Association of KCNQ1 Polymorphism with Type 2 Diabetes in Mexican Population

Abstract

Introduction: The KCNQ1 gene has been known to play a role in insulin secretion and has shown association with Type 2 diabetes mellitus (T2D). The aim of the study was to investigate the association of the KCNQ1 polymorphisms rs2237892 and rs2237895 with T2D and related clinical quantitative traits. Methods:We genotyped two single nucleotide polymorphisms (SNPs) in KCNQ1 gene, rs2237892 and rs2237895, in 230 patients with T2D and 234 controls that had no other metabolic traits in a sample obtained from Mexican population. Genotypic and allelic frequencies were evaluated, and logistic regression was used to evaluate the association between the SNPs and T2D risk. Results:The KCNQ1 polymorphism rs2237892 was associated with T2D (odds ratio, OR: 1.58 (95% CI (1.200-2.074, P= 0.001). Also, polymorphism rs2237892 was associated with LDL-C levels (P = 0.044) in T2D patients in comparison to the control group. No significant difference in genotypic frequencies of rs2237895 was observed between T2D patients and controls. Conclusion:This study confirms that the KCNQ1 polymorphism rs2237892 is associated with type 2 diabetes and that it influences LDL-C levels in the Mexican population.