Association of Interleukin-11 with Mortality in Patients with Spontaneous Basal Ganglia Haemorrhage

Tu, CJ; Liu, WG; Dong, XQ; Js, Lee; Song, DG; Wh, Yu; Zy, Zhang; Zhen, Genshen; Luo, Haidong

doi:10.1177/147323001103900414

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…A large number of studies have shown that the inflammatory mediators could destroy the blood-brain barrier (BBB) after cerebral hemorrhage, directly damage brain tissue and aggravate the disease. The level of interleukin increased in HS patients, which blocked neuroprotective activation effects, and positively correlated with the disease severity[1][2]. The expressions of tumor necrosis factor-α, monocyte chemotactic protein-1 and intercellular adhesion molecule-1 increased significantly in cerebral hemorrhage after 24h, and the inhibition of the these factors expression could alleviate brain tissue damage[3].…”

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confidence: 97%

The expression of cerebrospinal fluid pentraxin-3 in patients with hemorrhagic stroke

Zhu

Guo

et al. 2019

Preprint

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Background: There exists brain tissue inflammation and endothelial function damage in stroke. Method: We investigated serum and cerebrospinal fluid (CSF) levels of PTX3, HSP70, VEGF, IL-6, CRP in patients with stroke, this study was conducted on 85 standard stroke patients during 2015-2016, include ischemic stroke (IS) group (52 cases) and hemorrhagic stroke (HS) group (33 cases). The patients without inflammatory and neurological disease were the control group (20 cases). The levels of PTX3, HSP70, VEGF, IL-6 and CRP in serum on the 1th, 5th and 14th day after admission were measured and compared them with that in cerebrospinal fluid, NIHSS and Barthel score were also performed for assessing patients with HS. The results showed that the serum levels of PTX3, HSP70, VEGF, IL-6, CRP with HS were higher than that with IS patients (P<0.001, P=0.16, P=0.08, P=0.12, P<0.001, respectively), and PTX3 level began to fall after 14th day (P=0.015). The cerebrospinal fluid of PTX3, HSP70,VEGF and IL-6 levels in patients with HS were higher than that of normal control group (P=0.002, P=0.003, P<0.001, P<0.001, respectively). The levels of PTX, HSP70, IL-6 in cerebrospinal fluid were higher than that in the serum (P=0.026, P<0.001, P<0.001, respectively), and VEGF, CRP instead (P=0.011, P<0.001, respectively). The level of PTX3 in cerebrospinal fluid was positively correlated with IL-6 in patients with HS (P<0.001), PTX3 and IL-6 in patients with HS were positively correlated with patients' NIHSS score (P=0.007, P<0.001, respectively), and negatively correlated with Barthel index score (P=0.023, P<0.001, respectively). Inflammation and endothelial damage were more severe in patients with HS. The levels of PTX3 and IL-6 in cerebrospinal fluid could assess the severity, progression, and prognosis of HS. PTX3 may be a potential biomarker in HS, it could provide potent basis for doctors to select appropriate treatment measures as soon as possible.

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confidence: 97%

The expression of cerebrospinal fluid pentraxin-3 in patients with hemorrhagic stroke

Zhu

Guo

et al. 2019

Preprint

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“…with rheumatoid arthritis (Chung et al, 2011) and with patient mortality in basal ganglia hemorrhage (Tu et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase

Balakrishnan

Soman

Patil

et al. 2013

Cell Communication & Adhesion

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Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a signifi cant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein -protein interactions, 26 enzyme -substrate reactions, 7 translocation events, and 4 activation/ inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from ' NetPath ' , a repository for signaling pathways. We believe that this will help in the identifi cation of potential therapeutic targets in IL-11-associated disorders.

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Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

Zhu

Wang

et al. 2019

Progress in Neurobiology

238

174

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Association of Interleukin-11 with Mortality in Patients with Spontaneous Basal Ganglia Haemorrhage

Cited by 3 publications

References 37 publications

The expression of cerebrospinal fluid pentraxin-3 in patients with hemorrhagic stroke

The expression of cerebrospinal fluid pentraxin-3 in patients with hemorrhagic stroke

IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase

Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

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