2018
DOI: 10.1111/cei.13133
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Association of interleukin 22 gene polymorphisms and serum IL-22 level with risk of systemic lupus erythematosus in a Chinese population

Abstract: The aim of this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) of the interleukin 22 (IL-22) gene and systemic lupus erythematosus (SLE) in a Chinese population. Three IL-22 SNPs (rs2227485, rs2227513 and rs2227491) were genotyped using SNaPshot SNP genotyping assays and identified by sequencing in 314 SLE patients and 411 healthy controls. The IL-22 level of serum was assessed by enzyme-linked immunosorbent assay (ELISA) kits. Data were analysed by spss version 17.… Show more

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Cited by 16 publications
(25 citation statements)
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“…18 In the present study, three strains (3.5%) were ESBL producers detected by the double disc synergy test which is supported by the results of Kotwal et al in which 6% of ESBL were detected among cefepime resistant P. aeruginos. 19,20 While the findings of Wolska and Jakubczak, (2008) showed no ESBL detection in P. aeruginosa isolates. 21 However, it is in contrast to the study conducted in Pakistan, where 35.8% strains of P.aeruginosa were ESBL-producers.…”
Section: Discussionmentioning
confidence: 89%
“…18 In the present study, three strains (3.5%) were ESBL producers detected by the double disc synergy test which is supported by the results of Kotwal et al in which 6% of ESBL were detected among cefepime resistant P. aeruginos. 19,20 While the findings of Wolska and Jakubczak, (2008) showed no ESBL detection in P. aeruginosa isolates. 21 However, it is in contrast to the study conducted in Pakistan, where 35.8% strains of P.aeruginosa were ESBL-producers.…”
Section: Discussionmentioning
confidence: 89%
“…Similarly, an elevated frequency of the rs2046068-rs2227491 A-G haplotype was observed in the control group. Wang et al did not find any association between the rs2227491 and serum IL-22 levels of the control group in SLE cases in a Chinese population [20]. With the haplotype analysis for the level of parasite density when comparing cohort I+II with III +IV, the results showed a significantly higher frequency of the rs1179246-rs1182844-rs2046068-rs2227491-rs2227481-rs2227478 C-A-C-A-C-C haplotype in the I+II cohort.…”
Section: Discussionmentioning
confidence: 93%
“…Also, Hu et al reported a high possibility of HIV infection with the rs2227513 AG genotype [39]. It was also suggested that there is a positive association between the rs2227513 AG genotype and susceptibility to SLE [20]. The latter study showed that the levels of the IL-22 cytokine were statistically less in the AG genotype in contrast to AA genotype, signifying that the rs2227513 AG genotype increases the risk of SLE by reducing the IL-22 cytokine levels [20].…”
Section: Discussionmentioning
confidence: 95%
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