Association of Ki-67 Labelling Index and IL-17A with Pituitary Adenoma

Glebauskiene, Brigita; Liutkevičienė, Rasa; Vilkeviciute, Alvita; Gudinavičienė, Inga; Rocyte, Aurelija; Simonaviciute, Dovile; Mazetytė, Rūta; Kriauciuniene, Loresa; Žaliūnienė, Dalia

doi:10.1155/2018/7490585

Cited by 17 publications

(12 citation statements)

References 40 publications

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“…Obviously, correct assessment of tumor invasion is mandatory for this approach, as is evaluation of proliferation. Indeed, in our review of the literature we found a robust association between proliferation, assayed by Ki-67, and presence of invasiveness with 62% of revised reports suggesting a positive correlation [145][146][147] and 38% indicating an unclear association, albeit with a positive trend [13,148,149]. The controversial data on p53 and Ki-67 expression and correlation with invasiveness might in part be a result of differences in defining invasion, as reported by Sarkar et al [140] and discussed herein.…”

Section: Pathological and Molecular Considerationsmentioning

confidence: 99%

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Serioli

Doglietto

Fiorindi

et al. 2019

Cancers

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Invasiveness in pituitary adenomas has been defined and investigated from multiple perspectives, with varying results when its predictive value is considered. A systematic literature review, following PRISMA guidelines, was performed, searching PubMed and Scopus databases with terms that included molecular markers, histological, radiological, anatomical and surgical data on invasiveness of pituitary adenomas. The results showed that differing views are still present for anatomical aspects of the sellar region that are relevant to the concept of invasiveness; radiological and histological diagnoses are still limited, but might improve in the future, especially if they are related to surgical findings, which have become more accurate thanks to the introduction of the endoscope. The aim is to achieve a correct distinction between truly invasive pituitary adenomas from those that, in contrast, present with extension in the parasellar area through natural pathways. At present, diagnosis of invasiveness should be based on a comprehensive analysis of radiological, intra-operative and histological findings.

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Section: Pathological and Molecular Considerationsmentioning

confidence: 99%

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Serioli

Doglietto

Fiorindi

et al. 2019

Cancers

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“…The invasiveness of adenomas and other tumors is also evaluated in terms of pathological parameters, such as mitotic figures, Ki-67 index ( 35 , 36 ) and p53 expression in the malignant tissues ( 26 ). Petry et al.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Related Factors of Tumor Recurrence or Progression After Transnasal Sphenoidal Surgical Treatment of Large and Giant Pituitary Adenomas and Establish a Nomogram to Predict Tumor Prognosis

et al. 2021

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BackgroundPituitary adenoma (PA) is a benign neuroendocrine tumor caused by adenohypophysial cells, and accounts for 10%-20% of all primary intracranial tumors. The surgical outcomes and prognosis of giant pituitary adenomas measuring ≥3 cm in diameter differ significantly due to the influence of multiple factors such as tumor morphology, invasion site, pathological characteristics and so on. The aim of this study was to explore the risk factors related to the recurrence or progression of giant and large PAs after transnasal sphenoidal surgery, and develop a predictive model for tumor prognosis.MethodsThe clinical and follow-up data of 172 patients with large or giant PA who underwent sphenoidal surgery at the Second Affiliated Hospital of Zhejiang University School of Medicine from January 2011 to December 2017 were retrospectively analyzed. The basic clinical information (age, gender, past medical history etc.), imaging features (tumor size, invasion characteristics, extent of resection etc.), and histopathological characteristics (pathological results, Ki-67, P53 etc.) were retrieved. SPSS 21.0 software was used for statistical analysis, and the R software was used to establish the predictive nomogram.ResultsSeventy out of the 172 examined cases (40.7%) had tumor recurrence or progression. The overall progress free survival (PFS) rates of the patients at 1, 3 and 5 years after surgery were 90.70%, 79.65% and 59.30% respectively. Log-rank test indicated that BMI (P < 0.001), Knosp classification (P < 0.001), extent of resection (P < 0.001), Ki-67 (P < 0.001), sphenoidal sinus invasion (P = 0.001), Hardy classification (P = 0.003) and smoking history (P = 0.018) were significantly associated with post-surgery recurrence or progression. Cox regression analysis further indicated that smoking history, BMI ≥25 kg/m2, Knosp classification grade 4, partial resection and ≥3% Ki-67 positive rate were independent risk factors of tumor recurrence or progression (P < 0.05). In addition, the nomogram and ROC curve based on the above results indicated significant clinical value.ConclusionThe postoperative recurrence or progression of large and giant PAs is related to multiple factors and a prognostic nomogram based on BMI (≥25 kg/m2), Knosp classification (grade 4), extent of resection (partial resection) and Ki-67 (≥3%) can predict the recurrence or progression of large and giant PAs after transnasal sphenoidal surgery.

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“…The patients included 34 males and 39 females, with a median age of 55 years (range 25–73 years) and a median follow-up of 78 months (range 36–121 months). Tumors with Hardy-Wilson classification grade IV and/or Knosp classification grades III and IV ( 32 , 33 ) were defined as invasive. Table I includes the clinical and pathological features of the adenomas.…”

Section: Methodsmentioning

confidence: 99%

A two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma

et al. 2018

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Clinical non-functioning pituitary adenoma (NFPA) accounts for >30% of all pituitary adenomas, and the recurrence rate is notably high. The ability to predict tumour recurrence during initial surgery will aid in determining if adjunctive therapy is required to reduce recurrence. With the aim of developing a circular RNA (circRNA) signature to improve prognosis prediction in NFPA, the present study examined the circRNA expression profiles in 73 patients with NFPA from Beijing Tiantan Hospital using high-throughput RNA chip technology. The dataset was randomly separated into a training group and a test group using an R program. In the training group (n=37), a Cox proportional hazards regression model was used to analyse the genes associated with the recurrence and progression-free survival (PFS) of patients with NFPA. Meanwhile, a random survival forest algorithm, Kaplan-Meier and receiver operating characteristic curve (ROC) analyses were used to determine the multi-circRNA signature with the largest area under the ROC curve (AUROC) and verify its efficacy in the test group (n=36). In the training and test groups, the signatures of two circRNAs (hsa_circ_0000066 and hsa_circ_0069707) were specifically associated with the PFS of patients with NFPA (log-rank P<0.05). Furthermore, the two-circRNA signature had a high prediction accuracy for tumour recurrence, with an AUROC of 0.87 and 0.67 in the training and test groups, respectively; and the discriminative power of the signature was greater compared with that of age. The present study is the first to suggest a circRNA signature with a clinical application value for predicting recurrence/progression in patients with NFPA.

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Association of Ki-67 Labelling Index and IL-17A with Pituitary Adenoma

Cited by 17 publications

References 40 publications

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Analysis of Related Factors of Tumor Recurrence or Progression After Transnasal Sphenoidal Surgical Treatment of Large and Giant Pituitary Adenomas and Establish a Nomogram to Predict Tumor Prognosis

A two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma

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