Association of Janus kinase 2 polymorphisms with growth and reproduction traits in chickens

Liu, W. J.; Sun, Dan; Yu, Ying; Li, G.; Tang, Shaoqing; Zhang, Y.; Wang, Y. C.

doi:10.3382/ps.2010-00988

Cited by 19 publications

(10 citation statements)

References 26 publications

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“…The complex It has been proposed that Aβ can cause signaling amplification that inactivates superoxide dismutase (SOD-2) and generates additional free radicals 56 . Moreover, AD model mice crossed with SOD-2 heterozygous knock out mice exhibited increased plaque deposition and tau phosphorylation in their brain 57 . Administration SOD reduces hippocampal superoxide and prevents memory deficits in a mouse model of AD 58,59 .…”

Section: Esi-msmentioning

confidence: 99%

Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer’s Disease

et al. 2014

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Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work of researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-forprofit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. Publisher's statement:This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/ja502789eThe version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP url' above for details on accessing the published version and note that access may require a subscription. ABSTRACT: Stereochemistry is a very important issue for pharmaceutical industry and can determine drug efficacy. Design and synthesis of small molecules, especially chiral molecules, which selectively target and inhibit amyloid (Aβ) aggregation represent valid therapeutic strategies for treatment of Alzheimer's disease (AD). Herein we report that two triple-helical dinuclear metallo-supramolecular complexes can act as a novel class of chiral amyloid-β inhibitors. Through targeting α/β-discordant stretches at the early steps of aggregation, these metal complexes can enantioselectively inhibit Aβ aggregation, which are demonstrated using fluorescent living cell-based screening and multiple biophysical and biochemical approaches. To the best of our knowledge, there is no report to show that a chiral compound can enantioselectively inhibit Aβ aggregation. Intriguingly, as a promising candidate for AD treatment, the chiral metal complex can cross the blood-brain barrier (BBB) and have SOD activity. Previous studies have demonstrated that chiral discrimination between enantiomers is extremely important, as stereopure drugs can often reduce the total dose of drug given and minimize any toxicity resulting from the inactive enantiomer. And this is also a critical factor which should be carefully considered in AD treatment. Our work provides new insights into chiral inhibition of Aβ aggregation and opens a new avenue for design and screening of chiral agents as Aβ inhibitors against AD.

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Section: Esi-msmentioning

confidence: 99%

Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer’s Disease

et al. 2014

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“…This approach enables more efficient breeding selection for egg production traits in chickens. Therefore, identification and application of potential candidate genes and associated genotypes can have significant economic implications and have become increasingly important in poultry breeding programs [27, 44, 48]. However, more candidate genes and single nucleotide polymorphisms (SNPs) are required for MAS in chicken breeding.…”

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confidence: 99%

Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens

Niu

Tyasi

Qin

et al. 2017

The Journal of Veterinary Medical Science

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Estrogen receptors α (ESR1) and β (ESR2) play central roles in folliculogenesis and therefore in reproductive biology. In the present study, two single nucleotide polymorphisms (SNPs) were identified in the ESR1 and ESR2 genes using PCR-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing. One of the identified SNPs, a T1101C transition located within exon 4 of the ESR1 gene, was significantly associated with hen-housed egg production (HHEP) at 30, 43, 57 and 66 weeks of age (P<0.05), and egg weight (EW) at 30 weeks (P<0.05). Another SNP, a G1755A transition leading to a non-synonymous substitution (valine 459-to-isoleucine) located within exon 8 of the ESR2 gene, was also markedly correlated with the HHEP at 30, 43, 57 and 66 weeks of age (P<0.05), and EW at 30 weeks (P<0.05). A greater proportion of the additive variance was explained by the SNPs for most of the associated egg production traits (>1%). Furthermore, the results of the combined genotype-based association analysis supported the finding that the two SNPs were associated with the traits under a study. Taken together, our findings suggest that the two sequence variations in the ESR1 and ESR2 genes may provide promising genetic markers for the early selection and prediction of advantageous phenotypes in chicken breeding.

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“…GNAI1 is connected with many signalling pathways. The influence of JAK2 gene on growth and reproduction trait was confirmed in meat-type chicken (Liu et al, 2010). The expression of SEMA3A was observed in central nervous system, typically in gray matter of spinal cord in chicken embryos (Fu et al 2000).…”

Section: Resultsmentioning

confidence: 96%

The search for SNPs and genes associated with the feed conversion ratio using entropy analysis

Graczyk

Reyer

Wimmers

et al. 2016

Acta fytotechn zootechn

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The aim of this study was to detect the chromosomal regions connected with feed conversion ratio and point out the respective genes in meat-type chicken. Analysis covered 862 genotyped commercial line of broiler using 60K Illumina iSelect chicken array and obtained information about 57636 SNPs. Feed conversion ratio between 39-46 days were registered. Finally, 42770 SNPs were analysed. The information theory is employed to detect the association between SNPs and recorded traits. The following parameters were estimated: entropy coefficient, conditional entropy, portion of information and mutual information. Important regions at chromosomes 1 and Z were identified. They are mainly located within genes determining the nervous system and expressed also in gastrointestinal tract.

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Association of Janus kinase 2 polymorphisms with growth and reproduction traits in chickens

Cited by 19 publications

References 26 publications

Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer’s Disease

Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer’s Disease

Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens

The search for SNPs and genes associated with the feed conversion ratio using entropy analysis

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