Association of iron-related biomarkers with severity and mortality in COVID-19 patients

Yadav, Dharamveer; Kumar, Pvsn Kiran; Tomo, Sojit; Sankanagoudar, Shrimanjunath; Charan, Jayakaran; Purohit, Abhishek; Nag, Vijaylakshami; Bhatia, Pradeep; Singh, Kuldeep; Dutt, Naveen; Garg, Mahendra Kumar; Sharma, Praveen; Misra, Sanjeev; Purohit, Purvi

doi:10.1016/j.jtemb.2022.127075

Cited by 23 publications

(21 citation statements)

References 51 publications

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“…In turn, PVSN et al [46] reported significantly decreased levels of Cu and Zn in COVID-19 patients when compared to those in controls, disagreeing with our results, which showed higher levels of Cu in COVID-19 patients than in controls, as well as higher levels of Zn in patients undergoing a severe SARS-CoV-2 infection, than patients with an asymptomatic or mild infection, along with controls. Additionally, our results disagree with Yadav et al [47] , who found a significantly decreased levels of Fe in COVID-19 patients. Although Fe was also determined in serum, the different analytical strategies were applied (direct colorimetric method vs. ICP-MS) might had led to different results.…”

Section: Resultscontrasting

confidence: 99%

The concentrations of essential/toxic elements in serum of COVID-19 patients are not directly related to the severity of the disease

Marquès

Iftimie

Camps

et al. 2023

Journal of Trace Elements in Medicine and Biology

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Section: Resultscontrasting

confidence: 99%

The concentrations of essential/toxic elements in serum of COVID-19 patients are not directly related to the severity of the disease

Marquès

Iftimie

Camps

et al. 2023

Journal of Trace Elements in Medicine and Biology

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“…It is shown that transferrin is a good marker for COVID-19 severity (18,47,48). A study by Yadav et al (47) showed a trend for lower transferrin concentration with increasing disease severity, as shown in our study.…”

Section: Discussionsupporting

confidence: 86%

The utility of serum amyloid A and other acute-phase reactants determination in ambulatory care COVID-19 patients

Jegorovic¹,

Nikolić

Milinković

et al. 2023

J Med Biochemistry

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Background: The unpredictable course of Coronavirus Disease 19 (COVID-19) is making good severity assessment tools crucial. This study aimed to assess the usefulness of serum amyloid A (SAA) and other acute-phase reactants (APRs) in ambulatory COVID-19 patients and identified relationships between these markers and disease outcomes. Methods: From August to November 2020, patients seen in the outpatient department of the Clinic for Infectious and Tropical Diseases (Belgrade, Serbia) with confirmed COVID-19 were included. Based on World Health Organization criteria, patients were classified into mild, moderate, and severe disease groups. SAA, C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT), ferritin, fibrinogen, D-dimer, albumin, and transferrin were measured. The Receiver operator characteristic (ROC) curve analysis was used for the classification characteristics assessment of individual APRs for the severity of illness, hospitalization, and survival. The median values of all APRs were compared between COVID-19 severity groups, hospitalized and non-hospitalized patients, and survivors and non-survivors. Results: Higher levels of SAA, CRP, IL-6, PCT, and lower levels of transferrin and albumin were observed in severe cases, hospitalized patients, and non-survivors. Based on ROC curve analysis AUC for SAA has fair classification performance for disease severity (0.794) and death (0.732) and good performance for hospitalization (0.853). Conclusion: SAA is a valuable marker in everyday practice for assessing COVID-19 severity and prognosis in ambulatory patients.

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“…The study results differ from Moreira et al who found that serum levels of iron and transferrin levels at admission were lower in COVID-19-positive than in COVID-19-negative patients. Moreover, another study by Yadav et al reported significantly decreased levels of iron, transferrin, and TIBC, and significantly increased levels of transferrin and ferritin saturation in COVID-19 cases compared to controls [11,12].…”

Section: Discussionmentioning

confidence: 92%

The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients.

Atef

Ramadan

Abdel-Haleem

et al. 2023

Microbes and Infectious Diseases

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Background and rationale: Coronavirus disease 2019 (COVID-19) infection is a respiratory tract infection because of a novel coronavirus. The clinical picture ranges from asymptomatic to severe manifestations mandating intensive care and respiratory support. We aimed to assess the serum level of iron, total iron binding capacity (TIBC), and transferrin saturation in COVID-19 patients and their relation to disease severity and outcome. Methodology: This observational cross-sectional analytical study was conducted on 100 confirmed cases of COVID-19 who were admitted to Kasr Al-Ainy hospitals between June and December 2020.Serum levels of iron, total iron binding capacity (TIBC), and transferrin saturation were measured for all study populations. Result: One hundred patients were involved in this research, 51males and 49 females, with a mean age of 51±14.9years. Regarding the disease severity,53% were moderate cases, 34% were mild, and 13% were severe cases. Fifty-two (54.2%) patients showed normal serum levels of iron, 38 patients (39.6%) showed high serum levels of iron, and 6 patients (6.3%) showed low serum levels of iron. The mean ±SD values of iron, TIBC, and transferrin saturation were 163.1±105 mcg/dL, 366 ± 162.6 mcg/dL, 44.4 ± 20.2 %, respectively. Iron, total iron binding capacity (TIBC) levels and transferrin saturation did not show a significant association as regards either COVID-19 severity or mortality. Mortality and deterioration were detected in 31.7% out of 60 patients with COVID-19. The results showed that obese patients showed a higher percentage of severe COVID-19,which was statistically significant (p=0.037).There was a statistically significant higher mortality rate in patients with severe COVID-19 (p=0.000).High mortality was observed significantly in patients with diabetes mellitus (p=0.041).Iron levels, total iron binding capacity (TIBC) levels and transferrin saturation did not show a significant association regarding either COVID-19 severity or mortality. Conclusion: In our study, COVID-19 severity was not related to iron metabolism but was affected by obesity and diabetes mellitus. COVID-19 mortality was significantly associated with diabetes.

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Association of iron-related biomarkers with severity and mortality in COVID-19 patients

Cited by 23 publications

References 51 publications

The concentrations of essential/toxic elements in serum of COVID-19 patients are not directly related to the severity of the disease

The concentrations of essential/toxic elements in serum of COVID-19 patients are not directly related to the severity of the disease

The utility of serum amyloid A and other acute-phase reactants determination in ambulatory care COVID-19 patients

The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients.

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