Association of Interleukin‐6 and Other Biologic Variables with Depression in Older People Living in the Community

Dentino, Andrew; Pieper, Carl F.; Rao, K. Murali Krishna; Currie, Mark S.; Harris, Tamara B.; Blazer, Dan G.; Cohen, Harvey Jay

doi:10.1111/j.1532-5415.1999.tb01894.x

Cited by 258 publications

(173 citation statements)

References 34 publications

(56 reference statements)

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“…Both depression and type 2 diabetes are found to be associated with increased Creactive protein, TNF-α and proinflammatory cytokines, including IL-6 [38][39][40][41][42]. A contradiction between this hypothesis and the first hypothesis is that cortisol inhibits inflammation and the immune response, whereas depression is associated with both elevated cortisol and increased inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis

et al. 2006

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Aims/hypothesis: Evidence strongly suggests that depression and type 2 diabetes are associated, but the direction of the association is still unclear. Depression may occur as a consequence of having diabetes, but may also be a risk factor for the onset of type 2 diabetes. This study examined the latter association by reviewing the literature and conducting a meta-analysis of longitudinal studies on this topic. Methods: Medline and PsycInfo were searched for articles published up to January 2005. All studies that examined the relationship between depression and the onset of type 2 diabetes were included. Pooled relative risks were calculated using fixed and random effects models. To explore sources of heterogeneity between studies, subgroup analyses and meta-regression analyses were performed. Results: Nine studies met our inclusion criteria for this meta-analysis. The pooled relative risk was 1.26 (1.13-1.39) using the fixed effects model and 1.37(1.14-1.63) using the random effects model. Heterogeneity between studies could not be explained by (1) whether studies controlled for undetected diabetes at baseline; (2) the method of diabetes assessment at followup; (3) the baseline overall risk of diabetes in the study population; and (4) follow-up duration. Conclusions/ interpretation: Depressed adults have a 37% increased risk of developing type 2 diabetes mellitus. The pathophysiological mechanisms underlying this relationship are still unclear and warrant further research. A randomised controlled study is needed to test whether effective prevention or treatment of depression can reduce the incidence of type 2 diabetes and its health consequences.

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Section: Discussionmentioning

confidence: 99%

Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis

et al. 2006

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“…(Dentino et al, 1999;Penninx et al, 2003;Tiemeier et al, 2003;Ford, Erlinger, 2004;Liukkonen et al, 2006;Cyranowski et al, 2007;Dantzer, Kelley, 2007;Ranjit et al, 2007;Bremmer et al, 2008) The cognitive symptoms of depression can be considered an indicator of early stages of clinically diagnosed depression. (Fogel et al, 2006) Thus, our results suggest that inflammation plays a role as an initiator and contributor to the progression of depression rather than contributing to the later stages of depression development.…”

Section: Inflammation As a Predictor Of Depressive Symptomsmentioning

confidence: 99%

“…(Danesh et al, 2004) Both experimental and epidemiological research have found that depressed people have higher plasma levels of inflammatory markers. (Dentino et al, 1999;Penninx et al, 2003;Tiemeier et al, 2003;Ford, Erlinger, 2004;Liukkonen et al, 2006;Cyranowski et al, 2007;Dantzer, Kelley, 2007;Ranjit et al, 2007;Bremmer et al, 2008) However, experimental research is based on small clinical samples, and previous epidemiological research, despite large samples and thorough covariate assessment, is cross-sectional. Generally these studies have examined short-term associations between depression and inflammation, while examination of longer term associations is scarce.…”

Section: Introductionmentioning

confidence: 99%

Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study

et al. 2008

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Background-A lack of longitudinal studies has made it difficult to establish the direction of associations between circulating concentrations of low-grade chronic inflammatory markers, such as C-reactive protein and interleukin-6, and cognitive symptoms of depression. The present study sought to assess whether C-reactive protein and interleukin-6 predict cognitive symptoms of depression or whether these symptoms predict inflammatory markers.

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“…IL-6 is proposed to be involved in the pathophysiology of MDD. In particular, it was suggested that IL-6 is involved in multiple physiological systems, including the hypothalamic-pituitary-adrenal axis, corticotrophin-releasing hormone activity at limbic sites, noradrenaline utilization, the release of oxidative stress, apoptotic pathways, and kinase signaling, all of which have very close relationships to the pathophysiology of MDD [13][14][15]. Li et al recently showed that noradrenaline significantly increased the mRNA and protein expressions of IL-6 in U937 macrophages in time-and concentration-dependent manners [16].…”

Section: Discussionmentioning

confidence: 99%

Plasma Interleukin 6 Predicts Response to Serotonin Noradrenaline Reuptake Inhibitors in Major Depressive Disorder

Yoshimura¹

2017

Biomark J

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We investigated the association between the plasma interleukin-6 (IL-6) level and response to Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) in Major Depressive Disorder (MDD) patients. Patients with MDD diagnosed by DSM-IV-TR (M/F: 45/52, mean age 48 years) were enrolled in the present study. All participants were treated by monotherapy of duloxetine (n=48) or milnacipran (n=49). The end-point of the present study was week 8. Patients whose HAMD17 scores decreased 50% or more were defined as responders; others were considered nonresponders. Blood was drawn at baseline and 8 weeks after the treatment. Plasma levels of IL-6 were measured. Plasma IL6 at week 0 was higher in the responder group than in the nonresponders group. Plasma IL6 level in the responder group significantly decreased 8 weeks after treatment with antidepressant. These results suggest that plasma IL-6 is related to the response to SNRIs in MDD patients.

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Association of Interleukin‐6 and Other Biologic Variables with Depression in Older People Living in the Community

Abstract: These data suggest that the inflammatory marker, IL-6, is associated with depression in older people in this cross-sectional study. These results are compatible with the hypothesis of cytokine (IL-6) stimulation in geriatric depression as part of an overall immunoendocrine dysregulation.

Cited by 258 publications

References 34 publications

Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis

Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis

Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study

Plasma Interleukin 6 Predicts Response to Serotonin Noradrenaline Reuptake Inhibitors in Major Depressive Disorder

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