Association of Interleukin-6 and Myeloperoxidase with Insulin Resistance in Impaired Fasting Glucose Subjects

Abstract

Impaired fasting glucose (IFG) is a high risk subclinical condition for the progression of type 2 diabetes mellitus and the hyperglycemia seen in this condition is because of the development of insulin resistance (IR). Obesity, inflammation, oxidative stress and many other factors have been implicated in development of IR in type 2 diabetes mellitus and its successive complications. Current study was aimed to ascertain the correlation of inflammation and oxidative stress markers [interleukin-6 (IL-6) and myeloperoxidase (MPO)] with IR in subjects with IFG. In this study, 80 subjects (40 IFG, 40 healthy controls) aged 25-45 years were selected based on their fasting plasma glucose (FPG) values and clinical history. Serum insulin, IL-6 and MPO were estimated by ELISA method and IR was calculated using Homeostatic Model Assessment Index 2 (HOMA 2) calculator. Pearson's correlation coefficient and independent sample 't' test were used for statistical analysis. IL-6 and MPO were found to be significantly elevated in IFG group and both correlates significantly with IR (r 0.413, r 0.645). Only MPO had significant correlation with FPG (r 0.388). In conclusion, the association of altered levels of IL-6 and MPO with IR are suggestive of a role of inflammation and oxidative stress in the initiation and progression of IR in individuals with IFG.

Glycemic control and adipokines after periodontal therapy in patients with Type 2 diabetes and chronic periodontitis

“…Agarwal A compared 40 patients with impaired fasting glucose (IFG) with 40 healthy people, and IL-6 was found to be significantly elevated in the IFG group and to significantly correlate with IR. 32 A prospective cohort study conducted by Bertoni AG 33 found that serum IL-6 levels are significantly associated with T2DM. IL-6 induces IR through the prevention of non-oxidative glucose metabolism and the suppression of lipoprotein lipase, which increases the triglyceride level.…”

Association of Impaired Fasting Glucose and Diabetes with SARS-CoV-2 Spike Antibody Titers after the BNT162b2 Vaccine among Health Care Workers in a Tertiary Hospital in Japan

“…The present finding is supported by data from biomarker studies. Compared with individuals with normoglycemia, those with IFG had higher serum concentrations of proinflammatory cytokine interleukin 6 [ 13 , 14 ], which is a sign of an impaired immune system [ 26 ]. Additionally, we found a linear, inverse relationship between FPG levels and SARS-CoV-2 spike IgG antibody titers above an FPG of 90 mg/dL, suggesting that keeping lower concentrations of FPG within the nondiabetic range is preferable for enhancing vaccine-induced antibody production.…”

“…Most of these studies assessed diabetes based on participants’ self-report [ 9 , 10 , 12 ], which may miss undiagnosed diabetes. Along with diabetes, impaired fasting glucose (IFG) has been shown to be associated with immunologic abnormalities [ 13 , 14 ]. To the best of our knowledge, no studies have assessed the correlation between IFG and SARS-CoV-2 vaccine-induced antibody production.…”

Jak2 Inhibitor AG490 Improved Poststroke Central and Peripheral Inflammation and Metabolic Abnormalities in a Rat Model of Ischemic Stroke

“…Interleukin-6 (IL-6) is a pleiotropic cytokine, adipokine, and myokine [ 12 ]. Accumulating evidence indicates that IL-6 is involved in oxidative stress and inflammation in adipose, skeletal muscles, and hepatic tissues [ 13 , 14 , 15 , 16 ] in association with insulin resistance and impaired fasting glucose [ 17 ]. Receptors involved in the recognition of IL-6 include the ligand-specific IL-6 receptor (IL-6R) and the signal-transducing receptor gp130 [ 12 ].…”