Association of interleukin-18 gene promoter polymorphisms with coronary artery disease in northern Iranian population

Bazgir, Afsaneh; Farazmandfar, Touraj; Salehi, Aref; Manzari, Reza Salehi; Attar, Marzieh; Shahbazi, Majid

doi:10.1016/j.mgene.2018.01.001

Cited by 8 publications

(6 citation statements)

References 17 publications

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“…Although the the mechanism is not unknow and the research of that is limited, the role of inflammation in the occurrence of atherosclerotic plaques cannot be ignored [ 11 ]. Angina and myocardial infarction can be considered as some of the clinical indicators of this disorder [ 11 – 13 ]. Several types of immune cells, including macrophages,and T and B lymphocytes also accumulate in the arterial walls and are involved in the development of atherosclerotic disorders through cytokines and other mediators [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis

et al. 2021

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Background Coronary Artery Disease (CAD) is caused by the blockage of the coronary arteries. it is argued that there has an association between the Interleukin-6 gene and the occurrence of atherosclerosis, coronary artery disease, Due to the short half-life and high variability of Interleukin-6 (IL-6), limited studies have been performed on the association of serum levels of interleukin-6 with coronary artery disease. The aim of this study is to investigate the relationship between IL-6 gene polymorphisms and coronary artery disease. Methods This study was conducted as a meta-analysis of selected articles with no lower time limit and upto March 2020. Articles related to the subject were obtained by searching several data sources,such as the SID, IranDoc, Scopus, Embase, Web of Science (ISI), PubMed, Science Direct, and Google Scholar databases. The heterogeneity of the studies was assessed using the I2 index in the Comprehensive Meta-Analysis software. Results The GG genotype of the IL-6174 G> C polymorphism with a 0.8 odds ratio tended to reduce the risk of CAD by 20%. The odds ratio of CAD in CG and GG genotypes were found to be 1.16 and 1.48 times respectively, indicating the increasing effect of these two genotypes. In the IL-6-572 C>G polymorphism, CG and GG genotypes increased the risk of CAD by 1.21 and 1.27 times respectively, and the CC genotype tended to reduce the risk of CAD by 15%, considering the odds ratio of 0.85. Conclusion This study showed a relationship between IL-6174G> C and Interleukin-6 (IL-6) 572 C>G genes and coronary artery disease. Moreover, the protective effects of GG genotype in IL-6 gene 174 G> C and CC genotype in IL-6 gene 572 C>G gene were reported. The study also confirmed that the CG and CC genotypes of the G>C IL-6174 gene have an increasing effect on coronary artery disease. Moreover, CG and GG genotypes in the IL-6 gene 572 C>G increased the risk of developing CAD. It should be noted that the increased risk of developing CAD was limited to meta-analytic studies in reported literatures.

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Section: Introductionmentioning

confidence: 99%

The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis

et al. 2021

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“…Previously, we showed a correlation between polymorphisms in PDGF-B, IL-10, IL-18, IFN-γ, and CAD. [15][16][17][18] As AGT is an important regulator of cell proliferation and vessel thickness, we conducted a retrospective case-control study to determine the correlation between rs5051 and rs699 polymorphisms in this gene and CAD. Using mutagenically separated-polymerase chain reaction (MS-PCR) and sequence-specific primer-PCR (SSP-PCR), our findings indicated that there is a significant association between A allele of rs5051 and C allele of rs699 polymorphisms and CAD.…”

Section: Introductionmentioning

confidence: 99%

“…Previously, we showed a correlation between polymorphisms in PDGF-B, IL-10, IL-18, IFN-γ, and CAD. [15–18]…”

Section: Introductionmentioning

confidence: 99%

Association of rs5051 and rs699 polymorphisms in angiotensinogen with coronary artery disease in Iranian population: A case-control study

Mirahmadi,

Salehi,

Golalipour

et al. 2024

Medicine

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Coronary artery disease (CAD) is the third most common cause of mortality globally (with 17.8 million deaths annually). Angiotensinogen (AGT) and polymorphisms in this gene can be considered as susceptibility factors for CAD. We performed a retrospective case-control study to determine the correlation of AGT rs5051 and rs699 polymorphisms with CAD in an Iranian population. We genotyped 310 CAD patients and 310 healthy subjects using polymerase chain reaction-based methods. To confirm the accuracy of the screening approach, 10% of genotyped subjects were validated using gold-standard Sanger Sequencing. To evaluate the effect of the candidate polymorphisms, white blood cells were randomly purified from the subjects and AGT expression was measured by quantitative reverse transcriptase-polymerase chain reaction. Sex stratification indicated a significant correlation between CAD and male sex (P = .0101). We found a significant association between the rs5051 A allele (P = .002) and the rs699 C allele, and CAD (P = .0122) in recessive and dominant models. Moreover, our findings showed a significant association of the haplotype, including the rs5051 A/A and rs699 T/C genotypes, with CAD (P = .0405). Finally, AGT mRNA levels were significantly decreased in patients harboring the candidate polymorphisms (P = .03). According to our findings The AGT rs5051 A and AGT rs699 C alleles are predisposing variants of CAD risk and severity in the Iranian population.

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“…Its sequence incorporated speci c SNPs in the promoter region, affecting its transcriptional activity and altering its expression level (Zhen et al, 2019). The most common ones are − 137G/C (rs187238) and − 607C/A (rs1946518) polymorphisms, which have been widely studied for their association with the risk of several immune disorders like coronary heart disease, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and MS (Bazgir et al, 2018, Umare et al, 2019, Gomes da Silva et al, 2020, Bakr et al, 2021. Still, not much research has been done to investigate the link between MS and the IL-18-137G/C (rs187238) SNP.…”

Section: Introductionmentioning

confidence: 99%

Impact of Genetic Polymorphisms in the Interleukin-18 and Interleukin-21 Genes on the Risk and Clinical Outcomes of Multiple Sclerosis

Bakr,

Hashim,

El-Eshmawy

et al. 2024

Preprint

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To study the association between IL-18-137G/C (rs187238) and IL-21-1472G/T (rs2055979) single nucleotide polymorphisms (SNPs) with the risk of MS, the disease progression, as well as the clinical features. 271 Egyptian individuals have participated in this present search, of whom 99 cases and 140 were unrelated healthy controls. For the IL-18-137G/C SNP, the GC genotype and C allele were linked to susceptibility to MS, and the GC and CC genotypes and C allele were linked to a higher risk of developing progressive MS. Regression investigation further strengthened the notion that this SNP is a predictor of the disability of the disease according to the Disability Status Scale (EDSS) values. For the IL-21-1472G/T SNP, the TT genotype and T allele were associated with the decreased risk of progressive MS in the Egyptian cohort when comparing the two diseased forms; however, they were not associated with the disability progression and severity of the disease. The IL-18-137G/C SNP could be a possible risk factor for the susceptibility and progression of MS. In contrast, the IL-21-1472G/T SNP could protect against progressive MS.

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Association of interleukin-18 gene promoter polymorphisms with coronary artery disease in northern Iranian population

Cited by 8 publications

References 17 publications

The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis

The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis

Association of rs5051 and rs699 polymorphisms in angiotensinogen with coronary artery disease in Iranian population: A case-control study

Impact of Genetic Polymorphisms in the Interleukin-18 and Interleukin-21 Genes on the Risk and Clinical Outcomes of Multiple Sclerosis

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