Association of insulin resistance with different anthropometric measures and cardiovascular risk factors in a non-diabetic population

Rueda, Marta Simarro; Herencia, Julio A. Carbayo; Orozco, Javier Massó; Ródenas, L.; Valero, Lucinio Carrión; Garrote, J.A. Divisón; Moreno, Pilar Torres; Abril, Juan López; Hernández, Abel J. Herrero; Escribano, Francisca Molina

doi:10.1016/j.endoen.2011.06.006

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…IR has long been linked to the ageing process, (53,54), as it is generally linked to an increase in fat mass and body weight, particularly in the centre of the body (55), along with a greater prevalence of chronic lifestyle-associated diseases such as metabolic syndrome (56). Generally, an increased anthropometrical measurement gives a greater risk of IR; (57) with a positive correlation between the waist-to-hip ratio (58) and the BMI (59).…”

Section: Summary Of This Thesis Findingsmentioning

confidence: 99%

Type 2 diabetes and insulin resistance among euglycaemic and diabetic patients with Pulmonary Tuberculosis in Saudi Arabia

Almaleki

2020

مجلة القراءة والمعرفة

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Background: Patients with Tuberculosis (TB) are more likely to have Type 2 Diabetes Mellitus (T2DM). Individuals with insulin resistance (IR) with normal glucose may also be at risk for TB, but there are no data available. Methods:To explore whether T2DM and IR are risk factors for TB we enrolled patients receiving TB treatment in Saudi Arabia and healthy controls to assess the frequency of both conditions in both populations. Controls were adults attending the TB clinics to obtain a screening certificate for labour reasons. All participants were screened for fasting plasma glucose (FPG), insulin, glycated haemoglobin (HbA1c) and lipids. We assessed the severity of the clinical presentation of TB among patients with T2DM, IR and normal glucose.Results: 175 adults with pulmonary TB (cases) and 140 controls were recruited. Fifty-one (29%) of TB cases had T2DM and 27 (22%) normoglycemic IR compared to 39 (27.9%) and 26 (25.7%) of the controls, respectively. Six (3.3%) of cases and 12 (8.6%) of controls were unaware of their T2DM diagnosis. TB was associated with pre-diabetes (AOR 5.112, p = 0.032), low level of risky HDL Cholesterol (AOR 0.316, p = 0.001) and non-Saudi nationality (AOR 4.018, p ˂ 0.001). Cases were more likely to eat fast foods and to have a poor diet than controls (p ˂ 0.001). Conclusion:TB cases were more likely to be of non-Saudi nationality, to be male and to have T2DM and prediabetes, but were not more likely to have IR than controls.

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Section: Summary Of This Thesis Findingsmentioning

confidence: 99%

Type 2 diabetes and insulin resistance among euglycaemic and diabetic patients with Pulmonary Tuberculosis in Saudi Arabia

Almaleki

2020

مجلة القراءة والمعرفة

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Prevalence of Insulin Resistance in Subjects with Nonalcoholic Fatty Liver Disease and Its Predictors in a Chinese Population

Zhang

et al. 2015

Dig Dis Sci

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The association between tuberculosis and the development of insulin resistance in adults with pulmonary tuberculosis in the Western sub-district of the Cape Metropole region, South Africa: a combined cross-sectional, cohort study

et al. 2017

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BackgroundThe existence of a bi-directional relationship between tuberculosis (TB) and insulin resistance (IR)/diabetes has been alluded to in literature. Although diabetes has been linked to increased tuberculosis risk, the relationship between tuberculosis as a causative factor for IR remains unclear. The study aimed to determine if an association existed between tuberculosis and IR development in adults with newly diagnosed pulmonary tuberculosis at baseline. It was additionally aimed to document changes in IR status during TB follow-up periods.MethodsThis cross-sectional study evaluated ambulatory participants at baseline for IR prevalence via anthropometry, biochemistry and diagnostic IR tests [homeostasis model assessment-IR (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)]. A prospective cohort sub-section study was additionally performed on approximately half of the baseline study population, who were followed-up at two and five months whilst on tuberculosis treatment. Summary statistics, correlation co-efficients and appropriate analysis of variance were used to describe and analyse data. Participants were excluded if they presented with other forms of tuberculosis, were HIV-positive, obese or had any pre-disposing IR conditions such as diabetes or metabolic syndrome.ResultsFifty-nine participants were included from August 2013 until December 2014 (33.95 ± 12.02 years old; 81.4% male). IR prevalence was 25.4% at baseline, determined by a calculated HOMA-IR cut-off point of 2.477. Patients with IR were younger (p = 0.04). Although the difference between IR levels in participants between baseline and follow-up was not significant, a decrease was observed over time. The majority of participants (61.0%) presented with a normal BMI at baseline. Mean baseline values of fasting glucose were within normal ranges (4.82 ± 0.80 mmol/L), whereas increased mean CRP levels (60.18 ± 50.92 mg/L) and decreased mean HDL-cholesterol levels (males: 0.94 ± 0.88 mmol/L; females: 1.14 ± 0.88 mmol/L) were found.ConclusionsThe study found an association between tuberculosis and IR development in newly diagnosed pulmonary tuberculosis patients. Although not significant, IR levels decreased over time, which could be indicative of a clinical improvement. A high prevalence of IR amongst young tuberculosis patients therefore highlights the need for early identification in order to facilitate a reversal of IR and prevent possible IR-related complications.

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Association of insulin resistance with different anthropometric measures and cardiovascular risk factors in a non-diabetic population

Cited by 3 publications

References 27 publications

Type 2 diabetes and insulin resistance among euglycaemic and diabetic patients with Pulmonary Tuberculosis in Saudi Arabia

Type 2 diabetes and insulin resistance among euglycaemic and diabetic patients with Pulmonary Tuberculosis in Saudi Arabia

Prevalence of Insulin Resistance in Subjects with Nonalcoholic Fatty Liver Disease and Its Predictors in a Chinese Population

The association between tuberculosis and the development of insulin resistance in adults with pulmonary tuberculosis in the Western sub-district of the Cape Metropole region, South Africa: a combined cross-sectional, cohort study

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