Association of induced abortion with bipolar disorder and major depression from the UK Biobank: A Propensity Score Matching and Weighting Analysis

Abstract

Background:Female induced abortion is associated with anxiety and depression, However, fewer studies have focused on the association between induced abortion and bipolar disorder and major depression (BDMD). Objectives: This study aimed to investigate the association between IA and BDMD, and the possible dose-response relationship between them. Methods: We conducted a cross-sectional study of 13,200 female UK Biobank participants. Self-reported number of IAs was categorized into two groups: Non-IA and IA, Moreover, we also explored the number of IA episodes. Covariates adjustment, propensity scores matching (PSM), and inverse probability of treatment weighting (IPTW) were conducted to correct and minimize bias. Results: The IPTW-multivariate logistic regression revealed the OR was 1.25(95%CI:1.19-1.32) and the PSM-multivariate logistic regression revealed the OR was 1.25(95%CI:1.10-1.41) in the IA group, The different number of IAs were also correlated with BDMD,p for trend was <0.05. There was a nonlinear relationship between the number of IAs and the risk of BDMD according to the three-knots restricted cubic spline regression model. Similar conclusions were obtained from the sensitivity analysis. Conclusion:IA was an independent factor for BDMD, Care for mental health care for women after spontaneous abortion is crucial.