Association of Insulin Resistance and β-cell Function With Bone Turnover Biomarkers in Dysglycemia Patients

Guo, Hui; Wang, Chiyu; Jiang, Boren; Ge, Shaohong; Cai, Jian Ping; Zhou, Ying; Rong, Ying; Zha, Kexi; Zhou, Jianyu; Wang, Ningjian; Zhu, Chunfang; Cao, Chenyu; Zhang, Liqin; Gu, Tao; Zhao, Yan; Lu, Yingli; An, Zengmei

doi:10.3389/fendo.2021.554604

Cited by 24 publications

(25 citation statements)

References 40 publications

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“…HOMA-IR was negatively related to P1NP. They conclude that detection of bone turnover markers in diabetes or hyperglycemia patients helps to predict the risk of osteoporosis and fracture, relieve patients' pain and reduce the expenses of long-term cure (36).…”

Section: Discussionmentioning

confidence: 99%

Reduced Serum Levels of Bone Formation Marker P1NP in Psoriasis

Mentzel¹,

Kynast²,

Kohlmann³

et al. 2021

Front. Med.

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Psoriasis is a chronic inflammatory disease of the skin and joints. More recent data emphasize an association with dysregulated glucose and fatty acid metabolism, obesity, elevated blood pressure and cardiac disease, summarized as metabolic syndrome. TNF-α and IL-17, central players in the pathogenesis of psoriasis, are known to impair bone formation. Therefore, the relation between psoriasis and bone metabolism parameters was investigated. Two serum markers of either bone formation—N-terminal propeptide of type I procollagen (P1NP) or bone resorption—C-terminal telopeptide of type I collagen (CTX-I)—were analyzed in a cohort of patients with psoriasis vulgaris. In patients with psoriasis, P1NP serum levels were reduced compared to gender-, age-, and body mass index-matched healthy controls. CTX-I levels were indistinguishable between patients with psoriasis and controls. Consistently, induction of psoriasis-like skin inflammation in mice decreases bone volume and activity of osteoblasts. Moreover, efficient anti-psoriatic treatment improved psoriasis severity, but did not reverse decreased P1NP level suggesting that independent of efficient skin treatment psoriasis did affect bone metabolism and might favor the development of osteoporosis. Taken together, evidence is provided that bone metabolism might be affected by psoriatic inflammation, which may have consequences for future patient counseling and disease monitoring.

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Section: Discussionmentioning

confidence: 99%

Reduced Serum Levels of Bone Formation Marker P1NP in Psoriasis

Mentzel¹,

Kynast²,

Kohlmann³

et al. 2021

Front. Med.

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“…In a study enrolling 5,277 patients with T2D, Guo et al. determined that β-cell function (as measured based on HOMA-%β) was positively correlated with BTM levels ( 29 ). Here, serum sodium levels were found to be independently related to BTMs even following adjustment for glycemic control.…”

Section: Discussionmentioning

confidence: 99%

The association between normal serum sodium levels and bone turnover in patients with type 2 diabetes

Huang

Huang²,

Hua³

et al. 2022

Front. Endocrinol.

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BackgroundSodium is a critically important component of bones, and hyponatremia has firmly been established as a risk factor associated with the incidence of fragility fractures. However, researches have also revealed that lower serum sodium are linked to reductions in muscle mass and a higher risk of cardiovascular disease even when these levels are within the normal range. Accordingly, this study was developed to examine the relationships between normal serum sodium concentrations and bone turnover in patients with type 2 diabetes (T2D).MethodsPatients with T2D were enrolled in the present study from January 2021 to April 2022. All patients underwent analyses of serum sodium levels, oral glucose tolerance testing (OGTT), bone turnover markers (BTMs), and dual-energy X-ray absorptiometry (DXA) scanning. BTMs included bone formation markers osteocalcin (OC) and N-terminal propeptide of type-I procollagen (PINP), and bone resorption marker C-terminal telopeptide (CTx). Patients were stratified into three subgroups based on the tertiles of their serum sodium concentrations.ResultsIn total, 372 patients with T2D and sodium levels in the normal range were enrolled in this study. Serum OC and PINP levels were increased from subgroup with the low sodium tertile to that with the high sodium tertile (p for trend < 0.05), whereas CTx level was comparable among the subgroups. A positive correlation was detected between serum sodium levels and both lnOC (r = 0.210, p < 0.001) and lnPINP (r = 0.196, p < 0.001), with these relationships remaining significant even following adjustment for age, sex, body mass index (BMI), and HbA1c. Only after adjusting for these four factors a positive correlation was detected between serum sodium levels and CTx levels (r = 0.108, p < 0.05). Linear regression analyses revealed that following adjustment for potential covariates, serum sodium level was and positively significantly associated with lnOC level (β = 0.134, t = 2.281, p < 0.05) and PINP level (β = 0.179, t = 3.023, p < 0.01).ConclusionThese results highlight a significant association between low-normal serum sodium levels and low bone turnover.

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“… 40 Guo et al found that PINP and β-CTX levels were negatively correlated with the homeostasis model assessment of insulin resistance (HOMA-IR). 41 Hyperinsulinemia can itself trigger IR, leading to a vicious cycle of hyperinsulinemia-IR, affecting osteoclasts and osteoblasts via dysfunction of the insulin-signaling cascade. 42 , 43 High insulin levels may increase osteoclast activity, which may affect the balance of bone metabolism and thus increase the risk of fracture in patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Bone Turnover Markers with Serum Uric Acid-to-Creatinine Ratio in Men and Postmenopausal Women with Type 2 Diabetes

Xing¹,

Liu²,

Liu³

et al. 2022

DMSO

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Purpose Accumulating evidence has shown that serum uric acid (UA) is associated with some chronic diseases owing to its antioxidant capacity; however, previous research has discrepant results regarding the relationship between UA and bone health. UA normalized by renal function can reflect endogenous UA levels more precisely than SUA levels. This study assessed the relationship between serum UA-to-creatinine (SUA/Cr) ratio and bone turnover markers (BTMs) in men and postmenopausal women with type 2 diabetes mellitus (T2DM). Patients and Methods Overall, 1691 patients (1028 males and 663 postmenopausal females) with T2DM admitted to Hebei General Hospital between January and December 2020 were selected and divided into two groups according to their SUA/Cr ratio. One-way analysis of variance was used to compare groups. The relationship between the SUA/Cr ratio and BTMs (including osteocalcin [OC], procollagen I N-terminal peptide [PINP], and β-isomerized type I collagen C-telopeptide breakdown products [β-CTX]) was analyzed using multiple linear regression. Furthermore, subgroup analyses were performed to explore the differences between men and women in the relationship between SUA/Cr and BTMs. Mediation analysis was used to explore whether insulin resistance mediated the association between SUA/Cr and BTMs. Results β-CTX and PNIP levels of patients with T2DM in the low SUA/Cr group were significantly higher than those in the high SUA/Cr group, and the difference between the two groups was statistically significant (P < 0.05). Correlation analysis showed that SUA/Cr was negatively correlated with β-CTX and PNIP. After adjusting for confounding factors, multivariate linear regression analysis revealed that the SUA/Cr level was negatively correlated with PINP and β-CTX in male patients and postmenopausal women with T2DM. Stronger correlations were found in patients with 25(OH)D3 < 20ng/mL, course ≥ 5 years, HbA1c > 7%, or BMI < 28 kg/m2. Conclusion SUA/Cr ratio was an independent influencing factor of BTMs in patients with T2DM.

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Association of Insulin Resistance and β-cell Function With Bone Turnover Biomarkers in Dysglycemia Patients

Cited by 24 publications

References 40 publications

Reduced Serum Levels of Bone Formation Marker P1NP in Psoriasis

Reduced Serum Levels of Bone Formation Marker P1NP in Psoriasis

The association between normal serum sodium levels and bone turnover in patients with type 2 diabetes

Relationship of Bone Turnover Markers with Serum Uric Acid-to-Creatinine Ratio in Men and Postmenopausal Women with Type 2 Diabetes

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