Association of Interleukin‐1 beta and tumor necrosis factor‐alpha genetic polymorphisms with gastric cancer in India

Sultana, Zareen; Bankura, Biswabandhu; Pattanayak, Arup Kumar; Sengupta, Debmalya; Sengupta, Mainak; Saha, Makhan; Panda, Chinmay Kumar; Das, Madhusudan

doi:10.1002/em.22208

Cited by 18 publications

(11 citation statements)

References 70 publications

(87 reference statements)

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“…It suggested that IL-6 SNPs are very useful prognostic biomarkers in clinical usage and could be truly specific in prognosis of a particular cancer type (18). These results are completely consistent with other investigations (46)(47)(48). IL-1α and IL-1β, two members of IL-1, have a common receptor with shared SNPs (IL-1α-889C>T and IL-1β-3737C>T) (49).…”

Section: Discussionsupporting

confidence: 81%

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Association between interleukin gene polymorphisms and multiple myeloma susceptibility

et al. 2020

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The present study performed a retrospective observational study in order to investigate the relationship between the interleukin family gene polymorphisms and risk of multiple myeloma (MM), based on sixteen case-control studies that contained 2,597 patients with MM and 3,851 controls. The results demonstrated that the genotypes IL-6 and IL-1 GG increased the risk of MM by approximately 40.8 and 80.2% compared with the genotypes AA and CC [odds ratio (OR)=1.14, 95% confidence interval (CI), 0.88-1.47, and OR=1.16, 95% CI, 0.61-2.19; respectively]. The results also revealed a significant association between T:C polymorphism of the IL-6 and IL-10 and the risk of MM (TC/CC: OR=1.37, 95% CI, 0.88-2.16 and TT/CC: OR=1.26, 95% CI, 0.77-2.06, respectively). Additionally, no significant association was identified between the C:A polymorphisms of the IL-6 (rs8192284) and IL-10 (rs1800872) receptors and the overall risk of MM (P>0.05). G:C polymorphisms of the IL-1β1464G>C and IL-6572G>C significantly increased the risk of MM (P<0.05). However, it has been determined that there is a significant association between the C:T polymorphism of the IL-1α-889C>T and IL-1β-3737C>T and the risk of MM (P<0.001). Subgroup analysis revealed that the detection of G:A polymorphisms in the IL-6 promoter (OR=1.05, 95% CI, 0.78-1.44) is more accurate in MM samples of the Asian population (OR=1.24, 95% CI, 0.92-1.74). In addition, no significant association was identified between the IL gene polymorphisms in MM samples categorized by ethnicity and the IL family type (P=0.27). These single nucleotide polymorphism loci may be the appropriate gene markers for gene screening and a promising therapeutic strategy in the prognostics of patients with MM.

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Section: Discussionsupporting

confidence: 81%

“…Recently, Sultana et al, (2018) (48) indicate that the C allele of IL-1α-889 is higher in MM patients than in controls. Similarly, Ziakas et al, (2013) (50) show that the G allele of IL-1β-1464G>C was significantly associated with MM in an Asian population.…”

Section: Discussionmentioning

confidence: 98%

Association between interleukin gene polymorphisms and multiple myeloma susceptibility

et al. 2020

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“…Lastly, intrinsic mutations and polymorphisms in IL-1 genes have been implicated as well in many cancer types as reviewed by Khazim et al [ 79 ], though results from studies are sometimes conflicting, and the association is not always clear. Single and IL-1 gene-cluster polymorphisms have been suggested to be associated with cancers such as cervical [ 80 ] and ovarian cancer [ 81 ], MM [ 82 ], esophageal [ 83 ], colorectal cancer (CRC) [ 84 ], NSCLC [ 85 ], pancreatic cancer [ 86 ], prostate cancer [ 87 ], and gastric cancer [ 88 – 90 ].…”

Section: Il-1 Dysregulation and Its Contribution To Cancer And Tumorimentioning

confidence: 99%

The Role of Interleukin-1 in the Pathogenesis of Cancer and its Potential as a Therapeutic Target in Clinical Practice

2018

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Interleukin-1 (IL-1) has long been known to be a key mediator of immunity and inflammation. Its dysregulation has been implicated in recent years in tumorigenesis and tumor progression, and its upregulation is thought to be associated with many tumors. Overexpression of the IL-1 agonists IL-1a and IL-1b has been shown to promote tumor invasiveness and metastasis by inducing the expression of angiogenic genes and growth factors. IL-1 blockers such as anakinra and canakinumab are already approved and widely used for the treatment of some autoimmune and autoinflammatory diseases and are currently being tested in preclinical and human clinical trials for cancer therapy. In this paper we review the most recent discoveries regarding the association between IL-1 dysregulation and cancer and present the novel IL-1 blockers currently being tested in cancer therapy and their corresponding clinical trials.

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“…Moreover, many associations of TNF_rs1800630 * A with diseases have been reported. Those of enhanced susceptibility to cancer seem to indicate that reduced TNF levels increase the chance of inappropriate cell proliferation, due to insufficient signaling for apoptosis/necroptosis [e.g., hepatocellular carcinoma (43), non-Hodgkin lymphoma (44, 45), gastric cancer (46), and colon cancer (47)]. On the other hand, the same allele was associated with progression to and severity of infections, as for severe malaria, including cerebral malaria (48, 49), HPV-associated oral squamous carcinoma (50), HBV chronification (51), as well as with chronic disorders, which may rely on insufficient immunological response to different kinds of aggressors [steroid-induced osteonecrosis of the femoral head (52), progression of acute pancreatitis to systemic inflammation and multi-organ dysfunction syndrome (53), chronic periodontitis (54), and cardiovascular heart disease (55)].…”

Section: Discussionmentioning

confidence: 99%

Condemned or Not to Die? Gene Polymorphisms Associated With Cell Death in Pemphigus Foliaceus

et al. 2019

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Pemphigus foliaceus (PF) is an autoimmune blistering skin disease that occurs sporadically across the globe and is endemic in Brazil. Keratinocyte adhesion loss (acantholysis) is associated with high levels of anti-desmoglein 1 IgG autoantibodies, but the role of cell death is poorly understood in PF. Current evidence disqualifies apoptosis as the major cell death mechanism and no other process has yet been investigated. To approach the role of variation in genes responsible for cell death pathways in pemphigus susceptibility, we systematically investigated the frequencies of 1,167 polymorphisms from genes encoding products of all 12 well-established cell death cascades (intrinsic and extrinsic apoptosis, necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic, NETotic, lysosome-dependent, autophagy-dependent, and immunogenic). By multivariate logistic regression, we compared allelic and genotypic frequencies of 227 PF patients and 194 controls obtained by microarray hybridization. We found 10 variants associated with PF (p < 0.005), belonging to six cell death pathways: apoptosis (TNF, TRAF2, CD36, and PAK2), immunogenic cell death (EIF2AK3, CD47, and SIRPA), necroptosis (TNF and TRAF2), necrosis (RAPGEF3), parthanatos (HK1), and pyroptosis (PRKN). Five polymorphisms were associated with susceptibility: TNF rs1800630*A (OR = 1.9, p = 0.0003), CD36 rs4112274*T (OR = 2.14, p = 0.0015), CD47 rs12695175*G (OR = 1.77, p = 0.0043), SIRPA rs6075340*A/A (OR = 2.75, p = 0.0009), and HK1 rs7072268*T (OR = 1.48, p = 0.0045). Other five variants were associated with protection: TRAF2 rs10781522*G (OR = 0.64, p = 0.0014), PAK2 rs9325377*A/A (OR = 0.48, p = 0.0023), EIF2AK3 rs10167879*T (OR = 0.48, p = 0.0007), RAPGEF3 rs10747521*A/A (OR = 0.42, p = 0.0040), and PRKN rs9355950*C (OR = 0.57, p = 0.0004). Through functional annotation, we found that all associated alleles, with the exception of PRKN rs9355950*C, were previously associated with differential gene expression levels in healthy individuals (mostly in skin and peripheral blood). Further functional validation of these genetic associations may contribute to the understanding of PF etiology and to the development of new drugs and therapeutic regimens for the disease.

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Association of Interleukin‐1 beta and tumor necrosis factor‐alpha genetic polymorphisms with gastric cancer in India

Cited by 18 publications

References 70 publications

Association between interleukin gene polymorphisms and multiple myeloma susceptibility

Association between interleukin gene polymorphisms and multiple myeloma susceptibility

The Role of Interleukin-1 in the Pathogenesis of Cancer and its Potential as a Therapeutic Target in Clinical Practice

Condemned or Not to Die? Gene Polymorphisms Associated With Cell Death in Pemphigus Foliaceus

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