Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis

Wang, Y.S.; Liu, L.; Xu, Xiaolong; Wang, J.L.; Zhou, Huanjiao Jenny; Li, T.L.; Liang, Zongan

doi:10.4238/2015.may.4.5

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…In our report, a 72-year-old male, a chronic smoker serotonin and histamine show a high levels in COPD patients [14,15].…”

Section: Case Reportmentioning

confidence: 45%

Salbutamol Inhalation Could Induce Fatal Multi-Vessel Coronary Artery Spasm in COPD Patients

Li¹,

Zhang²,

Shao³

2018

J Geriatr Med Gerontol

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Coronary artery spasm is a sudden and intense vasoconstriction of single-or multi-vessel coronary artery. It may be triggered by several acute stress. This case reports 72-yearold male with salbutamol inhalation suffer fatal multi-vessel coronary artery spasm. After intracoronary administration of nitroglycerin, coronary artery spasm was relieved. It reminds us to be cautious of β-agonist administration in respiratory patients with coronary artery spasm risk.

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“…In our report, a 72-year-old male, a chronic smoker serotonin and histamine show a high levels in COPD patients [14,15].…”

Section: Case Reportmentioning

confidence: 45%

Salbutamol Inhalation Could Induce Fatal Multi-Vessel Coronary Artery Spasm in COPD Patients

Li¹,

Zhang²,

Shao³

2018

J Geriatr Med Gerontol

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“…These meta-analyses included a mean of 6 studies (range 1–15) and 5587 participants (range 220–100777). Except 48 statistically nonsignificant associations, 9 significant associations were identified in the stratified analysis by ethnicity [ 8 , 36 , 42 , 54 , 55 , 59 , 65 , 70 ]. Only 4 associations met the following criteria for further assessment: genetic model must be an allelic model, and significant association was congruously confirmed across studies.…”

Section: Resultsmentioning

confidence: 96%

Genetic Variants Associated with Chronic Obstructive Pulmonary Disease Risk: Cumulative Epidemiological Evidence from Meta-Analyses and Genome-Wide Association Studies

Liu

Ran

et al. 2022

Canadian Respiratory Journal

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Background. Last two decades, many association studies on genetic variants and chronic obstructive pulmonary disease (COPD) risk have been published. But results from different studies are inconsistent. Therefore, we performed this article to systematically evaluate results from previous meta-analyses and genome-wide association studies (GWASs). Material and Methods. Firstly, we retrieved meta-analyses in PubMed, Embase, and China National Knowledge Infrastructure and GWASs in PubMed and GWAS catalog on or before April 7th, 2022. Then, data were extracted and screened. Finally, two main methods—Venice criteria and false-positive report probability test—were used to evaluate significant associations. Results. As a result, eighty-eight meta-analyses and 5 GWASs were deemed eligible for inclusion. Fifty variants in 26 genes obtained from meta-analyses were significantly associated with COPD risk. Cumulative epidemiological evidence of an association was graded as strong for 10 variants in 8 genes (GSTM1, CHRNA, ADAM33, SP-D, TNF-α, VDBP, HMOX1, and HHIP), moderate for 6 variants in 5 genes (PI, GSTM1, ADAM33, TNF-α, and VDBP), and weak for 40 variants in 23 genes. Five variants in 4 genes showed convincing evidence of no association with COPD risk in meta-analyses. Additionally, 29 SNPs identified in GWASs were proved to be noteworthy based on the FPRP test. Conclusion. In summary, more than half (52.38%) of genetic variants reported in previous meta-analyses showed no association with COPD risk. However, 13 variants in 9 genes had moderate to strong evidence for an association. This article can serve as a useful reference for further studies.

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“…A meta-analysis of available data presents the precise estimation of the effects of the polymorphisms. Previous meta-analyses showed that IL1β polymorphisms affect the risk of various clinical conditions and cancers ( 46 - 48 ). However, to this date, no meta-analysis study has reported a precise correlation between IL1β polymorphisms and the risk of gestational disorders.…”

Section: Discussionmentioning

confidence: 99%

Relationship between common interleukin 1-beta gene polymorphisms and the risk of gestational disorders: An updated meta-analysis

Harati‐Sadegh

Sargazi

Taheri

et al. 2021

mjiri

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Background: To quantitatively estimate the relationship between IL‐1β -511C>T, −31T>C, and +3954C>T polymorphisms and risk of gestational disorders. Methods: In this meta-analysis, eligible publications were searched in Web of Knowledge, MEDLINE, PubMed, Scopus, and Google Scholar databases (updated April 2020), using appropriate or relevant keywords. Case-control population-based reports were included if provided with genotypic frequencies of both studied groups. Statistical analyses were performed using the MetaGenyo web tool software, where a P value less than 0.05 indicated a significant association. For the assessment of between-study variations, heterogeneity analysis was applied with the I 2 statistics. Results: A total of thirteen studies were included. We observed a significant association between IL‐1β−31T>C polymorphism and reduced risk of gestational disorders under codominant CT vs. CC [OR= 0.74, CI (0.59-0.92)], and dominant CT+TT vs. CC [OR= 0.74, CI (0.60-0.91)] contrasted genetic models. The stratified analysis considering the disease type showed that the 511C>T variant, under the recessive CC vs. CT+TT model, enhanced the risk of preterm birth by 1.29 fold. Conclusion: Our results failed to support an association between two IL‐1β polymorphisms, 511C>T and +3954C>T, with the overall risk of gestational disorders. In contrast, the 31T>C variant reduced the incidence of such diseases. Further studies are encouraged to get more precise estimates of effect sizes.

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Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis

Cited by 8 publications

References 21 publications

Salbutamol Inhalation Could Induce Fatal Multi-Vessel Coronary Artery Spasm in COPD Patients

Salbutamol Inhalation Could Induce Fatal Multi-Vessel Coronary Artery Spasm in COPD Patients

Genetic Variants Associated with Chronic Obstructive Pulmonary Disease Risk: Cumulative Epidemiological Evidence from Meta-Analyses and Genome-Wide Association Studies

Relationship between common interleukin 1-beta gene polymorphisms and the risk of gestational disorders: An updated meta-analysis

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