Association of interleukin-1 receptor antagonist (IL1RN) genetic variants with severity of knee osteoarthritis

Ahmed, Inas A.; Mansour, Amira I.; Elnady, Basant; Basset, Shaza A. Abdul; Fawzy, Iman M.

doi:10.21608/besps.2016.8648

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study by Wu and colleagues in 2012 showed that an IL-1RN gene variant (rs419598/rs9005/rs315943) was associated with increased progression of knee OA 7 . A study by Ahmed in 2016 showed that genetic variants in IL-1RN (rs9005 and rs315943) were associated with the risk of OA development 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Based on a sample size calculation with a power of 80%, β = 0.2 and α = 0.05 using binomial proportions, the sample for the control group was 100 patients, and the sample for the case group was 130 patients, who were divided into grade 2 with mild OA (65 patients) and grades 3–4 with moderate-severe OA (65 patients). We evaluated the clinical findings (using the VAS, EQ-5D-3L, and KOOS), radiological scores (Kellgren-Lawrence), laboratory findings (protein IL-1R1 and IL-1Ra) in plasma, and genetic polymorphisms of IL-1R1 and IL-1RN with 4 SNPs (IL-1R1_rs228704, IL-1RN_rs419598, IL-1RN_rs9005, and IL-1RN_rs315943) based on previous studies performed by Attur et al 10 , Wu et al 7 , and Ahmed et al 8 . To screen other SNPs that might correlate with primary knee OA, we performed next-generation sequencing (NGS).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia

Budhiparama

Lumban-Gaol²,

Sudoyo

et al. 2023

Sci Rep

View full text Add to dashboard Cite

This study aimed to evaluate the association of SNPs of the IL-1 family with the clinical severity of knee OA. This case‒control study was performed among 100 healthy knees and 130 osteoarthritis (OA) knees of people aged ≥ 50 years with a BMI ≥ 25 kg/m2. The possible correlations among clinical findings, radiographic evaluations, serum levels of IL-1R1 and IL-1Ra, and genotype analyses were evaluated. Three SNPs of IL-1R1, rs871659, rs3771202, and rs3917238, were associated with primary knee OA. Females with IL-1R1 SNP rs871659 allele A had a higher prevalence of primary knee OA. No correlation was found between SNPs of IL-1R1 and IL-1RN and clinical or radiologic severity or serum concentrations of IL-1R1 and IL-1Ra (p > 0.05). BMI and IL-1R1 rs3917238 genotype C/C were correlated with moderate-severe VAS scores. A correlation was also found between the EQ-5D-3L self-care dimension and obesity and between the EQ-5D-3L pain and usual activity dimensions and age ≥ 60 and obesity (p < 0.05). Radiologic severity was only associated with age ≥ 60 years (p < 0.05). We found the IL-1R1 SNPs rs871659, rs3771202, and rs3917238 to be predisposing factors for primary knee osteoarthritis. The clinical findings, radiographic severity, and serum concentrations of IL-1R1 and IL-1Ra were not correlated with these gene polymorphisms.

show abstract

Section: Discussionmentioning

confidence: 99%