Association of interleukin-1 beta (-511C/T) polymorphisms with osteoporosis in postmenopausal women

Abstract

BACKGROUND AND OBJECTIVES:Osteoporosis is a common disease of the elderly, in which genetic and clinical factors contribute to the disease phenotype. Since the production of interleukin-1 (IL-1) has been implicated in the bone mass and skeletal disorders, we investigated whether IL-1 system gene polymorphisms are associated with the pathogenesis of osteoporosis in postmenopausal Taiwanese women.METHODS:Osteoporosis is diagnosed by dual-energy x-ray absorptiometry, which measures bone mineral density (BMD) at multiple skeletal sites. We studied the IL-1α (-889C/T), IL-1β (-511C/T) and the 86 base pair variable number tandem repeat (VNTR) in intron 2 of the IL-1 receptor antagonist (IL-1ra) gene in 117 postmenopausal women with osteoporosis and 135 control subjects without a history of symptomatic osteoporosis. These gene polymorphisms were analyzed by polymerase chain reaction and restriction fragment length polymerase. Blood sugar and other risk factors were also determined.RESULTS:The frequencies of IL-1β (-511C/T) genotypes (P=.022, odds ratio=1.972) and alleles (P=.02, odds ratio=2.909) showed a statistically significant difference between the two groups. However, we did not find any statistically significant difference in IL-1α and IL-1ra polymorphisms (P>.05). We also observed a positive relationship between osteoporosis and cholesterol and a weak inverse relationship between blood sugar and osteoporosis in postmenopausal women.CONCLUSIONS:These experimental results suggest that the pathogenesis of osteoporosis is associated with IL-1β (-511C/T) polymorphism in postmenopausal women. This polymorphism is an independent risk factor for osteoporosis.

Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-κB signaling pathways in osteoprotegerin knockout mice

“…According to published data, the National Osteoporosis Foundation (NOF) estimates that as many as 54 million Americans have osteoporosis and decreased bone mass (1–3). Studies have shown that approximately half of the female and one quarter of the male population will suffer from bone fractures due to osteoporosis (4,5). More than 50% of non-Hispanic Caucasian and Asian women aged 50 years and older have a decreased bone mass, thus increasing their risk for osteoporosis (6,7).…”

Bone Mineral Density and Proinflamatory Cytokines (IL-1ß and TNFa) in Menopause

“…Recent studies have suggested that IL-1β genic polymorphism plays the role in pathogenesis of osteoporosis in postmenopausal women, which is an independent risk factor for osteoporosis (23). It has also been demonstrated that in postmenopausal osteoporotic women IL-1β, IL-1β/IL-1α ratio and IL-1 bioactivity are elevated, and that they return to premenopausal values only 15 years after menopause (24).…”

Search for genetic markers determining the efficiency of therapy with bisphosphonates in Russian women with postmenopausal osteoporosis: A pilot study

“…Являясь мощным стимулятором костной резорбции in vitro и in vivo, этот провоспалительный цитокин повышает про-дукцию белка RANKL, увеличивает его активность и сти-мулирует остеокластогенез [30]. В ряде исследований на-блюдалась ассоциация полиморфизма гена IL1β с МПК и предрасположенностью к ОП у женщин в постменопа-узе [20,21]. U. Dundar и соавт.…”

“…Поэтому мы решили изучить возможное влияние генетических вариантов ряда генов, участвую-щих в детерминации МПК, на антирезорбтивный эф-фект 12-месячного лечения БФ. Помимо уже изученных полиморфизмов генов VDR и IL1β, в настоящем иссле-довании мы оценивали несколько других генов, ассоци-ированных с МПК, включая ген МСР1, кодирующий моноцитарный хемоаттрактантный белок 1 [15], ген LEPR, кодирующий рецептор лептина [16,17], ген IL10 [18], ген MHTFR, кодирующий метиленгидротетрафо-лат редуктазу [19], ген IL1β [20,21], ген SPP1, кодирую-щий белок остеопонтин [22], ген CCR5, кодирующий ре-цептор хемокина CCR5 [16], ген PPARG, кодирующий рецептор -активатор пролиферации пероксисом типа gamma [23].…”