Association of intrinsic capacity with functional ability, sarcopenia and systemic inflammation in pre-frail older adults

Frailty is a complex, age-related clinical condition that involves multiple contributing factors and raises the risk of adverse outcomes in older people. Given global population ageing trends, the growing prevalence and incidence of frailty pose significant challenges to health and social care systems in both high-income and lower-income countries. In this review, we highlight the disproportionate representation of research on frailty screening and management from high-income countries, despite how lower-income countries are projected to have a larger share of older people aged ≥60. However, more frailty research has been emerging from lower-income countries in recent years, paving the way for more context-specific guidelines and studies that validate frailty assessment tools and evaluate frailty interventions in the population. We then present further considerations for contextualising frailty in research and practice in lower-income countries. First, the heterogeneous manifestations of frailty call for research that reflects different geographies, populations, health systems, community settings and policy priorities; this can be driven by supportive collaborative systems between high-income and lower-income countries. Second, the global narrative around frailty and ageing needs re-evaluation, given the negative connotations linked with frailty and the introduction of intrinsic capacity by the World Health Organization as a measure of functional reserves throughout the life course. Finally, the social determinants of health as possible risk factors for frailty in lower-income countries and global majority populations, and potential socioeconomic threats of frailty to national economies warrant proactive frailty screening in these populations.

show abstract

Heterogeneous subtypes of intrinsic capacity in middle-aged and older patients after percutaneous coronary intervention: a latent class analysis

Zhao,

Jiang,

et al. 2024

Preprint

View full text Add to dashboard Cite

We aims to explore the associated factors of intrinsic capacity (IC) levels and subtypes in middle-aged and older patients after percutaneous coronary intervention (PCI). The patient health questionnaire-9 (PHQ-9), the mini-mental state examination (MMSE), the short physical performance battery test (SPPB), and the mini-nutritional assessment short form (MNA-SF) were utilized for assessing IC domains. Both aural and visual were self-reported. The study employed latent class analysis (LCA) to investigate the diverse IC subtypes. Logistic regression analyses were used to identify the impact factors of IC levels as well as IC subtypes. We found that 318 middle-aged and older patients who had undergone PCI completed the assessments. Logistic regression results indicated that age, gender, occupation, comorbidity index (CCI), chronic disease resource utilization, multiple coronary artery lesions, and hs-CRP are implicit factors of IC levels. The findings of LCA suggested that three heterogeneous IC subtypes were identified: 47.8% poor audition-vision group (class 1), 38% high cognition-psychology group (class 2), 14.2% low locomotion-vitality group (class 3). Education, exercise frequency, cardiac function, drinking, NT proBNP, and cTnI could affect the IC subtype classification. In conclusion, the determinants of IC levels in middle-aged and older adults after PCI still require more empirical investigation. For targeted intervention, the examination of IC subtypes may bring benefits.

show abstract

Association of intrinsic capacity with functional ability, sarcopenia and systemic inflammation in pre-frail older adults

Cited by 3 publications

References 50 publications

Gan-Mai-Da-Zao-Tang attenuates age-induced skeletal muscle wasting and improves mitochondrial function in mice

Gan-Mai-Da-Zao-Tang attenuates age-induced skeletal muscle wasting and improves mitochondrial function in mice

Frailty: a global health challenge in need of local action

Heterogeneous subtypes of intrinsic capacity in middle-aged and older patients after percutaneous coronary intervention: a latent class analysis

Contact Info

Product

Resources

About