Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan

Abstract

Asthma is an inflammatory disease and interleukin 12 (IL-12) may play a regulatory role in allergen-induced inflammation. The aim of this study was to investigate the association of polymorphisms in IL-12A/IL-12B with asthma. The asthma group included 198 adult patients and the control group included 453 individuals without asthma that were frequency-matched by gender and age. The distribution of genotypic and allelic frequencies of IL-12A rs568408 demonstrated significant differences between case and control groups. Specifically, the percentages of AA genotype of IL-12A rs568408 was significantly higher among asthmatic patients in Taiwan than healthy controls, compared to GG genotype. No significant difference was observed among the IL-12A rs2243115 and IL-12B rs3212227 genotypes between case and control groups. In addition, the A allele at IL-12A rs568408 was associated with more severe symptoms (P = 0.0085) among asthmatic patients. These results suggest that IL-12A rs568408 may contribute to the etiology and symptoms severity of asthma, indicating its usefulness as a predictive and diagnostic biomarker of asthma.

Genetic polymorphism in association with susceptibility to tuberculosis: a study in a Pakistani population

“…For instance, rs428253 is associated with the risk of coronary heart disease [25] while has protective effects against allergic rhinitis [16]. Similarly, rs568408 and not rs2243115 is associated with asthma [26]. Furthermore, a significant association of the incidence of TB was observed with demographic factors such as gender, age, smoking pattern, and the presence of TB in a family history.…”

Papel del polimorfismo de un simple nucleótido de la interleucina 12 y la expresión de IFN-gamma en la respuesta de anticuerpos a la vacuna recombinante contra el virus de la hepatitis B

“…Se conoce que la inmunidad contra el VHB es regulada por factores genéticos del hospedero, como las variantes alélicas de SNP de genes de la respuesta inmune y la expresión de ARNm de IFN-γ (4,9). La distribución de la frecuencia de alelos de IL-12A e IL-12B SNP fue similar a la identificada en los pacientes de Polonia y de Taiwán (10,11). En contraste con otros estudios realizados en población Septiembre 2019 Volumen 30 Número 3 https://doi.org/10.32776/revbiomed.v30i3.694 asiática y caucásica, el genotipo CC de IL-12B no fue detectado en esta población (12).…”

Association of Polymorphisms in DNA Repair GeneXRCC3with Asthma in Taiwan

“…Genotyping conditions. Genomic DNA from the peripheral blood leucocytes of each patient and matched control was prepared using the QIAamp Blood Mini Kit (Blossom, Taipei, Taiwan) and further processed as per our previous articles (24,25).…”