Association of interpregnancy interval and gestational diabetes mellitus

Chou, Jody S.; Packer, Claire H.; Mittleman, Murray A.; Valent, Amy M.

doi:10.1080/14767058.2022.2134770

Cited by 4 publications

(19 citation statements)

References 20 publications

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“…A large-sample study from the United States suggested that intervals of less than 6, 6-11, and 12-17 months had a signi cant overall protective effect against GDM (aRR: 0.89-0.98) 23 . In a nationwide data analysis from the United States, a short IPI (6-17 months) was also associated with an increased risk of GDM 15 . These studies indicate that the association between a short IPI and GDM remains unclear.…”

Section: Resultsmentioning

confidence: 99%

“…Results concerning the association between a long IPI and GDM also differ between studies. A study from China found that only an extremely long IPI of at least 120 months increased the risk of GDM 17 , whereas data from the United States suggested that an IPI of over 36 months signi cantly increased the risk of GDM 15 . A largesample study from Uruguay found that neither short nor long IPIs had a signi cant effect on the risk of GDM 18 .…”

Section: Introductionmentioning

confidence: 99%

“…However, studies on the association between a short IPI and the risk of GDM are contradictory. Studies from Canada 14 and the United States 15 have suggested that a short IPI increases the risk of GDM in the second pregnancy, whereas research from Australia found that a shorter IPI had a protective effect on the risk of GDM 16 . Results concerning the association between a long IPI and GDM also differ between studies.…”

Section: Introductionmentioning

confidence: 99%

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Effect of interpregnancy interval on the risk of gestational diabetes mellitus during a second pregnancy

Deng

Yang

et al. 2023

Preprint

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Purpose This study aimed to analyze the effect of interpregnancy interval (IPI) on the risk of gestational diabetes mellitus (GDM) in the Chinese population. Methods Female participants who had consecutive singleton deliveries in Peking University Shenzhen Hospital from 2013 to 2021 were selected for this retrospective cohort study. They were divided into GDM and non-GDM groups according to whether GDM was a complication in the second pregnancy. IPI and other possible GDM risk factors in the second pregnancy were assayed by univariate and multivariate logistic regression analysis. Results A total of 2,392 female participants were enrolled. The IPI of the GDM group was significantly greater than that of the non-GDM group (P < 0.05). Compared with the 18–23 months IPI category, participants with longer IPIs (24–35 months, 36–47 months, 48–59 months, and ≥60 months) had a higher risk of GDM (aOR:1.590, 2.390, 2.493, and 2.581; 95% CI: 1.026–2.464, 1.498–3.814, 1.447–4.297, and 1.303–5.109, respectively). The GDM risk was not significantly changed in participants with shorter IPIs (12–17 months, 18–23 months; P﹥0.05). A model consisting of IPI, maternal age, body mass index, and previous GDM manifested the best discrimination for GDM in the second pregnancy [AUC = 0.758 (95% CI: 0.728–0.788), P < 0.001]. For participants aged <35 years or without previous GDM, the risk of GDM significantly increased when the IPI was ≥36 months. The minimum IPI for a significant increase in GDM risk was 24–35 months in the participants with previous GDM. Conclusions An IPI longer than 24 months was associated with an increased GDM risk. The risk of GDM in a second pregnancy for women with previous GDM was more significantly affected by the IPI.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of interpregnancy interval on the risk of gestational diabetes mellitus during a second pregnancy

Deng

Yang

et al. 2023

Preprint

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“…However, studies on the association between a short IPI and the risk of GDM are contradictory. Studies from Canada [ 14 ] and the United States [ 15 ] have suggested that a short IPI increases the risk of GDM in the second pregnancy, whereas research from Australia found that a shorter IPI had a protective effect on the risk of GDM [ 16 ]. Results concerning the association between a long IPI and GDM also differ between studies.…”

Section: Introductionmentioning

confidence: 99%

“…Results concerning the association between a long IPI and GDM also differ between studies. A study from China found that only an extremely long IPI of at least 120 months increased the risk of GDM [ 17 ], whereas data from the United States suggested that an IPI of over 36 months significantly increased the risk of GDM [ 15 ]. A large-sample study from Uruguay found that neither short nor long IPIs had a significant effect on the risk of GDM [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of interpregnancy interval on the risk of gestational diabetes mellitus during a second pregnancy

Deng,

Xu,

Yang

et al. 2024

BMC Pregnancy Childbirth

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Background Interpregnancy interval (IPI) is associated with the risk of GDM in a second pregnancy. However, an optimal IPI is still need to be determined based on the characteristics of the population. This study aimed to analyze the effect of interpregnancy interval (IPI) on the risk of gestational diabetes mellitus (GDM) in the Chinese population. Methods We conducted a retrospective cohort study on female participants who had consecutive deliveries at Peking University Shenzhen Hospital from 2013 to 2021. The IPI was categorized into 7 groups and included into the multivariate logistic regression model with other confound factors. Analysis was also stratified based on age of first pregnancy, BMI, and history of GDM. Adjusted OR values (aOR) and 95% confidence intervals (CI) calculated. The regression coefficient of IPI months on GDM prediction risk was analyzed using a linear regression model. Results A total of 2,392 participants were enrolled. The IPI of the GDM group was significantly greater than that of the non-GDM group (P < 0.05). Compared with the 18–24 months IPI category, participants with longer IPIs (24–36 months, 36–48 months, 48–60 months, and ≥ 60 months) had a higher risk of GDM (aOR:1.585, 2.381, 2.488, and 2.565; 95% CI: 1.021–2.462, 1.489–3.809, 1.441–4.298, and 1.294–5.087, respectively). For participants aged < 30 years or ≥ 30 years or without GDM history, all longer IPIs (≥ 36 months) were all significantly associated with the GDM risk in the second pregnancy (P < 0.05), while any shorter IPIs (< 18 months) was not significantly associated with GDM risk (P > 0.05). For participants with GDM history, IPI 12–18 months, 24–36 months, 36–48 months, and ≥ 60 months were all significantly associated with the GDM risk (aOR: 2.619, 3.747, 4.356, and 5.373; 95% CI: 1.074–6.386, 1.652–8.499, 1.724–11.005, and 1.078–26.793, respectively), and the slope value of linear regression (0.5161) was significantly higher compared to participants without a history of GDM (0.1891) (F = 284.168, P < 0.001). Conclusions Long IPI increases the risk of GDM in a second pregnancy, but this risk is independent of maternal age. The risk of developing GDM in a second pregnancy for women with GDM history is more significantly affected by IPI.

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The association between interpregnancy interval and gestational diabetes mellitus: A nationwide register‐based study in Finland

Vaajala,

Liukkonen,

Tarkiainen

et al. 2024

Intl J Gynecology & Obste

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ObjectivePrevious results on the association between interpregnancy interval (IPI) and gestational diabetes mellitus (GDM) have been contradictory. Hence, the aim of this study was to examine the association between IPI and GDM using high‐quality nationwide register data.MethodsAll women with first and second pregnancies during our study period from the National Medical Birth Register during 2004–2018 were considered. A logistic regression model was used to assess the association between the length of the IPI and development of the GDM in the second pregnancy. Women were divided into three groups based on the length of the IPI: short IPI (0–11 months), normal IPI (12–47 months), and long IPI (48+ months). Adjusted odds ratios (aOR) with 95% CI were compared between the groups.ResultsA total of 47 078 women were included in the study. We found no evidence of difference when women with short IPI were compared with women with normal IPI (aOR 0.99, 95% CI 0.93–1.05). Women with long IPI had increased odds for the development of GDM when compared with women with normal IPI (aOR 1.28, 95% CI 1.19–1.38). In the logistic regression model for continuous IPI, the total odds for the development of GDM increased as the IPI increased (aOR 1.05 per year, 95% CI 1.03–1.06).ConclusionThe odds for the development of GDM increased as the IPI increased. This study's results serve as a clarion call for proactive measures in GDM prevention. Moreover, they advocate for intensified investigation into the underlying factors contributing to GDM among women with extended IPI. It is imperative that these insights inform both clinical practice and further research agendas, as we strive to safeguard maternal health and well‐being.

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Association of interpregnancy interval and gestational diabetes mellitus

Cited by 4 publications

References 20 publications

Effect of interpregnancy interval on the risk of gestational diabetes mellitus during a second pregnancy

Effect of interpregnancy interval on the risk of gestational diabetes mellitus during a second pregnancy

Effect of interpregnancy interval on the risk of gestational diabetes mellitus during a second pregnancy

The association between interpregnancy interval and gestational diabetes mellitus: A nationwide register‐based study in Finland

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