and inflammatory responses and may be involved in the pathogenesis and/or be markers of some diseases like atherosclerosis, ischemia-reperfusion injury, preeclampsia, and HELLP syndrome (Bielecka-Dabrowa et al 2009;Molvarec et al 2007Molvarec et al , 2009Molvarec et al , 2010Walsh et al 2009). Meanwhile, it has been found that extracellular HSP70 level is increased in patients with sarcoidosis and chronic beryllium disease (Silva et al 2007) and COPD patients (Hacker et al 2009).…”

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confidence: 99%

Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients

Hou

Zhao

et al. 2011

Cell Stress and Chaperones

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Damage-associated molecular pattern molecules such as high-mobility group box 1 protein (HMGB1) and heat shock protein 70 (HSP70) have been implicated in the pathogenesis of asthma. The aim of our study was to examine the induced sputum and plasma concentrations of HSP70 in asthmatic patients to determine their relationship with airway obstruction. Thirty-four healthy controls and 56 patients with persistent bronchial asthma matched for gender and age were enrolled in this study. Spirometry measurements were performed before sputum induction. HSP70 levels in induced sputum and plasma were measured using the ELISA Kit. Sputum and plasma concentrations of HSP70 in asthmatics patients were significantly higher than that in control subjects (sputum, (0.88 ng/ml (0.27-1.88 ng/ml) versus 0.42 ng/ml (0.18-0.85 ng/ml), p < 0.001); plasma, (0.46 ng/ml (0.20-0.98 ng/ml) versus 0.14 ng/ml (0.11-0.37 ng/ml), p<0.001) and were significantly negatively correlated with forced expiratory volume in 1 s (FEV1), FEV1 (percent predicted), and FEV1/FVC in all 90 participants and 56 patients with asthma. There were no significant differences in HSP70 levels between patients with eosinophilic and noneosinophilic asthma. HSP70 levels in plasma were positively correlated with neutrophil count, and HSP70 levels in induced sputum were positively correlated with lymphocyte count. In multivariate analysis, independent predictors of sputum HSP70 were diseases and disease severity but not smoking, age, or gender, and independent predictors of plasma HSP70 were also diseases and disease severity. In conclusion, this study indicates that induced sputum and plasma HSP70 could serve as a useful marker for assessing the degree of airway obstruction in patients with asthma. However, further investigation is needed to establish the role of circulating and sputum HSP70 in the pathogenesis of asthma.

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Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum α 2 -HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count

Cited by 52 publications

References 35 publications

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Increased circulating interleukin-17 levels in preeclampsia

Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients

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