Association of insulin-like growth factor (IGF)-1 gene polymorphisms with plasma levels of IGF-1 and acne severity

Rahaman, Shekh Mohammad Amanur; De, Dipankar; Handa, Sanjeev; Pal, Arnab; Sachdeva, Naresh; Ghosh, Tulikalipi; Kamboj, Parul

doi:10.1016/j.jaad.2016.05.019

Cited by 52 publications

(56 citation statements)

References 14 publications

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“…Industrial cow's milk has been reported to be spiked with anabolic steroids and other growth factors, such as progesterone, a testosterone precursor . Testosterone precursors and 5α‐reduced molecules are thought to contribute to the comedogenicity of milk by stimulating sebum production and hyperkeratinization of the pilosebaceous unit …”

Section: Resultsmentioning

confidence: 99%

“…Industrial cow's milk has been reported to be spiked with anabolic steroids and other growth factors, such as progesterone, a testosterone precursor. [40][41][42] Testosterone precursors and 5a-reduced molecules are thought to contribute to the comedogenicity of milk by stimulating sebum production and hyperkeratinization of the pilosebaceous unit. 37,40,43 Commonly, cow's milk is available at different fat levels: whole milk, containing about 3.5% of fat; reduced-fat milk, containing about 2% of fat; and fat-free or skimmed milk.…”

Section: Nutrition Factors Potentially Impacting On Acnementioning

confidence: 99%

See 1 more Smart Citation

Acne and nutrition: hypotheses, myths and facts

Claudel¹,

Auffret²,

Leccia

et al. 2018

Acad Dermatol Venereol

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Acne is an inflammatory and multifactorial skin disease. Different external and internal factors, including air pollution, aggressive skincare products, medication, mechanical, hormonal and familial factors and, more recently, lifestyle and stress, have been suggested as having an impact on acne. Moreover, for many years nutrition was believed to cause or worsen acne. Over the last decades, however, it has become a dermatological doctrine that there is no direct association between diet and acne. Even if recent research has allowed to identify certain nutritional elements and behaviour that may impact on acne, including the excessive intake of dairy products and hyperglycaemic food, modern lifestyle nutrition, obesity and eating disorders, knowledge about the role of nutrition in the physiopathology of acne still remains sparse and hypotheses and myths continue to dominate the debate. Thus, further clinical and translational research is necessary to investigate and confirm the association between nutrition and acne.

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Section: Resultsmentioning

confidence: 99%

Section: Nutrition Factors Potentially Impacting On Acnementioning

confidence: 99%

Acne and nutrition: hypotheses, myths and facts

Claudel¹,

Auffret²,

Leccia

et al. 2018

Acad Dermatol Venereol

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“…In sebocytes, IGF-1 -along with androgens -stimulates proliferation and lipogenesis. Serum IGF-1 levels correlate positively with facial sebum secretion in male acne patients [ 19 ] and are higher in acne patients compared to control subjects [ 20,21 ] . Insulin-like growth factor 1 inhibits the transcription factor FoxO1 [ 22 ] .…”

Section: Pathogenesismentioning

confidence: 90%

Acne

Degitz

Ochsendorf

2017

J Deutsche Derma Gesell

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Summary Acne is a chronic disease with a high prevalence among adolescents. Key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). The disease is modulated by a variety of endogenous (androgens, IGF‐1, neuroendocrine factors) and exogenous (Propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. Acne is associated with high morbidity, and even mild manifestations may potentially cause considerable impairment in quality of life. Effective topical and systemic treatments are available. Optimal therapeutic results require continuous patient management over the course of the entire treatment period as well as adjustment of treatment modalities based on symptoms and disease severity.

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“…186,187 Furthermore, polymorphisms within the promoter region of IGF1 are associated with a fourfold increase in the likelihood of developing acne, which may be related to alterations in IGF1 expression. 188,189 Conversely, individuals with congenital IGF1 deficiency do not develop acne. 190 In vitro, IGF1 stimulates lipid synthesis in SZ95 and SEB-1 sebocytes.…”

Section: Erbb Family Receptor Signallingmentioning

confidence: 99%

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

et al. 2019

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Summary Background Sebaceous glands (SGs) are appendages of mammalian skin that produce a mixture of lipids known as sebum. Acne vulgaris is an exceptionally common skin condition, characterized by elevated sebum production, altered sebum composition, and the formation of infundibular cysts, called comedones. Comedo‐associated SGs are atrophic, suggesting that comedo formation involves abnormal differentiation of progenitor cells that generate the SG and infundibulum: the ‘comedo switch’. Understanding the biological processes that govern SG homeostasis promises to highlight potential aetiological mechanisms underlying acne and other SG‐associated skin disorders. Results In this review, we discuss the clinical data, genetic mouse models and in vitro research that have highlighted major hormones, paracrine factors, transcription factors and signalling pathways that control SG homeostasis. These include, but are not limited to androgens, progestogens and oestrogens; retinoids; receptor tyrosine kinases such as ErbB family receptors, fibroblast growth factor receptor 2 and insulin/insulin‐like growth factor 1 receptors; peroxisome proliferator‐activated receptor γ; aryl hydrocarbon receptor; and the Wnt signalling pathway. Where possible, the cellular and molecular mechanisms by which these regulatory factors control SG biology are indicated, along with considerations as to how they might contribute to acne pathogenesis. Conclusions Future research should seek to establish the relative importance, and causative relationships, of altered sebum production, sebum composition, inflammation and abnormal differentiation of sebaceous progenitors to the process of comedo formation in acne. Such an understanding will allow for therapeutic targeting of regulatory factors that control SG homeostasis, with the aim of treating acne.

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Association of insulin-like growth factor (IGF)-1 gene polymorphisms with plasma levels of IGF-1 and acne severity

Cited by 52 publications

References 14 publications

Acne and nutrition: hypotheses, myths and facts

Acne and nutrition: hypotheses, myths and facts

Acne

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

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