Association of insulin resistance with anti‐Mullerian hormone levels in women without polycystic ovary syndrome (PCOS)

Park, Hyun T.; Cho, Geum J.; Ahn, Ki Hoon; Shin, Jung Hoon; Kim, Young Tae; Hur, Jun Young; Kim, Sun H.; Lee, Kyu W.; Kim, Tak

doi:10.1111/j.1365-2265.2009.03614.x

Cited by 83 publications

(72 citation statements)

References 42 publications

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“…However, the small number of subjects in this study, differences in study populations and clinical setting must all be taken into consideration. The purported relationship between insulin resistance and metabolic syndrome with AMH has been a source of controversy [26,29]. In our study, AMH was not related to insulin resistance-or metabolic syndrome-related variables, irrespective of the PCOS status, and is in agreement with other studies [8,11].…”

Section: Discussionsupporting

confidence: 82%

Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

et al. 2012

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POLYCYSTIC OVARY SYNDROME (PCOS) is one of the most common endocrinological problems in women. In addition to chronic oligo-anovulation, the main features of the PCOS include elevated levels of circulating androgens and/or clinical hyperandrogenism, polycystic ovary morphology, altered gonadotropin secretion, insulin resistance and/or compensatory hyperinsulinemia often associated with obesity [1]. Women affected by PCOS also show a higher risk of type 2 diabetes, dyslipidemia, hypertension and cardiovascular diseases [2][3][4].Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome Abstract. The aim of the present study was to compare the associations of anti-Müllerian hormone (AMH) with clinical or biochemical characteristics between women with and without polycystic ovary syndrome (PCOS). We also explored the optimal cutoff point of AMH to diagnose PCOS. A cross-sectional study was performed in 87 women diagnosed with PCOS and 53 healthy control subjects. Body mass index (BMI), indices of insulin resistance, metabolic syndrome-related variables, reproductive hormones and serum AMH were measured in all subjects. We conducted receiver operating characteristic (ROC) curve analysis to determine the cutoff of AMH for diagnosis of PCOS. Serum AMH levels were significantly (p <0.001) higher in women with PCOS after adjustment for age and BMI. AMH levels were not significantly related with obesity, indices of insulin resistance, and metabolic syndrome-related variables in both PCOS and control groups. In the control group, AMH levels showed positive correlations with total testosterone (p <0.001), free testosterone (p=0.024), and adiponectin (p=0.002), and showed negative correlations with age (p=0.010) and estradiol (E2) (p=0.012). However, only total (p=0.044) and free testosterone (p=0.012) levels showed significant positive correlations with serum AMH level in PCOS group. ROC curve analysis showed a cutoff point for AMH of 7.82 ng/mL (sensitivity 75.9%, specificity 86.8%) for diagnosis of PCOS. Differences of the association of AMH with clinical or biochemical characteristics between women with PCOS and control groups were observed. This might contribute to the pathogenesis of PCOS, although further investigation is necessary to elucidate the detailed mechanism.

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Section: Discussionsupporting

confidence: 82%

Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

et al. 2012

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“…Therefore, we evaluated fasting insulin levels as a measure for insulin resistance and related these to ovarian reserve markers. The negative association between fasting insulin levels and AMH was previously described in the reproductive-age women without PCOS (16) and was confirmed by our study among CCS.…”

Section: Discussionsupporting

confidence: 72%

“…To our knowledge, no other studies that assess a possible link between obesity and AMH have been performed in female CCS. In the general population, only one study among three has shown an association in women of reproductive age (15,16,32).…”

Section: Discussionmentioning

confidence: 99%

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Decreased ovarian function is associated with obesity in very long-term female survivors of childhood cancer

Dorp

Blijdorp

Laven³

et al. 2013

European Journal of Endocrinology

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Objective: Obesity and gonadal dysfunction are known major side effects of treatment in adult childhood cancer survivors (CCS). In the general population, obesity has a negative influence on female fertility. We aimed to evaluate whether obesity and serum insulin are associated with decreased ovarian reserve markers in CCS. Design: Retrospective single-center cohort study. Methods: Data of 191 female survivors of childhood cancer were analyzed. Median follow-up time was 18.8 (2.3-48.8) years. Outcome measures were serum anti-Mü llerian hormone (AMH) and total follicle count (FC). Potential risk factors were: BMI; body composition measures, determined by dualenergy X-ray absorptiometry (total fat percentage, lean body mass, and visceral fat percentage); and fasting insulin. Results: Lower serum AMH was found in obese subjects (b (%) K49, PZ0.007) and in subjects with fasting insulin in the highest tertile (b (%) K43, PZ0.039). Total fat percentage tends to be associated with serum AMH (b (%) K2.1, PZ0.06). Survivors in the highest tertile of insulin had significantly lower FC than survivors in the lowest tertile (b K6.3, PZ0.013). BMI and other measures of body composition were not associated with FC. Correlation between serum AMH and antral follicle count (AFC) was rZ0.32 (PZ0.08). Conclusions: Obesity and insulin resistance are associated with gonadal damage, as reflected by decreased AMH and reduced FC in adult survivors of childhood cancer. In contrast to its highly predictive value for AFC in the healthy female population, serum AMH does not seem to correlate as well with AFC in CCS.European Journal of Endocrinology 168 905-912

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“…In these studies, the evaluation of the relationship between AMH concentrations and BMI generally showed contradictory results. In some studies [14,15] a significant inverse association between AMH levels and BMI was found, whereas some others [16][17][18][19] found no relationship between AMH and BMI.…”

Section: Introductionmentioning

confidence: 95%

Serum anti‐müllerian hormone concentrations in reproductive age women with and without polycystic ovary syndrome: the influence of body mass index

Şahmay

Güralp

Şentürk

et al. 2011

Reprod Medicine & Biology

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Purpose To evaluate the correlation between anti-mülle-rian hormone (AMH) and body mass index (BMI) in patients with and without polycystic ovarian syndrome (PCOS). Methods Serum AMH levels of 332 women in their reproductive period and below 45 years of age who were admitted to our reproductive endocrinology clinic with infertility were investigated in a cross-sectional study. Patients were divided into two groups as BMI under and equal or over 25 kg/m 2 . Both groups were divided into two subgroups as PCOS and non-PCOS. AMH levels of patients were analyzed for each group. Results Mean AMH values of BMI \25 and C25 kg/m 2 groups were 3.87 ± 2.95 and 3.58 ± 2.93 ng/mL, respectively (P [ 0.05) in all patients. Means of AMH were not significantly different in BMI quartiles (r = -0.008401, P = 0.96). Among 107 patients with PCOS, means of AMH were 6.85 ± 2.95 ng/mL in 56 patients with BMI \25 kg/m 2 and 6.66 ± 3.18 ng/mL in 51 patients with BMI C25 kg/m 2 (P [ 0.05). In the group of 225 non-PCOS patients, means of AMH were 2.27 ± 1.12 ng/mL in 104 patients with BMI\25 kg/m 2 and 2.28 ± 1.49 ng/mL in 121 patients with BMI C25 kg/m 2 (P [ 0.05). Conclusions Body mass index does not seem to have an effect on serum AMH levels in reproductive age women both with and without PCOS.

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Association of insulin resistance with anti‐Mullerian hormone levels in women without polycystic ovary syndrome (PCOS)

Abstract: An independent relationship exists between HOMA-IR and AMH in women without PCOS, possibly due to the effect of abnormal insulin action on AMH secretion by granulosa cells.

Cited by 83 publications

References 42 publications

Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

Decreased ovarian function is associated with obesity in very long-term female survivors of childhood cancer

Serum anti‐müllerian hormone concentrations in reproductive age women with and without polycystic ovary syndrome: the influence of body mass index

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