Association of Insulin Resistance with Serum Interleukin-6 and TNF-α Levels during Normal Pregnancy

Abstract

Overview:The purpose of this study was to evaluate the role of Tumor Necrosis Factor-α (TNF-α) in insulin resistance (IR) during normal pregnancy.Approach:This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively, and in 21 healthy non pregnant women. Serum TNF-α concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method.Results:There were significant differences between serum TNF-α and IL-6 levels in pregnant women as compared with maternal healthy controls. There was significant correlation between gestational age and Body Mass Index (BMI) (r = 0.28, P = 0.01). There was no significant correlation between gestational age and insulin resistance (IR). We also did not find correlations between IR and TNF-α and IR and IL-6 in pregnant women.Conclusion:In conclusion, our findings suggest that TNF-α and IL-6 are not greatly contributed to pregnancy induced insulin resistance in normal pregnancy.

Insulin Resistance and Serum Levels of Interleukin-17 and Interleukin-18 in Normal Pregnancy

“…These results were in consonance with the data founded by previous researches (11). A common complication during pregnancy is glucose metabolism disorder which its pathology is related to deficiency of insulin secretion and insulin resistance.…”

Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

“…In a recently published study, it has been reported that in normal pregnant women both maternal IL-6 (Jahromi et al, 2011a) and TNF-α cytokines are increased (Zareian et al, 2010;Elsamanoudy and Abbas, 2010) and IL-1β is decreased (Jahromi et al, 2011b), But it was not find any correlation between IR with IL-6 and TNF-α. (Jahromi et al, 2011a) and between IR with IL-1β (Jahromi et al, 2011b). Resistin is an insulin-sensitizing adipokine that can be implicated in endogenous glucose regulation (Mohiti et al, 2009).…”

The Relation Of Oxidative Stress Biomarkers With Proinflammatory Cytokines In Gestational Diabetes

“…There are studies to demonstrate the importance of these cytokines in insulin resistance and GDM [1]. Visfatin is an adipocyte-derived protein, and its secretion is mediated by plasma levels of glucose and insulin.…”

“…Insulin resistance and disturbances in carbohydrate metabolism may develop in pregnancy because of the necessity to supply appropriate nutrients for fetal growth and placental metabolism [1]. GDM has been shown to associate closely with increased synthesis of proinflammatory cytokines, the molecules that is known to involve in developing insulin resistance and GDM [2,3].…”