Association of Interleukin-10 gene promoter polymorphisms with obstructive sleep apnea

Özdaş, Sibel; Özdaş, Talih; Acar, Mustafa; Erbek, Selim S.; Köseoğlu, Sabri; Göktürk, Gökhan; İzbırak, Afife

doi:10.1007/s11325-015-1216-9

Cited by 8 publications

(5 citation statements)

References 35 publications

(46 reference statements)

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“…In this study, DNA sequence analysis of the IL-10 gene's promoter in patients with SP revealed 32% of position -1082 guanine into adenine (c. Despite the fact that the global prevalence notified of the allele frequencies of -1082, -819, and -592 SNPs in IL-10 gene in control groups vary, and they are same to last studies in Turkish society [13,21,22].…”

Section: Discussionsupporting

confidence: 54%

“…IL-10 gene -1082, -819, and -592 positions of the proximal promoter are the most studied polymorphisms. The presence of common allelic combinations in these three SNPs, their linkage disequilibrium and varying IL-10 serum levels that depend on their combinations has been confirmed in several studies [12,13].…”

Section: Discussionmentioning

confidence: 70%

“…In this study, the IL-10 gene SNPs -1082, -819, -592 and their genotypic combinations in 100 SP patients and 100 volunteer-healthy controls in the Turkish population were Wide variation has been also recorded in the frequencies of IL-10 gene's promoter SNPs among distinct populations. Despite the fact that the global prevalence notified of the allele frequencies of -1082, -819, and -592 SNPs in IL-10 gene in control groups vary, and they are same to last studies in Turkish society [13,21,22].…”

Section: Discussionmentioning

confidence: 83%

“…Also the final extension was at 72 0 C for 10 min. The amplified products were verified by 2% agorose gel ilibrium leading to variations in expression level and are associated with various disease pathogenesis [12,13].…”

Section: Genotypingmentioning

confidence: 99%

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Combinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis

Özdaş¹

2018

Hittite J. Sci. Eng.

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Sinonasal polyposis (SP) is a cronic inflammation of the sinonasal mucosa. Chronic sinusitis, odor loss headache and nasal obstruction are among the clinical symptoms of SP with low life quality among the patients. Sinonasal polyposis is often accompanied by allergic rhinitis, allergy, aspirin susceptibility and asthma [1]. SP has been implicated in many immunological pathways and is a localized manifestation of systemic disorders [2,3]. SP cases frequently accompanied by T helper (Th) type 1-, Th2-, or Th17-biased inflammatory processes regulated by increased expression levels of a number of cytokines with pro-and anti-inflammatory activities [4]. However, the underlying etiology of SP is multifactorial. Also the pathogenesis of SP is still unexplained.Interleukin (IL)-10 is a crucial Th2 group anti-inf-

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 83%

Section: Genotypingmentioning

confidence: 99%

See 2 more Smart Citations

Combinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis

Özdaş¹

2018

Hittite J. Sci. Eng.

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“…OSAS is a complex and multifactorial syndrome, and it is believed that some specific genes may play a crucial role in its pathogenesis, particularly involved in the expression of the CLOCK gene [7], IL-10 polymorphisms [8], and insulin variable number of tandem repeat (INS VNTR) sequence regulation [9].…”

Section: Risk Factorsmentioning

confidence: 99%

Neuropsychological Alterations in Children Affected by Obstructive Sleep Apnea Syndrome

Carotenuto

Marotta

Precenzano

et al. 2021

Updates in Sleep Neurology and Obstructive Sleep Apnea

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Sleep-related breathing disorders are a group of clinical conditions ranging from habitual snoring to obstructive sleep apnea syndrome (OSAS) during the lifespan. In children, other risk factors are represented by adenotonsillar hypertrophy, rhinitis, nasal structure alteration, cleft palate, velopharyngeal flap surgery, pharyngeal masses, craniofacial malformations, genetic syndrome (i.e. Down syndrome, Crouzon syndrome, and Apert syndrome), genetic hypoplasia mandibular (i.e. Pierre Robin syndrome, Treacher Collins syndrome, Shy-Drager syndrome, and Cornelia De Lange syndrome), craniofacial traumas, chronic or seasonal rhinitis, asthma, neuromuscular syndromes, brainstem pathologies (i.e. Arnold-Chiari malformation and Joubert syndrome), achondroplasia, and mucopolysaccharidosis. OSAS may affect the executive functioning such as motivational ability, planning, behavior modulation, ability to complete an action program, identification of functional strategies to achieve the goal, problem solving, flexibility, monitoring and self-assessment of behavior in relation to results, change of task, or behavior in the light of emerging information, which may be all impaired by nocturnal intermittent hypoxia also during the developmental age. The clinical presentation of OSAS can mimic other neurobehavioral symptoms, such as ADHD syndrome, learning problems, or can exacerbate the Fragile X syndrome, and generalized nonconvulsive epilepsy symptoms.

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Bioinformatics analysis to reveal the key genes related to obstructive sleep apnea

Yang

Luo

et al. 2018

Sleep Breath

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Association of Interleukin-10 gene promoter polymorphisms with obstructive sleep apnea

Cited by 8 publications

References 35 publications

Combinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis

Combinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis

Neuropsychological Alterations in Children Affected by Obstructive Sleep Apnea Syndrome

Bioinformatics analysis to reveal the key genes related to obstructive sleep apnea

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