Association of Inflammatory Markers with COVID-19 Outcome among Hospitalized Patients: Experience from a Tertiary Healthcare Center in Western India

Sakthivadivel, Varatharajan; Bohra, Gopal Krishana; Maithilikarpagaselvi, Nachimuthu; Khichar, Satyendra; Meena, Mahadev; Palanisamy, Naveenraj; Gaur, Archana; Garg, Mahendra Kumar

doi:10.26574/maedica.2021.16.4.620

Cited by 12 publications

(7 citation statements)

References 24 publications

(23 reference statements)

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“…Furthermore, IL-6 has the greatest sensitivity in predicting mortality among COVID-19 patients. Our results are in accordance with those of Sakthivadivel et al (2021) [6], and demonstrate the potency of IL-6 as a predictor for disease severity and mortality in patients with COVID-19.…”

Section: Discussionsupporting

confidence: 93%

“…Males predominate as patients with COVID-19, and are therefore associated with a more severe form of the disease, similar to the study by Sakthivadivel et al (2021) [6]. The proportion of middle-aged patients with co-morbidities was significantly higher among non-survivors in comparison with survivors [13,14].…”

Section: Discussionsupporting

confidence: 77%

“…Due to the critical role of inflammation and proinflammatory cytokines in the patho-genesis and progression of COVID-19, many authors have investigated the role of inflammatory markers in predicting the severity of COVID-19 as well as the disease outcomes [3][4][5]. The conclusions of these studies that analyze the association of the inflammatory markers with the severity of COVID-19 are inconsistent [6].…”

Section: Introductionmentioning

confidence: 99%

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Association of Inflammatory Markers with Disease Severity and Outcome in Covid-19 Patients

Gjuzelova¹,

Nakova

Nanovic

et al. 2023

Prilozi

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Objectives: The coronavirus pandemic was associated with a high mortality rate in the Republic of North Macedonia. Finding early markers of the disease’s severity may predict outcomes and guide the treatment of the disease. The aim of our study was to evaluate the role of inflammatory markers in predicting the outcome of COVID-19 in hospitalized patients. Methods: The study included 104 PCR-confirmed COVID-19 patients who underwent hospital treatment at the Institute of Lung Diseases and Tuberculosis in Skopje, North Macedonia, between November 2020 and May 2021. Inflammatory markers were assessed in all patients and correlated with the disease severity and outcome in terms of survival or death. Results: IL-6 and LDH at admission were significantly elevated in patients with a severe or critical form of the disease and among non-survivors. In addition, IL-6 showed 87.9% of sensitivity and 61.8% of specificity for distinguishing non-survivors from survivors with a cut-off value of 21.7 pg/ml in the receiver operator curve (ROC). Procalcitonin was significantly increased in non-survivors. Parallel to the increase of disease severity, the values of CRP and LDH increased significantly during hospitalization. Conclusion: The results of the study indicate that a significant association exists between the highly increased levels of CRP, LDH, IL-6 and procalcitonin and the severity of the disease and mortality in COVID-19 patients. Their measurements and follow-up during the course of the disease could be used as predictors for prognosis and outcome but also as a subject for targeted therapy.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Association of Inflammatory Markers with Disease Severity and Outcome in Covid-19 Patients

Gjuzelova¹,

Nakova

Nanovic

et al. 2023

Prilozi

View full text Add to dashboard Cite

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“…The non-survivors were significantly older (61.77 ± 13.89 years) than the survivors (49.91 ± 15.10 years). This is consistent with the previous studies documenting the age-related increase in COVID-19 mortality [4,5]. This could be attributed to natural immunity steadily weakening with age, making older persons more prone to developing more severe illnesses [6].…”

Section: Discussionsupporting

confidence: 93%

“…Identifying crucial laboratory indicators for disease severity at an early stage might assist in monitoring and preventing disease development towards a severe form in the lack of a targeted medication for the illness. Studies have shown that many laboratory indicators, including the total leucocyte count, C-reactive protein (CRP), urea, creatinine, interleukin-6 (IL-6), platelet count, D-dimer, ferritin, random blood sugar levels, and CT-severity score are connected to illness prognosis and outcome [3,4]. The current study was carried out to determine the association of clinical and inflammatory profiles with the outcome of COVID-19 infection.…”

Section: Introductionmentioning

confidence: 98%

Clinical and Inflammatory Profile of COVID-19 Infection at a Tertiary Care Centre in Northern Part of Tamil Nadu – A Retrospective Study

Shanmukham¹,

Srivijayan²,

Venugopal³

et al. 2022

Cureus

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The coronavirus disease (COVID-19) pandemic has incurred high costs for the entire planet. The complex interactions between the host, virus, and environment have resulted in various clinical outcomes. It is crucial to comprehend sickness severity and outcome predictors to provide early preventative measures for a better outcome. The current study aimed to determine the association of clinical and inflammatory profiles with the outcome of COVID-19 infection in patients admitted to the intensive care unit. MethodsThis retrospective study was done in patients admitted to intensive care units for COVID-19 with a positive reverse transcriptase polymerase chain reaction (RTPCR) assay. A total of 125 patients above 18 years were included in the study. The patient's age, gender, and co-morbidities like type 2 diabetes mellitus, hypertension, respiratory illness, and coronary artery disease were noted. The patient's symptomatology, vital signs, oxygen saturation (Spo2), need for inotropes, and non-invasive positive pressure ventilator support (NIPPV) were observed. Computed tomography severity score (CTSS) and hematological and inflammatory parameters at the time of admission were noticed. Patient's management and treatment outcomes as survivors and non-survivors were noted. ResultsThe mean age was significantly greater in non-survivors. The common symptoms were fever, respiratory distress, cough, muscle pain, and sore throat. The leucocyte count, C-reactive protein (CRP), urea, creatinine, interleukin-6 (IL-6), and lactate dehydrogenase (LDH) were greater, and platelet counts were lower significantly in the non-survivors group. On multivariable logistic regression, CT severity score, NIPPV, and IL-6 had an odds ratio of 1.17, 0.052, and 1.03, respectively. IL-6 had a sensitivity of 81.5% and a specificity of 81.8% with a cut-off value of 37.5. ConclusionVigilant monitoring of leucocyte count, CRP, urea, creatinine, IL-6, LDH, platelet count, and CT severity score is essential for managing COVID-19 infection. IL-6 was found to be a significant marker as a predictor of outcome in our study.

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Clinical presentation, ICU management and outcome in severe COVID-19 disease – A prospective observational study

Prakash¹

2023

Ann Antivir Antiretrovir

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Aim: We conducted a prospective, observational study to describe the clinical characteristics, management, and outcomes of patients with moderate to severe coronavirus disease admitted to the Intensive Care Unit (ICU). Methods: The study was conducted from 1st July 2020 to 31st December 2020. The criteria for ICU admission included a positive Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) for the novel Coronavirus (SARS-CoV-2) and oxygen saturation of less than 90% with or without oxygen. Results: A total of 621 patients were included (median age, 59 years [interquartile range {IQR}, 48-68]; 75.8% were males. The common comorbidities were hypertension (323 [52%]), and diabetes mellitus. 96 (15.5%) patients underwent mechanical ventilation, 18 (2.9%) received renal replacement therapy, and 223 (36%) died. The median age in non-survivors was significantly higher [63 years (IQR 55-71)] vs. 57 years (IQR 46-66)] (p < 0.001). Hypoxia (oxygen saturation (SpO2 < 90%) and shortness of breath suggestive of impending respiratory failure were the most common symptoms necessitating ICU admission. A low absolute lymphocyte count (ALC), and high levels of inflammatory biomarkers which persisted for seven days after diagnosis were significantly associated with non-survival. Multivariate logistic regression analysis showed shortness of breath (SOB), hypoxia (SpO2 < 90% on oxygen), use of neuromuscular blockers, and chronic kidney disease as independent risk factors associated with mortality as were the severity scores (APACHE and SOFA). Conclusion: This single-center case series provides clinical characteristics and outcomes of patients with confirmed COVID-19 disease admitted to the COVID ICU. These findings are important for guiding research and preparing for future pandemics.

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Association of Inflammatory Markers with COVID-19 Outcome among Hospitalized Patients: Experience from a Tertiary Healthcare Center in Western India

Cited by 12 publications

References 24 publications

Association of Inflammatory Markers with Disease Severity and Outcome in Covid-19 Patients

Association of Inflammatory Markers with Disease Severity and Outcome in Covid-19 Patients

Clinical and Inflammatory Profile of COVID-19 Infection at a Tertiary Care Centre in Northern Part of Tamil Nadu – A Retrospective Study

Clinical presentation, ICU management and outcome in severe COVID-19 disease – A prospective observational study

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