Association of Intraocular Pressure With Human Immunodeficiency Virus

Young, Matthew P.; Melvani, Rakhi; Khan, Farah; Braich, Puneet S.; Bansal, Surbhi

doi:10.1016/j.ajo.2017.01.021

Cited by 2 publications

(6 citation statements)

References 16 publications

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“…Indeed, decreased cone-photoreceptor density in HIV+ participants was found using an adaptive optics camera [59] and SD-OCT visualized possible changes in retinal layers other than GCL and RNFL [5,60,61]. Lower IOP in HIV+ participants was previously described and its causes are more likely multifactorial [61]. Our results showed that this diminished IOP persists in PLHIVs with long-term, well-sustained immune control.…”

Section: Plos Onesupporting

confidence: 65%

“…That decline could however be explained by functional changes without structural damage of the retinal ganglion cells or other cells implicated in vision. Indeed, decreased cone-photoreceptor density in HIV+ participants was found using an adaptive optics camera [59] and SD-OCT visualized possible changes in retinal layers other than GCL and RNFL [5,60,61]. Lower IOP in HIV+ participants was previously described and its causes are more likely multifactorial [61].…”

Section: Plos Onementioning

confidence: 84%

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Absence of peripapillary retinal nerve-fiber–layer thinning in combined antiretroviral therapy-treated, well-sustained aviremic persons living with HIV

et al. 2020

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To compare peripapillary retinal nerve-fiber-layer (pRNFL) thickness, total retina macular volume, and ganglion-cell-layer (GCL) macular volume and thickness between persons living with HIV (PLHIVs) with well-controlled infections and good immune recovery, and sexand age-matched HIV-uninfected controls (HUCs). Methods This prospective cross-sectional study (www.clinicaltrials.gov identifier: NCT02003989) included 56 PLHIVs, infected for �10 [median 20.2] years and with sustained plasma HIVload suppression on combined antiretroviral therapy (cART) for �5 years, and 56 matched HUCs. Participants underwent spectral-domain optical coherence tomography (SD-OCT) with thorough ophthalmological examinations and brain magnetic resonance imaging (MRI). Their overall and quadrant pRNFL thicknesses, total macular volumes, and GCL macular volumes and thicknesses were compared. Cerebral small-vessel diseases (CSVD) complied with STRIVE criteria. Results Median [interquartile range, IQR] ages of PLHIVs and HUCs, respectively, were 52 [46-60] and 52 [44-60] years. Median [IQR] PLHIVs' nadir CD4+ T-cell count and current CD4/CD8 T-cell ratio were 249/μL [158-350] and 0.

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Section: Plos Onesupporting

confidence: 65%

Section: Plos Onementioning

confidence: 84%

Absence of peripapillary retinal nerve-fiber–layer thinning in combined antiretroviral therapy-treated, well-sustained aviremic persons living with HIV

et al. 2020

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“…No relevance to demographic data was reported in any other study reviewed,7,8–13 but it was observed in this study that age was a factor with statistical relevance for IOP decrease. It is also added that in the analysis of patients with HIV without treatment was the group with the lowest mean age.…”

Section: Discussioncontrasting

confidence: 70%

“…Recently, IOP was compared in patients with HIV under treatment and without treatment with the control group. The results were promising in knowing that the IOP of HIV patients was lower than the control, and there was a direct relationship with the amount of TCD4 in the patients, where HIV patients were 7 times more likely to have a decrease of IOP and if the TCD4 count was <700 cells/mm 3 there is 13 times greater chance of having a reduction in IOP 7. This study obtained the same pattern of patient division.…”

Section: Discussionsupporting

confidence: 61%

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<p>Intraocular pressure in patients with human immunodeficiency virus, correlation with TCD4, viral load and demographic characteristics: a case–control study</p>

Cravo

Biancardi

Ronconi

et al. 2019

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Purpose To compare if patients with HIV have lower intraocular pressure than patients without HIV. Methods The association of intraocular pressure corrected by pachymetry and the relationship with viral load (VL) and TCD4 cells was studied. A total of 99 patients with HIV (91 who were on regular treatment and in control of the disease – group 1; and 8 who were without treatment – group 2) and 100 controls were studied. Results Only age was of statistical significance; the group with HIV without control of the disease was the youngest. There was a decrease of −1.54 mmHg in the IOP of group 1 in relation to the controls and −3.63 mmHg in the IOP of group 2 in relation to the controls. Conclusion HIV patients had lower IOP than the control population. However, the relationship between IOP, VL and TCD4 was not found.

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Association of Intraocular Pressure With Human Immunodeficiency Virus

Abstract: Absolute CD4 counts may play a role in IOP fluctuations. This association was found in patients with HIV regardless of whether patients were on HAART.

Cited by 2 publications

References 16 publications

Absence of peripapillary retinal nerve-fiber–layer thinning in combined antiretroviral therapy-treated, well-sustained aviremic persons living with HIV

Absence of peripapillary retinal nerve-fiber–layer thinning in combined antiretroviral therapy-treated, well-sustained aviremic persons living with HIV

<p>Intraocular pressure in patients with human immunodeficiency virus, correlation with TCD4, viral load and demographic characteristics: a case–control study</p>

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