Association of interleukin-6 genetic polymorphisms with risk of OSCC in Indian population

Singh, Prithvi; Chandra, Girish; Bogra, Jaishri; Gupta, Rajni; Kumar, Vijay; Jain, Amita; Hussain, Syed Rizwan; Mahdi, Abbas Ali; Ahmad, Mohammad Kaleem

doi:10.1016/j.mgene.2015.03.002

Cited by 20 publications

(28 citation statements)

References 45 publications

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“…For −572 G/C polymorphism, MbiI fast digestion restriction enzyme at 37°C was used yielded G allele (102, 61) bp and C allele (163) bp products. The obtained fragments’ sizes were analysed on a 2% agarose gel [13]. …”

Section: Methodsmentioning

confidence: 99%

Assessment of the âˆ’174G/C (rs1800795) and âˆ’572G/C (rs1800796) Interleukin 6 Gene Polymorphisms in Egyptian Patients with Rheumatoid Arthritis

Amr

El-Awady

Raslan

2016

Open Access Maced J Med Sci

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AIM:This study aimed to investigate genotype and allele frequencies of −174 (rs1800795) and −572 (rs1800796) IL-6 promoter gene polymorphisms in Egyptian patients with rheumatoid arthritis (RA) in comparison to control group.METHODS:The study was conducted on 198 Egyptian subjects (99 RA patients and 99 healthy control). The promoter region of the IL-6 gene was amplified by PCR using DNAs from patients and the controls, and their PCR products were digested by suitable enzymes.RESULTS:No statistical differences were found in −572G/C genotype (P = 0.177) or allele (P = 0.147) frequencies between RA patients and controls. Significant differences were observed in −174G/C genotype (P < 0.001) and allele (P < 0.001) frequencies between RA patients and controls.CONCLUSION:A significant association of IL-6 −174G/C gene polymorphism and RA in Egyptian population was found with significantly higher frequencies of GC and CC genotypes and C allele in RA patients compared to controls. No association was found between IL-6 −572G/C gene polymorphism and RA.

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Section: Methodsmentioning

confidence: 99%

Assessment of the âˆ’174G/C (rs1800795) and âˆ’572G/C (rs1800796) Interleukin 6 Gene Polymorphisms in Egyptian Patients with Rheumatoid Arthritis

Amr

El-Awady

Raslan

2016

Open Access Maced J Med Sci

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“…Instead, cancerous cells disrupt tissue homeostasis, disturbing different cell types and contributing to disease progression, through interactions with mediators of the immune system [4–6]. Oral squamous cell carcinoma (OSCC) is a solid tumour of epithelial origin that affects more than 400,000 individuals annually worldwide [7].…”

Section: Introductionmentioning

confidence: 99%

Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge

et al. 2017

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BackgroundOral squamous cell carcinoma (OSCC) accounts over 90% of malignant neoplasms of the oral cavity. This pathological entity is associated to a high mortality rate that has remained unchanged over the past decades. Tumour-associated macrophages (TAMs) are believed to have potential involvement in OSCC progression. However, the molecular networks involved in communication between stroma and cancer cells have not yet been fully elucidated.Main bodyThe role of M2 polarized cells in oral carcinogenesis is supported by a correlation between TAMs accumulation into OSCC stroma and poor clinical outcome. Signalling pathways such as the NF-κB and cytokines released in the tumour microenvironment promote a bidirectional cross-talk between M2 and OSCC cells. These interactions consequently result in an increased proliferation of malignant cells and enhances aggressiveness, thus reducing patients’ survival time.ConclusionsHere, we present a comprehensive review of the role of interleukin (IL)-1, IL-4, IL-6, IL-8, IL-10 and the receptor tyrosine kinase Axl in macrophage polarization to an M2 phenotype and OSCC progression. Understanding the molecular basis of oral carcinogenesis and metastatic spread of OSCC would promote the development of targeted treatment contributing to a more favourable prognosis.

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“…IL-6 is secreted by T cells and macrophages that are capable of inducing immune responses, including responses to trauma (Singh et al, 2015). The IL-6 gene, located on chromosome 7p21-24, has three single nucleotide polymorphisms (SNPs) within its promoter region (Terry et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

Zhu¹,

Li²,

Li³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured using enzyme-linked immunosorbent assay (ELISA). Results indicated that when the IL-6 -572 CC homozygote genotype was used as the reference group, the GG genotype was found to be associated with a significantly increased risk of KS (GG vs CC: OR = 2.097, 95%CI = 1.100-3.995, P = 0.025). When the IL-6 -572 C allele was used as the reference group, the G allele was found to be associated with significantly increased risk of KS (G vs C: OR = 1.317, 95%CI = 1.002-1.730, P = 0.048). Furthermore, we observed a marked 2 X.J. Zhu et al. Genetics and Molecular Research 16 (2): gmr16029110 increase in serum IL-6 levels in KS patients with GG genotypes when compared to KS patients harboring the CC genotype. In conclusion, our results suggest that IL-6 gene polymorphism was associated with keloid scars in the southeastern Chinese Han population.

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Association of interleukin-6 genetic polymorphisms with risk of OSCC in Indian population

Cited by 20 publications

References 45 publications

Assessment of the âˆ’174G/C (rs1800795) and âˆ’572G/C (rs1800796) Interleukin 6 Gene Polymorphisms in Egyptian Patients with Rheumatoid Arthritis

Assessment of the âˆ’174G/C (rs1800795) and âˆ’572G/C (rs1800796) Interleukin 6 Gene Polymorphisms in Egyptian Patients with Rheumatoid Arthritis

Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

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