2023
DOI: 10.3389/fped.2023.1118137
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Association of interleukin-4, interleukin-13 gene polymorphisms, HLA-DQ and DR genotypes with genetic susceptibility of type-1 Diabetes Mellitus in Kuwaiti children

Abstract: BackgroundType-1 diabetes mellitus (T1DM) is a complex multifactorial disease with an autoimmune etiology and is thought to result from an interaction between genetic and non-genetic factors. Cytokines play a crucial role in the pathogenesis of autoimmune diseases due to their effector and regulatory functions in immune responses. Interleukin-4 (IL4) and Interleukin-13 (IL13) are anti-inflammatory cytokines and are considered as important mediators in pathology of the autoimmune diseases.MethodsWe have determi… Show more

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Cited by 4 publications
(2 citation statements)
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“…A previous study on vitamin D receptor polymorphisms has shown significant association of Fok I and Taq I with susceptibility to T1D in Kuwaiti children 32 . Variations in interleukin 4 and interleukin 13 genes are additionally associated with susceptibility to T1D and their co-inheritance with high-risk HLA haplotypes are reported in Kuwaiti children 33 . Our recent study has revealed differential methylation profile of islet cell autoantigen 1, a prominent marker for beta cell autoimmunity in Kuwaiti T1D families 19 .…”
Section: Introductionmentioning
confidence: 98%
“…A previous study on vitamin D receptor polymorphisms has shown significant association of Fok I and Taq I with susceptibility to T1D in Kuwaiti children 32 . Variations in interleukin 4 and interleukin 13 genes are additionally associated with susceptibility to T1D and their co-inheritance with high-risk HLA haplotypes are reported in Kuwaiti children 33 . Our recent study has revealed differential methylation profile of islet cell autoantigen 1, a prominent marker for beta cell autoimmunity in Kuwaiti T1D families 19 .…”
Section: Introductionmentioning
confidence: 98%
“…In addition, the significance of IL13 polymorphisms has been documented in clinical phenotypes that serve as risk factors for MI, such as type-1 diabetes mellitus, hypertension, and dyslipidemia. Specifically, in Kuwaiti children, the rs20541 variant was associated with susceptibility to T1DM [ 19 ]. Conversely, genetic variants in the IL13 gene failed to demonstrate an association with T1DM in Filipino [ 20 ], British [ 21 ], and Thai populations [ 22 ].…”
Section: Introductionmentioning
confidence: 99%